ChemicalBook > CAS DataBase List > WEHI-539
WEHI-539
- Product Name
- WEHI-539
- CAS No.
- 1431866-33-9
- Chemical Name
- WEHI-539
- Synonyms
- CS-1739;WEHI-539;WEHI539;WEHI 539;WEHI-539 ( CT-WE539);(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr;5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid;5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid;4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-;(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
- CBNumber
- CB22655422
- Molecular Formula
- C31H29N5O3S2
- Formula Weight
- 583.72
- MOL File
- 1431866-33-9.mol
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WEHI-539 Property
- Boiling point:
- 827.6±75.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 10.24±0.20(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21478
- Product name
- WEHI-539
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21478
- Product name
- WEHI-539
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $233
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21478
- Product name
- WEHI-539
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $412
- Updated
- 2024/03/01
TRC
- Product number
- W498725
- Product name
- WEHI539
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3935
- Product name
- WEHI-539
- Packaging
- 50mg
- Price
- $955
- Updated
- 2021/12/16
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WEHI-539 Chemical Properties,Usage,Production
Uses
WEHI 539 is a selective BCL-XL inhibitor.
Biological Activity
wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1].
target
BCL-XL
References
[1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.
WEHI-539 Preparation Products And Raw materials
Raw materials
Preparation Products
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WEHI-539 Suppliers
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