3,5-Dimethoxyphenol Property

Melting point:

40-43 °C (lit.)

Boiling point:

172-175 °C/17 mmHg (lit.)

Density 

1.1690 (rough estimate)

refractive index 

1.4745 (estimate)

Flash point:

173 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

pK1:9.345 (25°C)

form 

Liquid

color 

Clear colorless to orange-red to pale pink-brownish

Water Solubility 

Soluble in methanol, ethanol, benzene, water (slightly), and chloroform.

Sensitive 

Air & Light Sensitive

BRN 

1239156

InChIKey

XQDNFAMOIPNVES-UHFFFAOYSA-N

LogP

1.640

CAS DataBase Reference

500-99-2(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 3,5-dimethoxy-(500-99-2)

EPA Substance Registry System

Phenol, 3,5-dimethoxy- (500-99-2)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

10

Hazard Note 

Irritant

HS Code 

29095090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3,5-Dimethoxyphenol Chemical Properties,Usage,Production

Chemical Properties

slightly pink to yellow crystalline powder

Uses

3,5-dimethoxyphenol is a marker for poisoning from Taxus baccata.

Uses

3,5-Dimethoxyphenol is a phenol derivative as antinitrosating agent.

Definition

ChEBI: 3,5-Dimethoxyphenol is a member of methoxybenzenes and a member of phenols.

Synthesis

Ethanethiol (1.25g, 1.5 ml, 0.02 mole) dissolved in N, N- dimethyl-formamide (20 ml) is added to a suspension of sodium hydride (1 g of 50%oil dispersion) in dry DMF (10 ml) under an atmosphere of nitrogen. The mixture is stirred for 5 min under anhydrous conditions. A solution of phloroglucinol trimethyl ether (1.14) (1 g,0.006 moles) in dry DMF (10 ml)is added, and the mixture is refluxed for 3 hr. The reaction mixture is cooled and acidified with hydrochloric acid (10%). It is extracted with ether(3 x 50 ml). The ether extract is washed with water and extracted with sodium hydroxide solution (5%). The clear alkaline extract is acidified with hydrochloric acid. The mixture is extracted with ether. The ether extract is washed with water, ried (anhydrous sodium sulphate), and drilled. 3,5-Dimethoxyphenol is obtained as an oil. Yield 0.9 g (98.1%).B.p.198-199°/30 mm.

Purification Methods

Purify the phenol by distillation followed by sublimation in a vacuum. [Beilstein 6 IV 7362.]