ChemicalBook > CAS DataBase List > 5-Chloro-2-nitrotoluene

5-Chloro-2-nitrotoluene

Application

Product Name: 5-Chloro-2-nitrotoluene
CAS No.: 5367-28-2
Chemical Name: 5-Chloro-2-nitrotoluene
Synonyms: 5-Chloro-2-nit;3-chloro-6-nitrotoluene;5-CHLORO-2-NITROTOLUENE;5-chloro-2-nitro-toluen;2-Nitro-5-chlorotoluene;Toluene, 5-chloro-2-nitro-;5-Chloro-2-nitrotoluene,98%;5-Chloro-2-nitrotoluene >3-Methyl-4-nitrochlorobenzene;1-Chloro-3-methyl-4-nitrobenzene
CBNumber: CB2265005
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 5367-28-2.mol

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5-Chloro-2-nitrotoluene Property

Melting point:: 27-30 °C (lit.)
Boiling point:: 124-126 °C (16 mmHg)
Density: 1.32
refractive index: 1.57-1.572
Flash point:: 202 °F
storage temp.: Inert atmosphere,Room Temperature
form: powder to lump
color: White to Light yellow
Water Solubility: insoluble
CAS DataBase Reference: 5367-28-2(CAS DataBase Reference)
NIST Chemistry Reference: 5-Chloro-2-nitrotoluene(5367-28-2)

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-36-36/37/38-20/21/22-52/53
Safety Statements: 26-36-36/37/39-61
RIDADR: UN 3457 6.1/PG 3
WGK Germany: 3
RTECS: XS9134000
HazardClass: 6.1
PackingGroup: III
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 226653
Product name: 5-Chloro-2-nitrotoluene
Purity: 98%
Packaging: 25g
Price: $21.45
Updated: 2025/07/31

TCI Chemical

Product number: C2586
Product name: 5-Chloro-2-nitrotoluene
Purity: >97.0%(GC)
Packaging: 5g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: C2586
Product name: 5-Chloro-2-nitrotoluene
Purity: >97.0%(GC)
Packaging: 25g
Price: $70
Updated: 2025/07/31

TRC

Product number: C382403
Product name: 5-Chloro-2-nitrotoluene
Packaging: 10g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J92361
Product name: 5-Chloro-2-nitrotoluene
Packaging: 500g
Price: $180
Updated: 2021/12/16

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5-Chloro-2-nitrotoluene Chemical Properties,Usage,Production

Application

5-Chloro-2-nitrotoluene is an organic intermediate that can be obtained by nitrifying o-chlorotoluene.

Chemical Properties

clear yellow liquid

General Description

The cytotoxicity of 5-chloro-2-nitrotoluene, an analog of chlorphenamidine, was studied.

Synthesis

108-41-8

5367-28-2

38939-88-7

General procedure for the synthesis of 5-chloro-2-nitrotoluene and 3-chloro-4-nitrotoluene from 3-chlorotoluene: Concentrated nitric acid (16 mL) was added slowly and dropwise at 0°C to a solution of glacial acetic acid (20 mL) containing 3-chlorotoluene (3 mL, 25.4 mmol) and concentrated sulfuric acid (6 mL). The reaction mixture was stirred at room temperature for 24 hours. Subsequently, the reaction mixture was poured into ice water and liquid-liquid partitioned with ether. After separating the aqueous phase, the aqueous phase was extracted twice with ether. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The yellow oily crude product obtained was purified by silica gel column chromatography and after two rapid chromatographic separations, 1.22 g (14% yield) of 5-chloro-2-nitrotoluene (yellow oily) and 3.39 g (39% yield) of 3-chloro-4-nitrotoluene were obtained.

References

[1] Patent: US2012/15962, 2012, A1. Location in patent: Page/Page column 83
[2] Chemische Berichte, 1900, vol. 33, p. 2505
[3] Bulletin de la Societe Chimique de France, 1900, vol. <3> 23, p. 838
[4] Chemische Berichte, 1900, vol. 33, p. 2505,2506

5-Chloro-2-nitrotoluene Preparation Products And Raw materials

Raw materials

Preparation Products

5-Chloroindole-3-carboxaldehyde 5-Chloroindole

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View Lastest Price from 5-Chloro-2-nitrotoluene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Chloro-2-nitrotoluene 5367-28-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-28

Career Henan Chemical Co

Product: 5-Chloro-2-nitrotoluene 5367-28-2
Price: US $6.00/KG
Min. Order: 2KG
Purity: 98%
Supply Ability: 1KG,50KG,100KG
Release date: 2019-09-03

5367-28-2, 5-Chloro-2-nitrotolueneRelated Search:

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5367-28-2

Building Blocks

Organic Building Blocks

Nitrogen Compounds

Nitro Compounds

Aromatic Hydrocarbons (substituted) & Derivatives

Nitro Compounds

Nitrogen Compounds

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