ChemicalBook > CAS DataBase List > Methyl 2,3-dichloropropionate

Methyl 2,3-dichloropropionate

Product Name
Methyl 2,3-dichloropropionate
CAS No.
3674-09-7
Chemical Name
Methyl 2,3-dichloropropionate
Synonyms
2,3-dichloropropionate;METHYL-A,B-DICHLOROPROPIONATE;METHYL 2,3-DICHLOROPROPIONATE;Methyl 2,3-dichloropropanoate;Methyl2,3-Dichloropropionate>Methyl 2,3-dichloropropionate,98%;METHYL ALPHA,BETA-DICHLOROPROPIONATE;2,3-dichloro-propanoicacimethylester;2,3-DICHLOROPROPIONIC ACID METHYL ESTER;Methyl 2,3-dichloropropionate,70%,tech.
CBNumber
CB2257329
Molecular Formula
C4H6Cl2O2
Formula Weight
157
MOL File
3674-09-7.mol
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Methyl 2,3-dichloropropionate Property

Boiling point:
52-55 °C/2 mmHg (lit.)
Density 
1.325 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.453(lit.)
Flash point:
145 °F
storage temp. 
Store below +30°C.
solubility 
Soluble in ether, acetone, ethanol.
color 
Colorless to Almost colorless
BRN 
1701891
InChI
InChI=1S/C4H6Cl2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3
InChIKey
OFHMODDLBXETIK-UHFFFAOYSA-N
SMILES
C(OC)(=O)C(Cl)CCl
CAS DataBase Reference
3674-09-7(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, 2,3-dichloro-, methyl ester(3674-09-7)
EPA Substance Registry System
Propanoic acid, 2,3-dichloro-, methyl ester (3674-09-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-10
Safety Statements 
23-24/25-37/39-26-16
RIDADR 
1993
WGK Germany 
3
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18319
Product name
Methyl 2,3-dichloropropionate
Purity
for synthesis
Packaging
10ml
Price
$44.2
Updated
2024/03/01
TCI Chemical
Product number
D0408
Product name
Methyl 2,3-Dichloropropionate
Purity
>95.0%(GC)
Packaging
10g
Price
$26
Updated
2024/03/01
Alfa Aesar
Product number
B21993
Product name
Methyl 2,3-dichloropropionate, 98%
Packaging
25g
Price
$46.65
Updated
2024/03/01
Alfa Aesar
Product number
B21993
Product name
Methyl 2,3-dichloropropionate, 98%
Packaging
100g
Price
$102.65
Updated
2024/03/01
Alfa Aesar
Product number
B21993
Product name
Methyl 2,3-dichloropropionate, 98%
Packaging
500g
Price
$396.65
Updated
2024/03/01
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Methyl 2,3-dichloropropionate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.

Application

Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline.

Synthesis

Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98.

Methyl 2,3-dichloropropionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2,3-dichloropropionate Suppliers

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View Lastest Price from Methyl 2,3-dichloropropionate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Methyl 2,3-dichloropropanoate 3674-09-7
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Hebei Guanlang Biotechnology Co., Ltd.
Product
Methyl 2,3-dichloropropionate 3674-09-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2023-02-15
Puyang Huicheng Electronic Materials Co., Ltd.
Product
Methyl 2,3-dichloropropionate 3674-09-7
Price
US $100.00/g
Min. Order
1000g
Purity
98%
Supply Ability
10tons
Release date
2020-06-10

3674-09-7, Methyl 2,3-dichloropropionateRelated Search:

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  • METHYL 2,3-DICHLOROPROPIONATE
  • METHYL-A,B-DICHLOROPROPIONATE
  • METHYL ALPHA,BETA-DICHLOROPROPIONATE
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  • METHYL-2,3-DICHLOROPROPIONATE, 1000MG, N EAT
  • Methyl 2,3-dichloropropionate, tech., 70%
  • Propanoic acid, 2,3-dichloro-, methyl ester
  • 2,3-dichloro-propanoic acid methyl ester
  • Methyl 2,3-dichloropropionate,98%
  • Methyl 2,3-dichloropropionate,70%,tech.
  • Methyl 2,3-dichloropropionate, tech., 70% 25ML
  • METHYL 2,3-DICHLOROPROPIONATE FOR SYNTHE
  • Methyl2,3-Dichloropropionate&gt
  • 2,3-dichloropropionate
  • Propanoic acid, 2,3-dichloro-, methyl ester (9CI, ACI)
  • 2,3-dichloro-Propanoic acid methyl ester (9CI ACI)
  • 3674-09-7
  • 648-19-2
  • 674-09-7
  • 3674-09-07
  • ClCH2CHClCOOCH3
  • Alpha Sort
  • M
  • MAlphabetic
  • META - METH
  • Volatiles/ Semivolatiles