Citarinostat

ChemicalBook > CAS DataBase List > Citarinostat

Product Name: Citarinostat
CAS No.: 1316215-12-9
Chemical Name: Citarinostat
Synonyms: CS-1760;HDAC-IN-2;Citarinostat;ACY-241(CITARINOSTAT);Citarinostat (ACY-241);Citarinostat(ACY-241,HDAC-IN-2);ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT.;2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-;2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide
CBNumber: CB22723105
Molecular Formula: C24H26ClN5O3
Formula Weight: 467.95
MOL File: 1316215-12-9.mol

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Citarinostat Property

Density: 1.293±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥23.4 mg/mL in DMSO; insoluble in H2O; ≥4.87 mg/mL in EtOH with ultrasonic
form: solid
pka: 9.47±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26173
Product name: ACY-241
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 26173
Product name: ACY-241
Packaging: 25mg
Price: $315
Updated: 2024/03/01

Cayman Chemical

Product number: 26173
Product name: ACY-241
Packaging: 10mg
Price: $152
Updated: 2024/03/01

TRC

Product number: C585595
Product name: Citarinostat
Packaging: 25mg
Price: $305
Updated: 2021/12/16

AK Scientific

Product number: X3978
Product name: HDAC-IN-2
Packaging: 25mg
Price: $266
Updated: 2021/12/16

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Citarinostat Chemical Properties,Usage,Production

Description

ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6; IC₅₀ = 2.6 nM). It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC₅₀s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC₅₀ = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells when used at a concentration of 3 μM and completely inhibits it and induces apoptosis at a concentration of 10 μM. ACY-241, when used in combination with paclitaxel , inhibits proliferation in MiaPaCa-2, TOV-21G, and T47D cells. It also reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at a dose of 50 mg/kg in combination with paclitaxel. ACY-241, in combination with the somatostatin receptor agonist pasireotide , reduces hepatorenal cystogenesis in a rat model of polycystic liver disease.

Uses

Citarinostat is a HDAC inhibitor.

References

[1]. quayle sn, almeciga-pinto i, tamang d, et al. selective hdac inhibition by ricolinostat (acy-1215) or acy-241 synergizes with imid® immunomodulatory drugs in multiple myeloma (mm) and mantle cell lymphoma (mcl) cells. in: proceedings of the 106th annual meeting of the american association for cancer research, 2015, philadelphia, pa. philadelphia (pa): aacr; cancer res 2015;75(15 suppl):abstract nr 5380.
[2]. huang p, almeciga-pinto i, jordan m, et al. selective hdac inhibition by acy-241 enhances the activity of paclitaxel in solid tumor models. in: proceedings of the 2015 aacr-nci-eortc international conference on molecular targets and cancer therapeutics; 2015 nov 5-9; boston, massachusetts. philadelphia (pa): aacr

Citarinostat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Citarinostat manufacturers

Career Henan Chemical Co

Product: Citarinostat 1316215-12-9
Price: US $1.00/KG
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg /ton
Release date: 2019-12-20

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2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide

Citarinostat

Citarinostat (ACY-241)

ACY-241(CITARINOSTAT)

2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide

5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-

HDAC-IN-2

Citarinostat(ACY-241,HDAC-IN-2)

(Z)-2-((2-chlorophenyl)(phenyl)amino)-N-((Z)-7-hydroxy-7-(hydroxyimino)heptyl)pyrimidine-5-carbimidic acid

(Z)-2-((2-CHLOROPHENYL)(PHENYL)AMINO)-N-((Z)-7-HYDROXY-7-(HYDROXYIMINO)HEPTYL)PYRIMIDINE-5-CARBIMIDIC ACID;HDAC-IN-2

CS-1760

ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT.

N-(6-(hydroxycarbamoyl)hexyl)-2-(N-(2-chlorophenyl)-N-phenylamino)pyrimidine-5-carboxamide

1316215-12-9