3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 866775-09-9
- Chemical Name
- 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 3-aMino-6-broMopicolinate;Methyl 3-amino-6-bromopicolinate - [M25884];methyl 3-amino-6-bromopyridine-2-carboxylate;3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;2-Pyridinecarboxylic acid, 3-aMino-6-broMo-, Methyl ester
- CBNumber
- CB72465765
- Molecular Formula
- C7H7BrN2O2
- Formula Weight
- 231.05
- MOL File
- 866775-09-9.mol
3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Property
- Boiling point:
- 353.4±37.0 °C(Predicted)
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.07±0.10(Predicted)
- form
- powder
- color
- Yellow to dark yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M331223
- Product name
- Methyl3-Amino-6-bromopicolinate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3613AC
- Product name
- Methyl3-amino-6-bromopicolinate
- Packaging
- 1g
- Price
- $458
- Updated
- 2021/12/16
- Product number
- HCH0369262
- Product name
- METHYL-3-AMINO-6-BROMOPICOLINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.81
- Updated
- 2021/12/16
- Product number
- A230295
- Product name
- Methyl3-amino-6-bromopicolinate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 69R0901
- Product name
- 3-Amino-6-bromo-pyridine-2-carboxylicacidmethylester
- Purity
- 97%
- Packaging
- 100mg
- Price
- $98
- Updated
- 2021/12/16
3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 3-amino-6-bromopicolinate is a useful reactant for organic reactions and synthesis.
Synthesis
36052-27-4
866775-09-9
Step 2: Methyl 3-aminopyridine-2-carboxylate (17 g, 111.8 mmol) was dissolved in a solvent mixture of water (288 mL) and 2M sulfuric acid (58 mL) and stirred at room temperature until completely dissolved. Subsequently, a solution of bromine (5.76 mL, 111.8 mmol) in acetic acid (43 mL) was added slowly dropwise, and the reaction continued to be stirred at room temperature for 4 hours after completion of the dropwise addition. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 6 with 2N aqueous sodium hydroxide solution. the aqueous phase was extracted twice with ethyl acetate (in equal amounts each time), the organic layers were combined and dried over anhydrous sodium sulfate. The organic solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent to afford methyl 3-amino-6-bromopyridine-2-carboxylate (19.2 g, 74% yield) as a white solid. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 3.94 (3H, s), 5.81 (2H, brs), 6.93 (1H, d, J = 8.72 Hz), 7.32 (1H, d, J = 8.71 Hz).
References
[1] Patent: EP2975031, 2016, A1. Location in patent: Paragraph 1071
[2] Patent: WO2005/97805, 2005, A1. Location in patent: Page/Page column 54
[3] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0687; 0688
[4] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 164
[5] Patent: US2013/210819, 2013, A1. Location in patent: Paragraph 0252-0253
3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 866775-09-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29