Drug for the treatment of schizophrenia
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lurasidone

Drug for the treatment of schizophrenia
Product Name
lurasidone
CAS No.
367514-87-2
Chemical Name
lurasidone
Synonyms
CS-327;urasidone;lurasidone;Lurasindone;Lurasidone Base;Lurasidone, >=98%;Lurasidone (SM13496);Lurasidone Free base;lurasidone USP/EP/BP;TIANFU-CHEM - lurasidone
CBNumber
CB22498821
Molecular Formula
C28H36N4O2S
Formula Weight
492.68
MOL File
367514-87-2.mol
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lurasidone Property

Melting point:
146-149°C
Boiling point:
623.4±55.0 °C(Predicted)
Density 
1.273
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka
8.41±0.50(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
InChIKey
PQXKDMSYBGKCJA-CVTJIBDQSA-N
SMILES
C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
CAS DataBase Reference
367514-87-2
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Safety

Hazardous Substances Data
367514-87-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9000570
Product name
Lurasidone
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
9000570
Product name
Lurasidone
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
9000570
Product name
Lurasidone
Purity
≥98%
Packaging
10mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
9000570
Product name
Lurasidone
Purity
≥98%
Packaging
25mg
Price
$412
Updated
2024/03/01
TRC
Product number
L474958
Product name
Lurasidone
Packaging
100mg
Price
$50
Updated
2021/12/16
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lurasidone Chemical Properties,Usage,Production

Drug for the treatment of schizophrenia

Lurasidone is developed by Japan's Dainippon Sumitomo Pharma which is an atypical antipsychotic,and is a classification of drug registration 3.1 class, it is suitable for the treatment of patients with schizophrenia. Its efficacy is Determined in four six weeks in adult patients with schizophrenia controlled studies. The exact mechanism of the treatment of schizophrenia, like other atypical antipsychotics ,is not very clear,and may be related to the antagonism of the dopamine D2 and serotonin 2A (5-HT2A) receptors. For the treatment of schizophrenia, a study has reported lurasidone can improve cognitive function.
October 28, 2010 ,the FDA approved lurasidone hydrochloride (lurasidone HCI) tablets once a day for the first-line treatment of patients with schizophrenia, the trade name is Latuda.
Dosage: The recommended starting dose is 40 mg/d, the effective dose range is 40~120 mg /· d, the maximum recommended dose is 80 mg /· d. It should be taken with food.
Adverse reaction: common adverse reactions are somnolence, akathisia, nausea, Parkinson's disease-like symptoms and emotional anxiety. Lurasidone has no physical dependence, less likely to cause weight gain, it does not cause glucose, lipids (lipids), it changs the period between ECG and QT.
The above information is edited by the Chemicalbook of Tian Ye.

Description

The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.

Originator

Dainippon Sumitomo Pharma (Japan)

Definition

ChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph enia.

brand name

Latuda

lurasidone Preparation Products And Raw materials

Raw materials

Preparation Products

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lurasidone Suppliers

China 202 China Hong Kong 1 Europe 1 India 12 Japan 1 United States 11 Global 228
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
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United States
ProdList
2123
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70
AdooQ BioScience, LLC
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+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
ProdList
2782
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58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
Youth (Shanghai) Chemical Technology Co., Ltd.
Tel
--
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Email
sales_youthchem@163.com
Country
United States
ProdList
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0
Cayman Chemical Company
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--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
MedChemExpress
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sales@medchemexpress.com
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United States
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6398
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Fragmenta
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View Lastest Price from lurasidone manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Lurasidone 367514-87-2
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
500
Release date
2024-05-16
Jinan Million Pharmaceutical Co., Ltd
Product
lurasidone 367514-87-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200KG/M
Release date
2023-08-15
Dideu Industries Group Limited
Product
lurasidone 367514-87-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-23

367514-87-2, lurasidoneRelated Search:

ILOPERIDONE dihydro-o-xylene 3-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1,2-benzothiazole (3aR,4S,7R,7aS)-2-{(1R,2S)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylMethyl]cyclohexylMethyl}hexahydro-4,7-Methano-2H-isoindole-1,3-dione hydrochloride (3aR,4S,7R,7aS)-2-[[(1S,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione MAVBUKOHERNHBQ-UHFFFAOYSA-N Lurasidone Impurity 24 MDYJLJKDGQUHSJ-HTWOXQOSSA-N Nsc237999 Lurasidone Impurity 2 Lurasidon hydrochloride iMpurity s,s-endo-lurasidone HCl Pregabalin Liraglutide Lurasidone hydrochloride

  • 4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione
  • lurasidone
  • (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
  • Lurasidone (SM13496)
  • (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione
  • urasidone
  • Lurasidone, >=98%
  • Lurasidone Base
  • (3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione
  • SM13496; SM-13496; SM 13496
  • Lurasidone Free base
  • Lurasindone
  • CS-327
  • 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-
  • (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
  • lurasidone USP/EP/BP
  • TIANFU-CHEM - lurasidone
  • (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinylChemicalbook]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
  • (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4
  • Lurasidone (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3- yl)piperazin-1-yl)methyl) cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)- dione
  • 367514-87-2
  • C28H36N4O2S
  • Pharmaceutical intermediate