ChemicalBook > CAS DataBase List > 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone

1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone

Product Name: 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
CAS No.: 41332-24-5
Chemical Name: 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
Synonyms: Z160;39-1B4;CS-2371;NP 118809;NP118809 (39-1B4;39-1B4; NP-118809;NP 118809;NP118809;NP118809, 10 mM in DMSO;1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3;1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
CBNumber: CB22544418
Molecular Formula: C32H32N2O
Formula Weight: 460.61
MOL File: 41332-24-5.mol

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1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone Property

Boiling point:: 618.9±55.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO : 50 mg/mL (108.55 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 5.99±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D491935
Product name: 1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
Packaging: 500mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-1361
Product name: NP118809
Purity: 98.62%
Packaging: 500mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 3934AH
Product name: 1-(4-Benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one
Packaging: 100mg
Price: $157
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22501
Product name: 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
Packaging: 100mg
Price: $230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22501
Product name: 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
Packaging: 250mg
Price: $280
Updated: 2021/12/16

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1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone Chemical Properties,Usage,Production

Uses

An analog of Cinnarizine (C465300), a calcium channel blocker as anti-inflammatory agent.

Synthesis

606-83-7

841-77-0

41332-24-5

Procedure for the synthesis of 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine: to an anhydrous dichloromethane (40 mL) solution of 1-(Diphenylmethyl)piperazine (2.08 mmol), under nitrogen protection, was added 3,3 -diphenylpropionic acid (0.472 g, 2.08 mmol). Subsequently, EDC (0.797 g, 4.16 mmol) and a catalytic amount of DMAP were added to the reaction mixture, which was stirred overnight at room temperature under nitrogen atmosphere. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was dissolved in a solvent mixture of ethyl acetate and water (10:1, 150 mL). The organic phase was washed sequentially with water (30 mL, twice) and 10% NaOH solution (30 mL), dried with anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The crude product obtained was purified by column chromatography with the eluent being a mixture of petroleum ether and ethyl acetate (3:1), and the target product 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine was finally obtained in 78% yield.

in vivo

NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model^[1]. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model^[2].

IC 50

N-type calcium channel: 0.11 μM (IC₅₀); L-type calcium channel: 12.2 μM (IC₅₀)

References

[1] Patent: US2004/259866, 2004, A1
[2] Patent: US6951862, 2005, B2
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 22, p. 6467 - 6472
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1378 - 1383

1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone manufacturers

Career Henan Chemical Co

Product: 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone 41332-24-5
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-01-08

41332-24-5, 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanoneRelated Search:

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1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone

1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine

39-1B4

NP 118809

Z160

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39-1B4; NP-118809

NP 118809;NP118809

CS-2371

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1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3

NP118809, 10 mM in DMSO

41332-24-5

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