AT-101

ChemicalBook > CAS DataBase List > AT-101

Product Name: AT-101
CAS No.: 866541-93-7
Chemical Name: AT-101
Synonyms: AT101 acetate;AT-101 (AT101);AT-101 USP/EP/BP;AT-101 (acetic acid);(-)-Gossypol acetic acid;(R)-(-)-Gossypol acetic acid, 10 mM in DMSO;Gossypol acetic acid Bcl-2 inhibitor AT101 AT-101;(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid));Bcl-2 Family,Autophagy,(R) ( ) Gossypol acetic acid,Inhibitor,(R)()Gossypol acetic acid,inhibit;(R)-1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetic acid salt
CBNumber: CB22658180
Molecular Formula: C32H34O10
Formula Weight: 578.60636
MOL File: 866541-93-7.mol

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AT-101 Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO : 39.33 mg/mL (67.97 mM)
form: Solid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0004767
Product name: [2,2'-BINAPHTHALENE]-8,8'-DICARBOXALDEHYDE, 1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-5,5'-BIS(1-METHYLETHYL)-, (2R)-, COMPD. WITH ACETIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.72
Updated: 2021/12/16

DC Chemicals

Product number: DC2015
Product name: AT-101(AT101)
Purity: >98%
Packaging: 250mg
Price: $800
Updated: 2021/12/16

DC Chemicals

Product number: DC2015
Product name: AT-101(AT101)
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

CSNpharm

Product number: CSN18501
Product name: AT-101AceticAcid
Packaging: 1mg
Price: $50
Updated: 2021/12/16

CSNpharm

Product number: CSN18501
Product name: AT-101AceticAcid
Packaging: 5mg
Price: $71
Updated: 2021/12/16

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AT-101 Chemical Properties,Usage,Production

Biological Activity

AT-101, the R-(-) enantiomer of Gossypol acetic acid, binds to Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.32 μM, 0.48 μM and 0.18 μM; no Inhibits the BIR3 domain and BID. Phase 2.

in vitro

AT-101 inhibits a diverse panel of lymphoproliferative malignancies with IC50 of 1.2 μM to 7.4 μM after 24 hours of treatment, 0.7 μM to 3.9 μM after 48 hours of treatment, IC50 of 72 hours after treatment 0.3 μM to 1.7 μM. AT-101 (10 μM) disrupts mitochondrial membrane potential (Δψm) in a concentration- and time-dependent manner in diffuse large B-cell and mantle cell lymphoma cell lines.

in vivo

AT-101 treated SCID beige mice bearing RL-DLBCL xenografts, it was still detectable in plasma, with a mean concentration of 0.49 μM in the 35 mg/kg group and 0.39 μM in the 200 mg/kg group . In SCID beige mice treated with it, peak plasma concentrations were observed after 30 minutes, and the mean plasma concentration in the 200 mg/kg group was almost 4-fold higher than that in the 35 mg/kg group (7.88 μM and 27.78 μM, respectively).

target

td>

Target	Value
Mcl-1 (Cell-free assay)	0.18 μM(Ki)
Bcl-2 (Cell-free assay)	0.32 μM(Ki)
Bcl-xL (Cell-free assay)	0.48 μM(Ki)

AT-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AT-101 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: AT-101 866541-93-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

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AT-101 [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. wi

AT-101 (acetic acid)

AT101 acetate

AT-101 (AT101)

AT-101 USP/EP/BP

(-)-Gossypol acetic acid

(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

Gossypol acetic acid Bcl-2 inhibitor AT101 AT-101

Bcl-2 Family,Autophagy,(R) ( ) Gossypol acetic acid,Inhibitor,(R)()Gossypol acetic acid,inhibit

(R)-1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetic acid salt

(R)-(-)-Gossypol acetic acid, 10 mM in DMSO

866541-93-7

Inhibitor

Inhibitors