ChemicalBook > CAS DataBase List > Diallyl trisulfide

Diallyl trisulfide

Product Name: Diallyl trisulfide
CAS No.: 2050-87-5
Chemical Name: Diallyl trisulfide
Synonyms: FEMA 3265;Allitridin;ALLYLTRISULPHIDE;ALLYL TRISULFIDE;DIALLYL TRISULFIDE;DIALLYL TRISULPHIDE;3-diallyltrisulfane;1,3-Diallyltrisulfane;Diallyl pertrisulfide;Diallyl Trisulfide (AS)
CBNumber: CB2269270
Molecular Formula: C6H10S3
Formula Weight: 178.34
MOL File: 2050-87-5.mol

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Diallyl trisulfide Property

Boiling point:: bp6 92°; bp0.0008 66-67°
Density: 1.085
FEMA: 3265 | DIALLYL TRISULFIDE
refractive index: nD20 1.5896
storage temp.: -20°C
solubility: Soluble in acetone, Ethanol(~3 mg/ml), DMSO (~5 mg/ml), and DMF (~10 mg/ml).
form: oil
color: Colorless to light yellow
Odor: at 0.10 % in propylene glycol. garlic green onion metallic
Odor Type: sulfurous
biological source: Allium sativum L.
Water Solubility: insoluble in water.
JECFA Number: 587
InChI: InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InChIKey: UBAXRAHSPKWNCX-UHFFFAOYSA-N
SMILES: S(SCC=C)SCC=C
LogP: 4.59
CAS DataBase Reference: 2050-87-5(CAS DataBase Reference)
NIST Chemistry Reference: Trisulfide, di-2-propenyl(2050-87-5)

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Safety

RIDADR: 2810
WGK Germany: 3
RTECS: BC6168000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00577
Product name: Diallyl trisulfide
Purity: ≥97% (HPLC)
Packaging: 100mg
Price: $207
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00577
Product name: Diallyl trisulfide
Purity: ≥97% (HPLC)
Packaging: 500mg
Price: $577
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00289
Product name: Diallyl trisulfide
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $191
Updated: 2025/07/31

Cayman Chemical

Product number: 10012577
Product name: Diallyl Trisulfide
Purity: ≥95%
Packaging: 25mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 10012577
Product name: Diallyl Trisulfide
Purity: ≥95%
Packaging: 50mg
Price: $73
Updated: 2024/03/01

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Diallyl trisulfide Chemical Properties,Usage,Production

Description

Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor. It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM). DATS suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation. Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.

Chemical Properties

Diallyl trisulfide is a yellow liquid with a disagreeable odor. It is a stable transformation product of allicin. Insoluble in water and ethanol, miscible in ether. Natural products are found in onions, garlic, etc. Diallyl trisulfide (DATS) and diallyl disulfide (DADS) are the two major organosulfides in garlic oil.

Occurrence

Reported found in garlic oil.

Uses

Diallyl trisulfide (DATS) has been used to study its antimicrobial effects against Campylobacter jejuni. It has also been used to test its effect on hepatic regeneration in partial hepatectomy (PHx) rats.

Uses

Diallyl Trisulfide, is an organosulfur garlic compound that induces neovasculogenesis and has preventive effects against ischemic injuries. Antiarrythmic effect.

Preparation

In nature, diallyl trisulfide is formed from alliin and allicin.

Definition

ChEBI: Diallyl trisulfide is an organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity It has a role as an apoptosis inducer, an estrogen receptor antagonist, an antineoplastic agent, a vasodilator agent, an antioxidant, an anti-inflammatory agent, an insecticide, an antiprotozoal drug, a platelet aggregation inhibitor and an antilipemic drug.

General Description

Diallyl trisulfide (DATS) is one of the organosulfur compounds found in garlic (Allium sativum), and other Allium genera such as onions. This sulfur-rich compound is produced by the rapid disintegration of its metabolic precursor Allicin.

Biochem/physiol Actions

DATS is a potent anti-cancer and chemopreventive agent that regulates apoptosis, metastasis, cell cycle, and angiogenesis in cancer pathways. It is also an excellent neuroprotective agent. DATS elicits antioxidant and anti-inflammatory activities against doxorubicin (DOX)-induced rats brains. It may improve glycemic control, muscle glucose utilization, and insulin secretion in streptozotocin-induced diabetic rats.

References

[1] GLORIA A BENAVIDES. Hydrogen sulfide mediates the vasoactivity of garlic.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007: 17977-17982. DOI: 10.1073/pnas.0705710104
[2] DONG XIAO. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2[J]. Oncogene, 2004, 23 33: 5594-5606. DOI: 10.1038/sj.onc.1207747
[3] TAKASHI HOSONO. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin.[J]. The Journal of Biological Chemistry, 2005, 280 50: 41487-41493. DOI: 10.1074/jbc.m507127200
[4] DONG XIAO. Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction.[J]. Clinical Cancer Research, 2006, 12 22: 6836-6843. DOI: 10.1158/1078-0432.ccr-06-1273
[5] ZHE ZHOU. Microarray analysis of altered gene expression in diallyl trisulfide-treated HepG2 cells.[J]. Pharmacological Reports, 2005, 57 6: 818-823.
[6] GUPTA NISHA Porter T D. Garlic and Garlic-Derived Compounds Inhibit Human Squalene Monooxygenase[J]. Journal of Nutrition, 2001, 131 6: Pages 1662-1667. DOI: 10.1093/jn/131.6.1662

Diallyl trisulfide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diallyl trisulfide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Diallyl trisulfide 2050-87-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-12

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Diallyl Trisulfide 2050-87-5
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-28

Hebei Yanxi Chemical Co., Ltd.

Product: Diallyl trisulfide 2050-87-5
Price: US $50.00-35.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 25 tons
Release date: 2024-02-27

2050-87-5, Diallyl trisulfideRelated Search:

N,N-Dimethylallylamine 1,5-HEXADIENE Allyloxypolyethyleneglycol Diallylamine Diallyldisulfide Allyl ether Allyl glycidyl ether Allicin Allylthiourea Allyl chloride Methyl allyl trisulfide 2,3,4-TRITHIAHEXANE 3,4,5-TRITHIAHEPTANE Dimethyl trisulfide Bisphenol S diallyl ether Diallyl trisulfide DIALLYL TRISULFIDE(RG)

ALLYLTRISULPHIDE

1,1'-(Trithio)bis(2-propene)

Allitridin

Bis(2-propenyl) trisulfide

Diallyl pertrisulfide

PROP-2-ENYL-TRITHIO PROP-2-ENE

3-(allylthio)disulfanylprop-1-ene

3-prop-2-enylsulfanyldisulfanylprop-1-ene

1,3-Diallyltrisulfane

Trisulfide, di-2-propenyl

DIALLYL TRISULFIDE

DIALLYL TRISULPHIDE

FEMA 3265

ALLYL TRISULFIDE

3-diallyltrisulfane

Trisulfide, di-2-propen-1-yl

Diallyl trisulfide USP/EP/BP

Diallyl trisulfide, ≥98% (HPLC)

C6H10S3 Diallyl trisulfide 2050-87-5

Diallyl Trisulfide (AS)

Acetylcysteine Impurity 118

Diallyl Trisulfide, 10 mM in DMSO

2050-87-5

C3H52S3

C6H10S3

sulfide Flavor