methyl 6-amino-3,5-dibromopicolinate
- Product Name
- methyl 6-amino-3,5-dibromopicolinate
- CAS No.
- 443956-21-6
- Chemical Name
- methyl 6-amino-3,5-dibromopicolinate
- Synonyms
- methyl 6-amino-3,5-dibromopicolinate;Methyl 6-aMino-3,5-dibroMopyridine-2-carboxylate;6-Amino-3,5-dibromopyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 6-amino-3,5-dibromo-, methyl ester
- CBNumber
- CB22535876
- Molecular Formula
- C7H6Br2N2O2
- Formula Weight
- 309.94
- MOL File
- 443956-21-6.mol
methyl 6-amino-3,5-dibromopicolinate Property
- Boiling point:
- 366.0±37.0 °C(Predicted)
- Density
- 1.997
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.94±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- 455766
- Product name
- Methyl 6-Amino-3,5-dibromopyridine-2-carboxylate
- Packaging
- 25mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- M286020
- Product name
- Methyl6-Amino-3,5-dibromopyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- CS-W000757
- Product name
- Methyl6-amino-3,5-dibromopicolinate
- Purity
- 98.89%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CS-W000757
- Product name
- Methyl6-amino-3,5-dibromopicolinate
- Purity
- 98.89%
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- V5979
- Product name
- Methyl6-amino-3,5-dibromopicolinate
- Packaging
- 10g
- Price
- $323
- Updated
- 2021/12/16
methyl 6-amino-3,5-dibromopicolinate Chemical Properties,Usage,Production
Uses
Methyl 6-Amino-3,5-dibromopyridine-2-carboxylate is used as a reagent in the synthesis of imidazopyridines as Syk inhibitors. Also used as a reagent in the synthesis of quinoline, quinoxaline and naphthyridine derivatives as antibacterial agents.
Synthesis
36052-26-3
443956-21-6
178876-83-0
178876-82-9
General procedure for the synthesis of methyl 6-amino-3,5-dibromopyridine-2-carboxylate, methyl 6-amino-3-bromopyridine-2-carboxylate, and methyl 5-bromo-6-aminopyridine-2-carboxylate from methyl 6-aminopyridine-2-carboxylate: over a period of 30 min, a solution of chloroform (40 mL) with bromine (2.57 mL) was added slowly and dropwise to methyl 6-aminopyridine-2-carboxylate ( 6.92 g) in a solution of chloroform (300 mL). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was upsampled onto a silica gel column and purified by column chromatography (SiO2, heptane/ethyl acetate) to isolate three products: methyl 6-amino-5-bromo-pyridine-2-carboxylate (2 g, 19% yield), methyl 6-amino-3-bromo-pyridine-2-carboxylate (3 g, 29% yield) and methyl 6-amino-3,5-dibromopyridine-2-carboxylate (2.6 g, 18% yield).The 1H NMR (400 MHz, chloroform-d) data for methyl 6-amino-5-bromopyridine-2-carboxylate were as follows: δ 3.97 (s, 3H), 5.22 (br.s, 2H), 7.38 (d, J = 7.8 Hz, 1H), 7.79 (d, J = 7.8 Hz, 1H).
References
[1] Patent: WO2011/75591, 2011, A1. Location in patent: Page/Page column 95
[2] Patent: US2011/152312, 2011, A1. Location in patent: Page/Page column 40
methyl 6-amino-3,5-dibromopicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 6-amino-3,5-dibromopicolinate Suppliers
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from methyl 6-amino-3,5-dibromopicolinate manufacturers
- Product
- methyl 6-amino-3,5-dibromopicolinate 443956-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-14