ChemicalBook > CAS DataBase List > WEHI-539

WEHI-539

Product Name
WEHI-539
CAS No.
1431866-33-9
Chemical Name
WEHI-539
Synonyms
CS-1739;WEHI-539;WEHI539;WEHI 539;WEHI-539 ( CT-WE539);(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr;5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid;4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-;(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
CBNumber
CB22655422
Molecular Formula
C31H29N5O3S2
Formula Weight
583.72
MOL File
1431866-33-9.mol
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WEHI-539 Property

Boiling point:
827.6±75.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
10.24±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21478
Product name
WEHI-539
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21478
Product name
WEHI-539
Purity
≥98%
Packaging
5mg
Price
$233
Updated
2024/03/01
Cayman Chemical
Product number
21478
Product name
WEHI-539
Purity
≥98%
Packaging
10mg
Price
$412
Updated
2024/03/01
TRC
Product number
W498725
Product name
WEHI539
Packaging
2.5mg
Price
$195
Updated
2021/12/16
ApexBio Technology
Product number
A3935
Product name
WEHI-539
Packaging
50mg
Price
$955
Updated
2021/12/16
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WEHI-539 Chemical Properties,Usage,Production

Uses

WEHI 539 is a selective BCL-XL inhibitor.

Biological Activity

wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1].

target

BCL-XL

References

[1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.

WEHI-539 Preparation Products And Raw materials

Raw materials

Preparation Products

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WEHI-539 Suppliers

China 56 United States 13 Global 69
Nanjing Chemlin Chemical Co., Ltd
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1431866-33-9, WEHI-539Related Search:

4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WEHI-345 WEHI-539 HCl WEHI-345 (analog)

  • WEHI-539
  • (E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
  • WEHI-539 ( CT-WE539)
  • 5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid
  • (E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr
  • CS-1739
  • WEHI539;WEHI 539
  • 4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-
  • 1431866-33-9
  • C31H29N5O3S2