ChemicalBook > CAS DataBase List > Bevirimat

Bevirimat

Product Name: Bevirimat
CAS No.: 174022-42-5
Chemical Name: Bevirimat
Synonyms: BVM;PA-457;CS-1322;FH 11327;MPC-4326;Bevirimat;Bevirimat, >99%;Bevirimat(PA-457);BVM; MPC-4326; PA-457;Bevirimat 174022-42-5
CBNumber: CB22498801
Molecular Formula: C36H56O6
Formula Weight: 584.83
MOL File: 174022-42-5.mol

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Bevirimat Property

Melting point:: >263°C (dec.)
Boiling point:: 662.7±40.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Acetonitrile (Slightly), Methanol (Very Slightly, Heated, Sonicated)
form: Solid
pka: 4.48±0.28(Predicted)
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2057
Product name: Bevirimat
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $135
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2057
Product name: Bevirimat
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $545
Updated: 2025/07/31

Cayman Chemical

Product number: 21339
Product name: PA-457
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 21339
Product name: PA-457
Purity: ≥98%
Packaging: 5mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 21339
Product name: PA-457
Purity: ≥98%
Packaging: 10mg
Price: $477
Updated: 2024/03/01

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Bevirimat Chemical Properties,Usage,Production

Description

PA-457 is an inhibitor of HIV-1 virion maturation. It inhibits the cleavage of the Gag capsid (CA) precursor CA-SP1 to the mature CA protein. PA-457 inhibits the replication of drug-sensitive and -resistant clinical isolates of HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs; mean IC₅₀s = 10.3 and 7.8 nM, respectively). In vivo, it prevents replication of HIV-1 in SCID-hu Thy/Liv mice when administered at a dose of 100 mg/kg.

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.

Definition

ChEBI: A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhib tors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.

Enzyme inhibitor

This first-in-class, natural product-based antiviral (FW = 584.83 g/mol; CAS 174022-42-5; Abbreviation: BVM), also known as 3-O-(3',3'- dimethylsuccinyl)betulinate (DSB), 3β-(3-carboxy-3-methyl-butanoyloxy)- lup-20(29)-en-28-oic acid, PA-457, and MPC-4326, is a novel HIV-1 maturation inhibitor that blocks proteolytic processing of the Gag capsid precursor (CA-SP1) into mature capsid (CA) protein. Bevirimat binds to the Gag polypeptide at the CA/SP1 cleavage site. The net result of BVM treatment is the release of immature, noninfectious viral particles. Despite its promising mode of action, about half of all patients have viruses containing genetic polymorphisms in the Gag SP1 (at positions 6 to 8) protein do not respond to BVM treatment.

target

HIV

References

[1] DAVID E MARTIN Graham P A Karl Salzwedel. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection.[J]. Antiviral Chemistry and Chemotherapy, 2008, 19 3: 107-113. DOI: 10.1177/095632020801900301
[2] DAN WANG Feng L Wuxun Lu. Pharmacological intervention of HIV-1 maturation[J]. Acta Pharmaceutica Sinica. B, 2015, 5 6: Pages 493-499. DOI: 10.1016/j.apsb.2015.05.004
[3] F LI. PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 23: 13555-13560. DOI: 10.1073/pnas.2234683100
[4] CHERYL A STODDART. Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.[J]. PLoS ONE, 2007: e1251. DOI: 10.1371/journal.pone.0001251

Bevirimat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bevirimat manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Bevirimat 174022-42-5
Price: US $8.89/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Bevirimat 174022-42-5 174022-42-5
Price: US $62.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

Career Henan Chemical Co

Product: Bevirimat 174022-42-5
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

174022-42-5, BevirimatRelated Search:

roburic acid Carboxyatractyloside ALLEOSIDE A dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate Madecassic acid Terrestrosin K Terrestrosin D Pachymic acid Poricoic acid A(F) Madecassoside

Bevirimat 174022-42-5

Bevirimat, PA 457, FH 312

CS-1322

MPC-4326

PA-457; MPC-4326; FH11327; YK FH312

Bevirimat, >99%

BVM

BVM; MPC-4326; PA-457

Bevirimat

PA-457

FH 11327

O-(3,3-Dimethylsuccinyl)betulinic acid

Bevirimat(PA-457)

Lup-20(29)-en-28-oic acid, 3-(3-carboxy-3-methyl-1-oxobutoxy)-, (3β)-

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-((3-Carboxy-3-methylbutanoyl)oxy)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid

Bevirimat, 10 mM in DMSO

174022-42-5