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JAK3 Inhibitor

Product Name
JAK3 Inhibitor
CAS No.
211555-04-3
Chemical Name
JAK3 Inhibitor
Synonyms
CS-1516;whi-p154cas;JAK3 Inhibitor;JAK3 Inhibitor II WHI-P154;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR
CBNumber
CB22502881
Molecular Formula
C16H14BrN3O3
Formula Weight
376.2
MOL File
211555-04-3.mol
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JAK3 Inhibitor Property

Melting point:
230 °C
Boiling point:
470.3±45.0 °C(Predicted)
Density 
1.576±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble1mg/mL, clear (warmed)
pka
8.57±0.31(Predicted)
form 
powder
color 
white to brown
InChIKey
CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference
211555-04-3
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420104
Product name
JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem
Packaging
5MG
Price
$303
Updated
2024/03/01
TCI Chemical
Product number
W0013
Product name
WHI-P154
Packaging
10MG
Price
$139
Updated
2024/03/01
TCI Chemical
Product number
W0013
Product name
WHI-P154
Packaging
50MG
Price
$417
Updated
2024/03/01
Cayman Chemical
Product number
16178
Product name
WHI-P154
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
16178
Product name
WHI-P154
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
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JAK3 Inhibitor Chemical Properties,Usage,Production

Description

WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.

Uses

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.

Uses

WHI-P154 can act as antileukemic agent with apoptosis inducing activity.

Biochem/physiol Actions

WHI-P154 is a specific inhibitor of JAK3 (IC50 = 1.8 μM) with no inhibitory activity against JAK1 or JAK2. WHI-P154 enhances myogenic differentiation of C2C12 mouse myoblast cells, and induces differentiation of neural progenitor cells. The compound WHI-P154 dose dependently inhibits expression of iNOS and NO production in LPS-challenged macrophages.

in vitro

kinase assays show that whi-p154 is not a specific inhibitor. besides jak3, it also inhibits many other kinases, including egfr, abl, lck, src and vegfr. whi-p154 inhibits egfr with ic50 value of 4nm. the specificity of whi-p154 has not been shown in cell-based assays either [1].

storage

Store at RT

References

[1] changelian ps, moshinsky d, kuhn cf, flanagan me, munchhof mj, harris tm, whipple da, doty jl, sun j, kent cr, magnuson ks, perregaux dg, sawyer ps, kudlacz em. the specificity of jak3 kinase inhibitors. blood. 2008 feb 15;111(4):2155-7.
[2] narla rk, liu xp, myers de, uckun fm. 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. clin cancer res. 1998 jun;4(6):1405-14.

JAK3 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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JAK3 Inhibitor Suppliers

Canada 1 China 93 India 3 Japan 1 United Kingdom 2 United States 17 Global 117
VDM Biochemicals
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0330-2528181
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Cckinase, Inc.
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Aladdin Scientific
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View Lastest Price from JAK3 Inhibitor manufacturers

Career Henan Chemical Co
Product
JAK3 Inhibitor 211555-04-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-24

211555-04-3, JAK3 InhibitorRelated Search:

JAK3 INHIBITOR I 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL 2-Bromopropane 1-Bromo-3-methylbutane 2-Methylsulfonyl-4,6-dimethoxypyrimidine WHI-P97 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Tofacitinib citrate Stattic (+)-JQ1 ABT-199 ABT 737 Entinostat

  • JAK3 Inhibitor
  • 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
  • Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-
  • 4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154
  • 2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol
  • JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem
  • CS-1516
  • whi-p154cas
  • JAK3 Inhibitor II WHI-P154
  • Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR
  • 211555-04-3
  • Inhibitors
  • Inhibitor
  • JAK/STAT
  • JAK
  • STAT