ChemicalBook > CAS DataBase List > Bevirimat
Bevirimat
- Product Name
- Bevirimat
- CAS No.
- 174022-42-5
- Chemical Name
- Bevirimat
- Synonyms
- BVM;PA-457;CS-1322;FH 11327;MPC-4326;Bevirimat;Bevirimat, >99%;Bevirimat(PA-457);BVM; MPC-4326; PA-457;Bevirimat 174022-42-5
- CBNumber
- CB22498801
- Molecular Formula
- C36H56O6
- Formula Weight
- 584.83
- MOL File
- 174022-42-5.mol
More
Less
Bevirimat Property
- Melting point:
- >263°C (dec.)
- Boiling point:
- 662.7±40.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Acetonitrile (Slightly), Methanol (Very Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 4.48±0.28(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21339
- Product name
- PA-457
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21339
- Product name
- PA-457
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $254
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21339
- Product name
- PA-457
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21339
- Product name
- PA-457
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1115
- Updated
- 2024/03/01
TRC
- Product number
- B334700
- Product name
- Bevirimat
- Packaging
- 2.5mg
- Price
- $150
- Updated
- 2021/12/16
More
Less
Bevirimat Chemical Properties,Usage,Production
Description
PA-457 is an inhibitor of HIV-1 virion maturation. It inhibits the cleavage of the Gag capsid (CA) precursor CA-SP1 to the mature CA protein. PA-457 inhibits the replication of drug-sensitive and -resistant clinical isolates of HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs; mean IC50s = 10.3 and 7.8 nM, respectively). In vivo, it prevents replication of HIV-1 in SCID-hu Thy/Liv mice when administered at a dose of 100 mg/kg.
Uses
Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.
Definition
ChEBI: A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhib tors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.
Enzyme inhibitor
This first-in-class, natural product-based antiviral (FW = 584.83 g/mol; CAS 174022-42-5; Abbreviation: BVM), also known as 3-O-(3',3'- dimethylsuccinyl)betulinate (DSB), 3β-(3-carboxy-3-methyl-butanoyloxy)- lup-20(29)-en-28-oic acid, PA-457, and MPC-4326, is a novel HIV-1 maturation inhibitor that blocks proteolytic processing of the Gag capsid precursor (CA-SP1) into mature capsid (CA) protein. Bevirimat binds to the Gag polypeptide at the CA/SP1 cleavage site. The net result of BVM treatment is the release of immature, noninfectious viral particles. Despite its promising mode of action, about half of all patients have viruses containing genetic polymorphisms in the Gag SP1 (at positions 6 to 8) protein do not respond to BVM treatment.
target
HIV
Bevirimat Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Bevirimat Suppliers
- Tel
- 182-24028459 18224018291
- 3004072879@qq.com
- Country
- China
- ProdList
- 1223
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 0086-21-67651709
- Fax
- 0086-21-67651705
- cfx759@hotmail.com
- Country
- China
- ProdList
- 410
- Advantage
- 57
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
- Country
- China
- ProdList
- 282
- Advantage
- 59
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9958
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4574
- Advantage
- 55
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 6905
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27313
- Advantage
- 60
- Tel
- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
- ProdList
- 5010
- Advantage
- 55
- Tel
- 021-61847300 13341622919
- Fax
- 021-61847300
- shcss01@163.com
- Country
- China
- ProdList
- 4808
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 17721395025
- Fax
- 021-68882955
- 2423903095@qq.com
- Country
- China
- ProdList
- 4106
- Advantage
- 58
- Tel
- 021-36031160 13311776681
- 3338195766@QQ.com
- Country
- China
- ProdList
- 5175
- Advantage
- 55
- Tel
- 021-69955236-807 13918189704
- Fax
- 021-65211385
- chinaruji@chinaruji.com
- Country
- China
- ProdList
- 5176
- Advantage
- 55
- Tel
- 13438890071
- Fax
- 028-67271232
- 3003796343@qq.com
- Country
- China
- ProdList
- 572
- Advantage
- 58
- Tel
- 028-88203606; 18283602253
- jancyzheng@gcgreenpure.com
- Country
- China
- ProdList
- 1594
- Advantage
- 58
- Tel
- 86-21-50801717-301
- Fax
- 86-21-50800509
- wangjh@sirc-tcm.sh.cn
- Country
- China
- ProdList
- 2070
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52693
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 15805159960
- 1211550495@qq.com
- Country
- China
- ProdList
- 1795
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- +86 13288715578 +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12830
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 18031361688;
- admin@sjztongyang.com
- Country
- China
- ProdList
- 977
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- +86-27-8439 4403 18971486879
- Fax
- +86-27-8439 4403
- sales@chemnorm.com
- Country
- CHINA
- ProdList
- 2935
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
- Tel
- +8615531157085
- Fax
- whatapp+8619930503282
- abby@weibangbio.com
- Country
- China
- ProdList
- 8806
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3600
- Advantage
- 58
- Tel
- 028-81700200 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5173
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29810
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4195
- Advantage
- 58
- Tel
- 19150123681
- Fax
- QQ:3008022628
- Hu.xinyue@purechemland.com
- Country
- China
- ProdList
- 3566
- Advantage
- 58
- Tel
- 021-52961053 13524666654
- 3004902811@qq.com
- Country
- China
- ProdList
- 9724
- Advantage
- 58
- Tel
- 021-57810052 18930344717
- Fax
- 021-57810052
- 2089316240@qq.com
- Country
- China
- ProdList
- 9395
- Advantage
- 58
- Tel
- 021-18721550-091 18721550091
- Fax
- 微信18721550091
- yangdong@pharma.com
- Country
- China
- ProdList
- 4121
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
More
Less
View Lastest Price from Bevirimat manufacturers
Hebei Weibang Biotechnology Co., Ltd
- Product
- Bevirimat 174022-42-5
- Price
- US $8.89/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
Hebei Mujin Biotechnology Co.,Ltd
- Product
- Bevirimat 174022-42-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-05
NanJing Spring & Autumn Biological Engineering CO., LTD.
- Product
- Bevirimat 174022-42-5 174022-42-5
- Price
- US $62.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-09
174022-42-5, BevirimatRelated Search:
roburic acid
Carboxyatractyloside
ALLEOSIDE A
dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
Madecassic acid
Terrestrosin K
Terrestrosin D
Pachymic acid
Poricoic acid A(F)
Madecassoside