CP 91149

Product Name: CP 91149
CAS No.: 186392-40-5
Chemical Name: CP 91149
Synonyms: CS-231;CP 91149;CP-91149 CP91149;CP 91149 USP/EP/BP;CP-91149, 10 mM in DMSO;5-chloro-N-((2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide;5-Chloro-N-[(1S,2R)-3-(diMethylaMino)-2-hydroxy-3-oxo-1-(phenylMethyl)propyl]-1H-indole-2-carboxaMide;[R-(R*,S*)]-5-Chloro-N-[3-(diMethylaMino)-2-hydroxy-3-oxo- 1-(phenylMethyl)propyl]-1H-indole-2-carboxaMide
CBNumber: CB22543734
Molecular Formula: C21H21ClN3O3
Formula Weight: 398.86274
MOL File: 186392-40-5.mol

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CP 91149 Property

Melting point:: 190-192°C
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
color: white to off-white
Stability:: Hygroscopic

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0104
Product name: CP-91149
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0104
Product name: CP-91149
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $576
Updated: 2024/03/01

Cayman Chemical

Product number: 17709
Product name: CP 91,149
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17709
Product name: CP 91,149
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17709
Product name: CP 91,149
Purity: ≥98%
Packaging: 25mg
Price: $211
Updated: 2024/03/01

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CP 91149 Chemical Properties,Usage,Production

Description

CP 91,149 is an inhibitor of human liver glycogen phosphorylase a (LGPa), muscle glycogen phosphorylase a (MGPa), and MGPb (IC₅₀s = 0.13, 0.2, and 0.3 μM, respectively, in the presence of glucose). CP 91,149 is 5- to 10-fold less potent in the absence of glucose. In vitro, it inhibits glucagon-stimulated glycogenolysis in primary human hepatocytes (IC₅₀ = 2.1 μM) and increases glycogen synthesis in rat hepatocytes at a concentration of 2.5 μM in the presence of 5 mM glucose. CP 91,149 inhibits brain GP (IC₅₀ = 0.5 μM) and, at a concentration of 30 μM, inhibits glycogen accumulation and proliferation of A549 non-small cell lung carcinoma (NSCLC) cells that express endogenous brain GP. In vivo, CP 91,149 (25 mg/kg, p.o.) lowers the plasma glucose level in diabetic ob/ob mice within 3 hours of administration without producing hypoglycemia, but has no effect on normoglycemic, non-diabetic mice.

Chemical Properties

White Solid

Uses

Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. Antitumor agent.

Biochem/physiol Actions

CP-91149 is a selective glycogen phosphorylase inhibitor.

in vitro

cp-91149 treatment suppressed glycogenolysis stimulated by glucagon in in primary human hepatocytes and isolated rat hepatocytes with ic50 value of 2.1 μm and 10–100 μm, respectively 1. inhibition of phosphorylase a by cp-91149 resulted in activation of glycogen synthase and translocation of the protein from a soluble to a particulate fraction, which mimicked the insulin- stimulated glycogen synthesis 2.

in vivo

treatment of cp-91149 on diabetic ob/ob mice at a dosage of 25–50 mg/kg was shown to lead to a rapid glucose lowering but did not change glucose levels in normoglycemic, nondiabetic mice 1.

target

GP

References

1. martin wh, hoover dj, armento sj, et al. discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. proceedings of the national academy of sciences of the united states of america. 1998;95(4):1776-1781.2. aiston s, coghlan mp, agius l. inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis. european journal of biochemistry / febs. 2003;270(13):2773-2781.

CP 91149 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP 91149 Suppliers

Canada 1 China 85 United Kingdom 1 United States 15 Global 102

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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BOC Sciences

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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
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Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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TargetMol Chemicals Inc.

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United States Biological

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ApexBio Technology

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Cayman Chemical Company

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United States Biological

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MedChemExpress

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Riedel-de Haen AG

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View Lastest Price from CP 91149 manufacturers

Career Henan Chemical Co

Product: CP 91149 186392-40-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-14

186392-40-5, CP 91149Related Search:

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CS-231

[R-(R*,S*)]-5-Chloro-N-[3-(diMethylaMino)-2-hydroxy-3-oxo- 1-(phenylMethyl)propyl]-1H-indole-2-carboxaMide

5-Chloro-N-[(1S,2R)-3-(diMethylaMino)-2-hydroxy-3-oxo-1-(phenylMethyl)propyl]-1H-indole-2-carboxaMide

CP 91149

5-chloro-N-((2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide

CP 91149 USP/EP/BP

CP-91149 CP91149

CP-91149, 10 mM in DMSO

186392-40-5

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