HTH-01-015

ChemicalBook > CAS DataBase List > HTH-01-015

Product Name: HTH-01-015
CAS No.: 1613724-42-7
Chemical Name: HTH-01-015
Synonyms: CS-2296;HTH-01-015;HTH-01-015 >=98% (HPLC);HTH-01-015, 10 mM in DMSO;CHSDJDLAKKAWCI-UHFFFAOYSA-N;inhibit,AMPK,AMP-activated protein kinase,HTH 01 015,HTH01015,Inhibitor;5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one;4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one;6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-
CBNumber: CB22715641
Molecular Formula: C26H28N8O
Formula Weight: 468.55
MOL File: 1613724-42-7.mol

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HTH-01-015 Property

Boiling point:: 759.6±70.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≥23.45 mg/mL in DMSO; insoluble in H2O; ≥14.67 mg/mL in EtOH with ultrasonic
form: powder
pka: 9.84±0.10(Predicted)
color: white to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1446
Product name: HTH-01-015
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1446
Product name: HTH-01-015
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $520
Updated: 2024/03/01

Cayman Chemical

Product number: 19091
Product name: HTH-01-015
Purity: ≥95%
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 19091
Product name: HTH-01-015
Purity: ≥95%
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 19091
Product name: HTH-01-015
Purity: ≥95%
Packaging: 10mg
Price: $201
Updated: 2024/03/01

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HTH-01-015 Chemical Properties,Usage,Production

Description

NUAK1 (also known as AMPK-related kinase 5) and NUAK2 (also known as SNF1/AMPK-related kinase) are members of the AMP-activated protein kinase (AMPK) family of protein kinases that are activated by the liver kinase B1 tumor suppressor kinase. NUAK kinases are thought to have roles in regulating cell adhesion, cancer cell invasion, embryonic development, senescence, proliferation, neuronal polarity, and axon branching. HTH-01-015 is a selective inhibitor of NUAK1 (IC₅₀ = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. At 10 μM, HTH-01-015 has been shown to partially inhibit the phosphorylation of the NUAK1 substrate, myosin phosphate-targeting subunit 1 at Ser⁴⁴⁵. When administered to mouse embryonic fibroblasts in vitro, 10 μM HTH-01-015 inhibits proliferation and migration in a wound-healing assay. It has also been shown to impair the invasive potential of U2OS cells at similar concentrations in a 3D cell invasion assay.

Uses

HTH 01-015 is a highly specific protein kinase inhibitor of NUAK1. It inhibits the NUAK1 phosphorylation of myosin phosphate-targeting subunit 1 (MYPT1) substrate.

Biochem/physiol Actions

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase, a member of the AMPK family that are that are activated by the LKB1 (liver kinaseB1) tumour suppressor kinase and involved in development and proliferation. HTH-01-015 has an IC50 of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with HTH-01-015 was found to suppress proliferation, restricting cells from entering into mitosis.

storage

Store at -20°C

References

1. sourav b, sara j b, hai-tsang h, et al. characterization of wz4003 and hth-01-015 as selective inhibitors of the lkb1-tumour-suppressor-activated nuak kinases. biochemical journal, 2014, 457(1): 215-225.

HTH-01-015 Preparation Products And Raw materials

Raw materials

Preparation Products

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HTH-01-015 Suppliers

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1613724-42-7, HTH-01-015Related Search:

HA-15 UNC0321 CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride CEP-18770 LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 GDC-0879 4-iodo-3-nitrobenzamide VBY-825

HTH-01-015

5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one

CS-2296

CHSDJDLAKKAWCI-UHFFFAOYSA-N

6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-

HTH-01-015 >=98% (HPLC)

inhibit,AMPK,AMP-activated protein kinase,HTH 01 015,HTH01015,Inhibitor

4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one

HTH-01-015, 10 mM in DMSO

1613724-42-7

Inhibitors