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2',3'-O-Isopropylideneinosine

Product Name
2',3'-O-Isopropylideneinosine
CAS No.
2140-11-6
Chemical Name
2',3'-O-Isopropylideneinosine
Synonyms
2',3'-Ipr-Ino;-O-Isopropylideneinosine;2',3'-isopropylideneinosine;2',3'-ISOPROPYLIDENEINOSINE;2',3'-O-Isopropyrideneinosine;2',3'-0-lsopropylideneinosine;2‘,3'-O-lsopropylideneinosine;2',3'-O-Isopropylideneinosine;2',3'-O-Isopropylideneinosine;2'-O,3'-O-Isopropylideneinosine
CBNumber
CB2271080
Molecular Formula
C13H16N4O5
Formula Weight
308.29
MOL File
2140-11-6.mol
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2',3'-O-Isopropylideneinosine Property

Melting point:
263-272°C
Boiling point:
606.6±65.0 °C(Predicted)
Density 
1.80±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Solid
pka
14.14±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C13H16N4O5/c1-13(2)21-8-6(3-18)20-12(9(8)22-13)17-5-16-7-10(17)14-4-15-11(7)19/h4-6,8-9,12,18H,3H2,1-2H3,(H,14,15,19)/t6-,8-,9-,12-/m1/s1
InChIKey
LIEKLUBCIPVWQD-WOUKDFQISA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)[C@@H]2OC(O[C@H]12)(C)C
CAS DataBase Reference
2140-11-6(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S450715
Product name
2',3'-ISOPROPYLIDENEINOSINE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
S450715
Product name
2'',3''-ISOPROPYLIDENEINOSINE
Purity
AldrichCPR
Packaging
250MG
Price
$29.8
Updated
2024/03/01
TCI Chemical
Product number
I0704
Product name
2',3'-O-Isopropylideneinosine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$25
Updated
2025/07/31
TRC
Product number
I868500
Product name
2'',3''-O-Isopropylideneinosine
Packaging
50g
Price
$115
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0000565
Product name
2',3'-O-ISOPROPYLIDENEINOSINE
Purity
95.00%
Packaging
1G
Price
$117.6
Updated
2021/12/16
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2',3'-O-Isopropylideneinosine Chemical Properties,Usage,Production

Chemical Properties

2',3'-O-Isopropylideneinosine is White Solid

Uses

2',3'-O-Isopropylideneinosine is an inosine derivative as antiviral, bactericidal, and antitumor agent for immunopotentiating uses.

Uses

A useful precursor for the preparation of nucleic acids

Synthesis

58-63-9

77-76-9

2140-11-6

To a solution of inosine (0.998 g, 3.72 mmol) in dimethylformamide (DMF, 30 mL) was sequentially added 2,2-dimethoxypropane (1.8 mL, 14.59 mmol) and p-toluenesulfonic acid monohydrate (0.038 g, 0.372 mmol). The reaction mixture was stirred under argon (Ar) protection for 24 hours. Upon completion of the reaction, DMF was removed by evaporation under reduced pressure, followed by alkalinization of the reaction mixture with 3% ammonia solution and evaporation again to dryness. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 95/5, v/v) to afford the target compound 22 in white foamy form in 80% yield. The product was characterized by 1H-NMR (200 MHz, DMSO-d6): δ 1.34, 1.50 (6H, s, (CH3)2C), 3.6 (2H, t, CH2-5'), 4.37 (1H, m, H-4'), 4.94 (1H, m, H-3'), 5.18 (1H, t, OH-5'), 5.37 (1H, dd. J = 3.7 Hz, H-2'), 6.12 (1H, d, J = 2.4 Hz, H-1'), 8.05 (1H, s, H-2), 8.32 (1H, s, H-8), and 12.44 (1H, br s, NH-3).ESI-MS analysis showed: m/z 309.1 [M + H]+, molecular formula C13H16N4O5, molecular weight 308.29.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 202 - 209
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 5, p. 2087 - 2103
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5349 - 5370
[4] Heterocycles, 2013, vol. 87, # 11, p. 2369 - 2384
[5] Chinese Chemical Letters, 2011, vol. 22, # 12, p. 1439 - 1442

2',3'-O-Isopropylideneinosine Preparation Products And Raw materials

Raw materials

Preparation Products

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2',3'-O-Isopropylideneinosine Suppliers

Americas 1 Canada 1 China 127 Europe 1 Germany 2 India 3 Japan 1 Russia 1 Switzerland 1 United Kingdom 6 United States 16 Global 160
Hangzhou Measure Life Technology Co.,LTD
Tel
13782581061
Email
2250804796@qq.com
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China
ProdList
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
ProdList
40228
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
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44801
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
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57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
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View Lastest Price from 2',3'-O-Isopropylideneinosine manufacturers

Honest Joy Holdings Limited
Product
2',3'-O-Isopropylideneinosine
Price
US $0.00/KG
Min. Order
1KG
Purity
97.3%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
2',3'-O-Isopropylideneinosine 2140-11-6
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-15

2140-11-6, 2',3'-O-IsopropylideneinosineRelated Search:

Mesityl oxide Disodium 5'-Inosinate Isoprinosine Dideoxyinosine 6-Hydroxypurine 3-Isopropoxypropylamine 2'-Deoxyinosine 1-METHYL-1H-IMIDAZOLE-4-CARBALDEHYDE (1-Methyl-1H-imidazol-4-yl)methylamine (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol AICAR 2',3'-O-Isopropylideneguanosine Inosine 1,3-Dioxolane-4-methanol 2,2-Dimethyl-1,3-dioxolane-4-methanol [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanamine 2',3'-O-ISOPROPYLIDENE-5'-TRITYLINOSINE 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE

  • 2',3'-isopropylideneinosine
  • 2',3'-O-Isopropylidene-D-inosine
  • 2'',3''-O-ISOPROPYLIDENEINOSINE,98.0+%(LC)
  • 2',3'-O-(1-Methylethylidene)- Inosine
  • 9-(2,3-O-Isopropylidene-beta-D-ribofuranosyl)hypoxanthine
  • 2'-O,3'-O-Isopropylidene-2-deaminoguanosine
  • 2'-O,3'-O-Isopropylidene-6-hydroxy-6-deaminoadenosine
  • 2'-O,3'-O-Isopropylideneinosine
  • 2',3'-O-Isopropylideneinosine≥ 98% (HPLC)
  • 9-((3aR,4R,6R,6aR)-6-(HydroxyMethyl)-2,2-diMethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ol
  • -O-Isopropylideneinosine
  • 2',3'-O-Isopropylideneinosine&gt
  • Inosine, 2',3'-O-(1-methylethylidene)-
  • 2',3'-Ipr-Ino
  • 2',3'-O-Isopropylideneinosine USP/EP/BP
  • 2',3'-O-Isopropyrideneinosine
  • 2',3'-0-lsopropylideneinosine
  • 2‘,3'-O-lsopropylideneinosine
  • 2',3'-O-Isopropylideneinosine
  • 2',3'-ISOPROPYLIDENEINOSINE
  • 2′,3′-O-Isopropylideneinosine, CAS 2140-11-6
  • 2',3'-O-Isopropylideneinosine
  • 2140-11-6
  • 2140-11-06
  • 40-11-6
  • Heterocycles
  • Biochemistry
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Bases & Related Reagents
  • Nucleotides