ChemicalBook > CAS DataBase List > AZ191

AZ191

Product Name: AZ191
CAS No.: 1594092-37-1
Chemical Name: AZ191
Synonyms: AZ191;CS-1824;AZ191 ，S7338;AZ-191;AZ 191;AZ191, 10 mM in DMSO;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine;2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-;[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine;Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191
CBNumber: CB22716123
Molecular Formula: C24H27N7O
Formula Weight: 429.52
MOL File: 1594092-37-1.mol

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AZ191 Property

Boiling point:: 705.3±70.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 7.76±0.42(Predicted)
color: white to yellow to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H301Toxic if swalloed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17693
Product name: AZ191
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17693
Product name: AZ191
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17693
Product name: AZ191
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 17693
Product name: AZ191
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Tocris

Product number: 5232
Product name: AZ191
Purity: ≥98%(HPLC)
Packaging: 10
Price: $199
Updated: 2021/12/16

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AZ191 Chemical Properties,Usage,Production

Uses

AZ191 is a potent and selective DYRK1B inhibitor (1).

Enzyme inhibitor

This potent and selective DYRK inhibitor (FW = 429.53 g/mol), also systematically named N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, selectively targets DYRK1B, a Dual specificity tyrosine-phosphorylation-regulated kinase, with an IC50 value of 17 nM, or about 5x and 110x higher affinity than for DYRK1A and DYRK2. AZ191 is effective both in vitro and in cells. DYRK1B has also been proposed to promote the turnover of Cyclin D1, a key regulator of mammalian G1-S-phase transitions. Cyclin D1 is phosphorylated on Thr-286 by GSK3β (or glycogen synthase kinase 3β), thereby promoting its degradation.

IC 50

DYRK1B

storage

Store at -20°C

AZ191 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ191 Suppliers

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View Lastest Price from AZ191 manufacturers

Career Henan Chemical Co

Product: AZ191 1594092-37-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

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AZ-191;AZ 191

CS-1824

N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine

N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191

[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine

AZ191

2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-

Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK

AZ191, 10 mM in DMSO

AZ191 ，S7338

1594092-37-1

C24H27N7O

Inhibitors