MK8245
- Product Name
- MK8245
- CAS No.
- 1030612-90-8
- Chemical Name
- MK8245
- Synonyms
- CS-1662;]-5-isoxazoL;]-2H-tetrazoL;MK 8245;MK8245;e-2-acetic acid;MK8245 USP/EP/BP;5-[3-[4-(2-Bromo-5-fL;MK8245;MK-8245;MK 8245;uorophenoxy)-1-piperidinyL;5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
- CBNumber
- CB22546432
- Molecular Formula
- C17H16BrFN6O4
- Formula Weight
- 467.25
- MOL File
- 1030612-90-8.mol
MK8245 Property
- Boiling point:
- 698.3±65.0 °C(Predicted)
- Density
- 1.82
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- ≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 2.85±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H242Heating may cause a fire
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234Keep only in original container.
P235Keep cool.
P240Ground/bond container and receiving equipment.
P370+P378In case of fire: Use … for extinction.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- 901744
- Product name
- 2-(5-(3-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid
- Packaging
- 100MG
- Price
- $114
- Updated
- 2023/06/20
- Product number
- 29421
- Product name
- MK-8245
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 29421
- Product name
- MK-8245
- Packaging
- 25mg
- Price
- $836
- Updated
- 2024/03/01
- Product number
- 29421
- Product name
- MK-8245
- Packaging
- 5mg
- Price
- $268
- Updated
- 2024/03/01
- Product number
- 29421
- Product name
- MK-8245
- Packaging
- 10mg
- Price
- $435
- Updated
- 2024/03/01
MK8245 Chemical Properties,Usage,Production
Description
MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).
Uses
This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.
target
SCD1 (human)
References
[1] oballa rm, belair l, black wc, bleasby k, chan cc, desroches c, du x, gordon r, guay j, guiral s, hafey mj, hamelin e, huang z, kennedy b, lachance n, landry f, li cs, mancini j, normandin d, pocai a, powell da, ramtohul yk, skorey k, srensen d, sturkenboom w, styhler a, waddleton dm, wang h, wong s, xu l, zhang l. development of a liver-targeted stearoyl-coa desaturase (scd) inhibitor (mk-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. j med chem. 2011 jul 28;54(14):5082-96.
[2] lachance n, guiral s, huang z, leclerc jp, li cs, oballa rm, ramtohul yk, wang h, wu j, zhang l. discovery of potent and liver-selective stearoyl-coa desaturase (scd) inhibitors in an acyclic linker series. bioorg med chem lett. 2012 jan 1;22(1):623-7.
MK8245 Preparation Products And Raw materials
Raw materials
Preparation Products
MK8245 Suppliers
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View Lastest Price from MK8245 manufacturers
- Product
- MK8245 1030612-90-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-16