LEU-LEU METHYL ESTER HYDROBROMIDE
- Product Name
- LEU-LEU METHYL ESTER HYDROBROMIDE
- CAS No.
- 16689-14-8
- Chemical Name
- LEU-LEU METHYL ESTER HYDROBROMIDE
- Synonyms
- LLME · HBr;H-Leu-Leu-OMe;Leu-Leu-Ome, HBr;H-LEU-LEU-OME HBR;LLOMe hydrobromide;H-Leu-Leu-OMe hydrobromide;LEU-LEU METHYL ESTER HYDROBROMIDE;Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl;HLeuLeuOMe . HBr,H Leu Leu OMe . HBr;L-Leucyl-L-Leucine methyl ester hydrobromide
- CBNumber
- CB2259808
- Molecular Formula
- C13H27BrN2O3
- Formula Weight
- 339.27
- MOL File
- 16689-14-8.mol
LEU-LEU METHYL ESTER HYDROBROMIDE Property
- storage temp.
- −20°C
- solubility
- Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- L7393
- Product name
- Leu-Leu methyl ester hydrobromide
- Purity
- ≥97% (TLC)
- Packaging
- 500mg
- Price
- $342
- Updated
- 2024/03/01
- Product number
- 08813
- Product name
- Leu-Leu-OMe·HBr,97%(TLC)
- Purity
- 97%(TLC)
- Packaging
- 5G
- Price
- $409.64
- Updated
- 2021/12/16
- Product number
- 08813
- Product name
- Leu-Leu-OMe·HBr,97%(TLC)
- Purity
- 97%(TLC)
- Packaging
- 250MG
- Price
- $53.2
- Updated
- 2021/12/16
- Product number
- 08813
- Product name
- Leu-Leu-OMe·HBr,≥97%(TLC)
- Purity
- ≥97%(TLC)
- Packaging
- 1G
- Price
- $105.12
- Updated
- 2021/12/16
- Product number
- CD22004403
- Product name
- (S)-Methyl2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoatehydrobromide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $436
- Updated
- 2021/12/16
LEU-LEU METHYL ESTER HYDROBROMIDE Chemical Properties,Usage,Production
Description
Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4? LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4
Uses
H-Leu-Leu-OMe·HBr is a useful research chemical compound used in the preparation of octapeptide derivatives and intermediates.
References
1) Maejima et al. (2013), Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury; EMBO J., 32 2336 2) Fujita et al. (2013), Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin; J. Cell Biol., 203 115 3) Chauhan et al. (2016), TRIMS and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-directed Autophagy in Endomembrane Damage Homeostasis; Dev. Cell, 39 13 4) Otomo and Yoshimori (2017), Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery; Methods Mol. Biol. 1594 141 5) Melo et al. (2011), Lysosomal membrane permeabilization induces cell death in human mast cells; Scand. J. Immunol., 74 354
LEU-LEU METHYL ESTER HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
LEU-LEU METHYL ESTER HYDROBROMIDE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71