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LEU-LEU METHYL ESTER HYDROBROMIDE

Product Name
LEU-LEU METHYL ESTER HYDROBROMIDE
CAS No.
16689-14-8
Chemical Name
LEU-LEU METHYL ESTER HYDROBROMIDE
Synonyms
LLME · HBr;H-Leu-Leu-OMe;Leu-Leu-Ome, HBr;H-LEU-LEU-OME HBR;LEU-LEU METHYL ESTER HYDROBROMIDE;Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl;HLeuLeuOMe . HBr,H Leu Leu OMe . HBr;L-Leucyl-L-Leucine methyl ester hydrobromide;Leu-Leu methyl ester hydrobromide >=97% (TLC);(S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrobromide
CBNumber
CB2259808
Molecular Formula
C13H27BrN2O3
Formula Weight
339.27
MOL File
16689-14-8.mol
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LEU-LEU METHYL ESTER HYDROBROMIDE Property

storage temp. 
−20°C
solubility 
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L7393
Product name
Leu-Leu methyl ester hydrobromide
Purity
≥97% (TLC)
Packaging
500mg
Price
$342
Updated
2024/03/01
Chem-Impex
Product number
08813
Product name
Leu-Leu-OMe·HBr,97%(TLC)
Purity
97%(TLC)
Packaging
5G
Price
$409.64
Updated
2021/12/16
Chem-Impex
Product number
08813
Product name
Leu-Leu-OMe·HBr,97%(TLC)
Purity
97%(TLC)
Packaging
250MG
Price
$53.2
Updated
2021/12/16
Chem-Impex
Product number
08813
Product name
Leu-Leu-OMe·HBr,≥97%(TLC)
Purity
≥97%(TLC)
Packaging
1G
Price
$105.12
Updated
2021/12/16
Crysdot
Product number
CD22004403
Product name
(S)-Methyl2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoatehydrobromide
Purity
95+%
Packaging
5g
Price
$436
Updated
2021/12/16
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LEU-LEU METHYL ESTER HYDROBROMIDE Chemical Properties,Usage,Production

Description

Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4? LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4

Uses

H-Leu-Leu-OMe·HBr is a useful research chemical compound used in the preparation of octapeptide derivatives and intermediates.

References

1) Maejima et al. (2013), Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury; EMBO J., 32 2336 2) Fujita et al. (2013), Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin; J. Cell Biol., 203 115 3) Chauhan et al. (2016), TRIMS and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-directed Autophagy in Endomembrane Damage Homeostasis; Dev. Cell, 39 13 4) Otomo and Yoshimori (2017), Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery; Methods Mol. Biol. 1594 141 5) Melo et al. (2011), Lysosomal membrane permeabilization induces cell death in human mast cells; Scand. J. Immunol., 74 354

LEU-LEU METHYL ESTER HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LEU-LEU METHYL ESTER HYDROBROMIDE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
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15848
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GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
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60
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
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19915
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Nanjing TGpeptide Biotechnology Co.,Ltd.
Tel
18115476705
Email
sales@tgpeptide.com
Country
China
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3189
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Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
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China
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44894
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TCI (Shanghai) Chemical Trading Co., Ltd.
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021-61109150
Fax
021-61105897
Email
sales@tcisct.com
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China
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31187
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Shanghai Universal Biotech Co.,Ltd
Tel
18768175414
Email
gaojun@univ-bio.com
Country
China
ProdList
24998
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58
Nanjing Yuanpeptide Biotech Co.,Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
Country
China
ProdList
2977
Advantage
58

16689-14-8, LEU-LEU METHYL ESTER HYDROBROMIDERelated Search:


  • H-LEU-LEU-OME HBR
  • LEU-LEU METHYL ESTER HYDROBROMIDE
  • H-Leu-Leu-OMe
  • LLME · HBr
  • Leu-Leu-Ome, HBr
  • (S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrobromide
  • Leu-Leu methyl ester hydrobromide >=97% (TLC)
  • L-Leucyl-L-Leucine methyl ester hydrobromide
  • Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl
  • HLeuLeuOMe . HBr,H Leu Leu OMe . HBr
  • 16689-14-8
  • C13H27BrN2O3
  • C13H26N2O3HBr
  • Dipeptides
  • Dipeptides and Tripeptides
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • Dipeptides
  • Dipeptides and Tripeptides
  • Peptides