ChemicalBook > CAS DataBase List > LEU-LEU METHYL ESTER HYDROBROMIDE

LEU-LEU METHYL ESTER HYDROBROMIDE

Product Name: LEU-LEU METHYL ESTER HYDROBROMIDE
CAS No.: 16689-14-8
Chemical Name: LEU-LEU METHYL ESTER HYDROBROMIDE
Synonyms: LLME · HBr;H-Leu-Leu-OMe;Leu-Leu-Ome, HBr;H-LEU-LEU-OME HBR;LLOMe hydrobromide;H-Leu-Leu-OMe hydrobromide;LEU-LEU METHYL ESTER HYDROBROMIDE;Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl;HLeuLeuOMe . HBr,H Leu Leu OMe . HBr;L-Leucyl-L-Leucine methyl ester hydrobromide
CBNumber: CB2259808
Molecular Formula: C13H27BrN2O3
Formula Weight: 339.27
MOL File: 16689-14-8.mol

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LEU-LEU METHYL ESTER HYDROBROMIDE Property

storage temp.: −20°C
solubility: Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L7393
Product name: Leu-Leu methyl ester hydrobromide
Purity: ≥97% (TLC)
Packaging: 500mg
Price: $367
Updated: 2025/07/31

Chem-Impex

Product number: 08813
Product name: Leu-Leu-OMe·HBr,97%(TLC)
Purity: 97%(TLC)
Packaging: 250MG
Price: $53.2
Updated: 2021/12/16

Chem-Impex

Product number: 08813
Product name: Leu-Leu-OMe·HBr,≥97%(TLC)
Purity: ≥97%(TLC)
Packaging: 1G
Price: $105.12
Updated: 2021/12/16

Chem-Impex

Product number: 08813
Product name: Leu-Leu-OMe·HBr,97%(TLC)
Purity: 97%(TLC)
Packaging: 5G
Price: $409.64
Updated: 2021/12/16

Crysdot

Product number: CD22004403
Product name: (S)-Methyl2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoatehydrobromide
Purity: 95+%
Packaging: 5g
Price: $436
Updated: 2021/12/16

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LEU-LEU METHYL ESTER HYDROBROMIDE Chemical Properties,Usage,Production

Description

Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4? LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4

Uses

H-Leu-Leu-OMe·HBr is a useful research chemical compound used in the preparation of octapeptide derivatives and intermediates.

References

[1] IKUKO MAEJIMA. Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury.[J]. EMBO Journal, 2013, 32 17: 2336-2347. DOI:10.1038/emboj.2013.171
[2] NAONOBU FUJITA. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.[J]. Journal of Cell Biology, 2013, 203 1: 115-128. DOI:10.1083/jcb.201304188
[3] S. CHAUHAN. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.[J]. Developmental cell, 2016, 1 1: 13-27. DOI:10.1016/j.devcel.2016.08.003
[4] TAKANOBU OTOMO Tamotsu Y. Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery.[J]. Methods in molecular biology, 2017, 1594: 141-149. DOI:10.1007/978-1-4939-6934-0\_8
[5] F R MELO. Lysosomal membrane permeabilization induces cell death in human mast cells.[J]. Scandinavian Journal of Immunology, 2011, 74 4: 354-362. DOI:10.1111/j.1365-3083.2011.02589.x

LEU-LEU METHYL ESTER HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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16689-14-8, LEU-LEU METHYL ESTER HYDROBROMIDERelated Search:

3-METHYLADENINE Xanthohumol ROTTLERIN Rapamycin H-LEU-LEU-OH LEU-LEU METHYL ESTER HYDROBROMIDE DL-LEU-DL-LEU

H-LEU-LEU-OME HBR

LEU-LEU METHYL ESTER HYDROBROMIDE

H-Leu-Leu-OMe

LLME · HBr

Leu-Leu-Ome, HBr

(S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrobromide

Leu-Leu methyl ester hydrobromide >=97% (TLC)

L-Leucyl-L-Leucine methyl ester hydrobromide

Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl

HLeuLeuOMe . HBr,H Leu Leu OMe . HBr

H-Leu-Leu-OMe hydrobromide

LLOMe hydrobromide

L-Leucine, L-leucyl-,methyl ester, monohydrobromide (9CI)

16689-14-8

C13H27BrN2O3

C13H26N2O3HBr

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Amino Acids and Peptides

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