ChemicalBook > CAS DataBase List > 3-broMo-5-iodo-phenol

3-broMo-5-iodo-phenol

Product Name
3-broMo-5-iodo-phenol
CAS No.
570391-20-7
Chemical Name
3-broMo-5-iodo-phenol
Synonyms
3-broMo-5-iodo-phenol;Phenol, 3-bromo-5-iodo-
CBNumber
CB52721430
Molecular Formula
C6H4BrIO
Formula Weight
298.9
MOL File
570391-20-7.mol
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3-broMo-5-iodo-phenol Property

Melting point:
82.5 °C
Boiling point:
324.2±32.0 °C(Predicted)
Density 
2.369±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
8.15±0.10(Predicted)
form 
crystalline needles
color 
Light golden brown
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Safety

HS Code 
2908190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B683900
Product name
3-Bromo-5-iodophenol
Packaging
100mg
Price
$165
Updated
2021/12/16
Apolloscientific
Product number
OR46047
Product name
3-Bromo-5-iodophenol
Packaging
1g
Price
$167
Updated
2021/12/16
SynQuest Laboratories
Product number
2601-S-05
Product name
3-Bromo-5-iodophenol
Packaging
1g
Price
$184
Updated
2021/12/16
AK Scientific
Product number
Y1511
Product name
3-Bromo-5-iodo-phenol
Packaging
1g
Price
$264
Updated
2021/12/16
Apolloscientific
Product number
OR46047
Product name
3-Bromo-5-iodophenol
Packaging
250mg
Price
$60
Updated
2021/12/16
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3-broMo-5-iodo-phenol Chemical Properties,Usage,Production

Uses

3-Bromo-5-iodophenol is a reactant in the preparation of N-[3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl]methanesulfonamide (LP-261), a potent antimitotic agent.

Synthesis

915412-18-9

570391-20-7

General procedure for the synthesis of 3-bromo-5-iodophenol from 1-bromo-3-iodo-5-methoxybenzene: 1-bromo-3-iodo-5-methoxybenzene (6.29 g, 20.1 mmol) was suspended in a 33% hydrogen bromide solution in acetic acid (150 mL). Tetrabutylammonium bromide (0.5 g, 1.55 mmol) was added and the mixture was heated to reflux with vigorous stirring and the reaction continued for 2 days. After completion of the reaction, the mixture was cooled to room temperature and extracted with dichloromethane (3 × 100 mL). The organic layers were combined, washed with water (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel (300 g of silica gel, eluent ethyl acetate/heptane 1:9) to afford 3-bromo-5-iodophenol (21.2 g, 96% yield) as a light brown solid.

References

[1] Patent: US2006/270686, 2006, A1. Location in patent: Page/Page column 41
[2] Patent: US2008/280891, 2008, A1. Location in patent: Page/Page column 41
[3] Patent: WO2008/8059, 2008, A1. Location in patent: Page/Page column 117

3-broMo-5-iodo-phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-broMo-5-iodo-phenol Suppliers

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570391-20-7, 3-broMo-5-iodo-phenolRelated Search:

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  • 3-broMo-5-iodo-phenol
  • Phenol, 3-bromo-5-iodo-
  • 570391-20-7