ChemicalBook > CAS DataBase List > 2'-deoxy-2'-fluoro-2'-C-methylcytidine

2'-deoxy-2'-fluoro-2'-C-methylcytidine

Product Name
2'-deoxy-2'-fluoro-2'-C-methylcytidine
CAS No.
817204-33-4
Chemical Name
2'-deoxy-2'-fluoro-2'-C-methylcytidine
Synonyms
ethyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxylate;PSI 6130;R 1656;CS-1995;PSI-6130(R 1656);PSI-6130;PSI 6130;Sofosbuvir Impurity 121;PSI-6130, 10 mM in DMSO;PSI-6130;R 1656;PSI 6130;2'-Deoxy-2'-F-2'-C-methylcytidine
CBNumber
CB22525888
Molecular Formula
C10H14FN3O4
Formula Weight
259.23
MOL File
817204-33-4.mol
More
Less

2'-deoxy-2'-fluoro-2'-C-methylcytidine Property

Melting point:
216-218℃
Boiling point:
482.4±55.0 °C(Predicted)
Density 
1.67
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Methanol (Slightly), Water (Slightly)
pka
12.86±0.70(Predicted)
form 
Solid
color 
White to Light Brown
Stability:
Hygroscopic
InChI
InChI=1S/C10H14FN3O4/c1-10(11)7(16)5(4-15)18-8(10)14-3-2-6(12)13-9(14)17/h2-3,5,7-8,15-16H,4H2,1H3,(H2,12,13,17)/t5-,7-,8-,10-/m1/s1
InChIKey
NYPIRLYMDJMKGW-VPCXQMTMSA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@@](F)(C)[C@@H]1O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
13575
Product name
PSI-6130
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
13575
Product name
PSI-6130
Packaging
5mg
Price
$321
Updated
2024/03/01
TRC
Product number
P839680
Product name
PSI6130
Packaging
25mg
Price
$640
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND28816
Product name
2'-Deoxy-2'-fluoro-2'-C-methylcytidine
Packaging
2mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND28816
Product name
2'-Deoxy-2'-fluoro-2'-C-methylcytidine
Packaging
5mg
Price
$100
Updated
2021/12/16
More
Less

2'-deoxy-2'-fluoro-2'-C-methylcytidine Chemical Properties,Usage,Production

Description

PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; Ki = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC90s = 46.3, >100, >100, and >10 μM, respectively).

Uses

PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.

target

Hepatitis C Virus Nucleoside

References

[1] EISUKE MURAKAMI. Mechanism of activation of beta-D-2’-deoxy-2’-fluoro-2’-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.[J]. Antimicrobial Agents and Chemotherapy, 2007, 51 2: 503-509. DOI: 10.1128/aac.00400-06
[2] LIEVEN J STUYVER. Inhibition of hepatitis C replicon RNA synthesis by beta-D-2’-deoxy-2’-fluoro-2’-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.[J]. Antiviral Chemistry and Chemotherapy, 2006, 17 2: 79-87. DOI: 10.1177/095632020601700203

2'-deoxy-2'-fluoro-2'-C-methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2'-deoxy-2'-fluoro-2'-C-methylcytidine Suppliers

China 145 India 1 United Kingdom 1 United States 15 Global 162
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 2'-deoxy-2'-fluoro-2'-C-methylcytidine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
2'-deoxy-2'-fluoro-2'-C-methylcytidine 817204-33-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-26
Shenzhen Nexcon Pharmatechs Ltd.
Product
2'-deoxy-2'-fluoro-2'-C-methylcytidine 817204-33-4
Price
US $0.00-0.00/G
Min. Order
1G
Purity
97%
Supply Ability
2000
Release date
2025-06-04
Henan Fengda Chemical Co., Ltd
Product
2'-deoxy-2'-fluoro-2'-C-methylcytidine 817204-33-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22

817204-33-4, 2'-deoxy-2'-fluoro-2'-C-methylcytidineRelated Search:

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one 4-Pyridinecarboxamide, 3-chloro-N-methyl- 3-Pyridinecarboxamide, 4-chloro-N-methyl- ((2R,3S,4S)-3-(benzoyloxy)-4-fluoro-4-Methyl-5-oxotetrahydrofuran-2-yl)Methyl benzoate N4-Benzoylcytosine (2R)-2-Deoxy-2-fluoro-2-Methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate) 2'-C-Methyl-, 2',3',5'-tribenzoateuridine 3-Pyridinecarboxamide, 5-chloro-N-methyl- 2'-deoxy-2'-fluoro-2'-C-methyluridine HUMAN MDC (CCL22) 3-Aminobenzotrifluoride

  • (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine
  • PSI-6130;R 1656;PSI 6130
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyr
  • R 1656; R-1656; R1656; PSI6130; PSI 6130
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidine
  • PSI 6130
  • R 1656
  • ethyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxylate
  • ethyl 4-broMo-1-Methyl-pyrrole-2-carboxylate
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimi
  • 4-AMino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidin-2(1H)-one
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidin
  • 2'-Deoxy-2'-F-2'-C-methylcytidine
  • CS-1995
  • PSI-6130;PSI 6130
  • Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidine,817204-33-4
  • 2'-deoxy-2'-Fluoro-2'-methylcytidine
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one (sofosbuvir Impurity)
  • Sofosbuvir Impurity 121
  • 2'-C-methyl-2'-Fluoro-2'-deoxyCytidine
  • PSI-6130(R 1656)
  • (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine
  • PSI-6130, 10 mM in DMSO
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidine,PSI-6130
  • 817204-33-4
  • apis