ChemicalBook > CAS DataBase List > 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Product Name
3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
CAS No.
866775-09-9
Chemical Name
3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
Synonyms
Methyl 3-aMino-6-broMopicolinate;Methyl 3-amino-6-bromopicolinate - [M25884];methyl 3-amino-6-bromopyridine-2-carboxylate;3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;2-Pyridinecarboxylic acid, 3-aMino-6-broMo-, Methyl ester
CBNumber
CB72465765
Molecular Formula
C7H7BrN2O2
Formula Weight
231.05
MOL File
866775-09-9.mol
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3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Property

Boiling point:
353.4±37.0 °C(Predicted)
Density 
1.662±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-0.07±0.10(Predicted)
form 
powder
color 
Yellow to dark yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M331223
Product name
Methyl3-Amino-6-bromopicolinate
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
3613AC
Product name
Methyl3-amino-6-bromopicolinate
Packaging
1g
Price
$458
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0369262
Product name
METHYL-3-AMINO-6-BROMOPICOLINATE
Purity
95.00%
Packaging
5MG
Price
$504.81
Updated
2021/12/16
Ambeed
Product number
A230295
Product name
Methyl3-amino-6-bromopicolinate
Purity
97%
Packaging
100mg
Price
$69
Updated
2021/12/16
J&W Pharmlab
Product number
69R0901
Product name
3-Amino-6-bromo-pyridine-2-carboxylicacidmethylester
Purity
97%
Packaging
100mg
Price
$98
Updated
2021/12/16
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3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 3-amino-6-bromopicolinate is a useful reactant for organic reactions and synthesis.

Synthesis

36052-27-4

866775-09-9

Step 2: Methyl 3-aminopyridine-2-carboxylate (17 g, 111.8 mmol) was dissolved in a solvent mixture of water (288 mL) and 2M sulfuric acid (58 mL) and stirred at room temperature until completely dissolved. Subsequently, a solution of bromine (5.76 mL, 111.8 mmol) in acetic acid (43 mL) was added slowly dropwise, and the reaction continued to be stirred at room temperature for 4 hours after completion of the dropwise addition. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 6 with 2N aqueous sodium hydroxide solution. the aqueous phase was extracted twice with ethyl acetate (in equal amounts each time), the organic layers were combined and dried over anhydrous sodium sulfate. The organic solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent to afford methyl 3-amino-6-bromopyridine-2-carboxylate (19.2 g, 74% yield) as a white solid. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 3.94 (3H, s), 5.81 (2H, brs), 6.93 (1H, d, J = 8.72 Hz), 7.32 (1H, d, J = 8.71 Hz).

References

[1] Patent: EP2975031, 2016, A1. Location in patent: Paragraph 1071
[2] Patent: WO2005/97805, 2005, A1. Location in patent: Page/Page column 54
[3] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0687; 0688
[4] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 164
[5] Patent: US2013/210819, 2013, A1. Location in patent: Paragraph 0252-0253

3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers

Career Henan Chemica Co
Product
3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 866775-09-9
Price
US $1.00/KG
Min. Order
1KG
Purity
MIn98%HPLC/LC
Supply Ability
100KGS
Release date
2020-10-29

866775-09-9, 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTERRelated Search:

5-CHLORO-1H-INDAZOL-3-YLAMINE (3-AMINO-5-NITROPHENYL)METHANOL 3-AMINO-4-CYANOPYRIDINE 3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE 3-aMino-5-broMo-4-chloropyridine 3-Amino-6-trifluoromethyl-pyridin-2-ol 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 3-amino-6-chloropyrazine-2-carboxylic acid 3-AMINO-4-METHOXYPYRIDINE 3-AMINO-3-(4-CYANOPHENYL)PROPANOIC ACID 3-Amino-5-chloropyridin-2-ol HCl (3-aminopyrazin-2-yl)methanol 3-Amino-3-(4-methoxyphenyl)propionic acid 3-PYRIDINAMINE, 6-(1-METHYLETHYL)- 3-AMINO-5-HYDROXYBENZOIC ACID 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

  • 3-AMINO-6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
  • methyl 3-amino-6-bromopyridine-2-carboxylate
  • Methyl 3-aMino-6-broMopicolinate
  • 2-Pyridinecarboxylic acid, 3-aMino-6-broMo-, Methyl ester
  • Methyl 3-amino-6-bromopicolinate - [M25884]
  • 866775-09-9