3alpha-Akeboic acid
- Product Name
- 3alpha-Akeboic acid
- CAS No.
- 104777-61-9
- Chemical Name
- 3alpha-Akeboic acid
- Synonyms
- 3αAkebonoic acid;3α Akebonoic acid;3α-Akebonoic Acid;3alpha-Akeboic acid;3-Epiakebonoic acid;3alpha-Akebonoic acid;30-Noroleana-12,20(29)-dien-28-oic acid, 3-hydroxy-, (3α)-;(3alpha)-3-Hydroxy-30-noroleana-12,20(29)-dien-28-oic acid
- CBNumber
- CB22519373
- Molecular Formula
- C29H44O3
- Formula Weight
- 440.65786
- MOL File
- 104777-61-9.mol
3alpha-Akeboic acid Property
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
N-Bromosuccinimide Price
- Product number
- CFN99067
- Product name
- 3alpha-Akebonoicacid
- Packaging
- 5mg
- Price
- $593
- Updated
- 2021/12/16
- Product number
- CD32002921
- Product name
- 3-Epiakebonoicacid
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $930
- Updated
- 2021/12/16
3alpha-Akeboic acid Chemical Properties,Usage,Production
Description
3α-Akebonoic acid shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, it also shows significant in vitro α-glucosidase inhibitory activity. 3α-Akebonoic acid can interfer with presenilin-1 (PS1)/ β-site APP-cleaving enzyme 1 (BACE1) interaction and reduces Aβ production, the chemical interference of PS1/BACE1 interaction is a promising strategy for Alzheimer’s disease therapeutics.
Uses
3α-Akebonoic acid is a α-glucosidase inhibitor with an IC50 value of 0.035 mM. 3α-Akebonoic acid shows antibacterial activity and cytotoxicity[1].
target
Beta Amyloid | BACE
References
[1] Wang J, et al. Bioactive 30-noroleanane triterpenes from the pericarps of Akebia trifoliata. Molecules. 2014 Apr 4;19(4):4301-12. DOI:10.3390/molecules19044301
3alpha-Akeboic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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