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K-Ras(G12C) inhibitor 6

Product Name
K-Ras(G12C) inhibitor 6
CAS No.
2060530-16-5
Chemical Name
K-Ras(G12C) inhibitor 6
Synonyms
CS-2013;MDK30165;K-Ras(G12C) inhibitor 6;K-Ras(G12C) inhibitor 6 USP/EP/BP;N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide;Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-;N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide;Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6
CBNumber
CB22728650
Molecular Formula
C17H22Cl2N2O3S
Formula Weight
405.34
MOL File
2060530-16-5.mol
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K-Ras(G12C) inhibitor 6 Property

Boiling point:
643.4±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO
form 
solid
pka
10.21±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D438295
Product name
N-​[1-​[2-​(2,​4-Dichlorophenoxy)​acetyl]​-​4-​piperidinyl]​-​4-​mercapto-butanamide
Packaging
10mg
Price
$470
Updated
2021/12/16
ApexBio Technology
Product number
B3694
Product name
K-Ras(G12C)inhibitor6
Packaging
10mM(in 1mL DMSO)
Price
$130
Updated
2021/12/16
ApexBio Technology
Product number
B3694
Product name
K-Ras(G12C)inhibitor6
Packaging
10mg
Price
$200
Updated
2021/12/16
ApexBio Technology
Product number
B3694
Product name
K-Ras(G12C)inhibitor6
Packaging
25mg
Price
$420
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181272
Product name
K-Ras(G12C) inhibitor 6
Purity
>98%
Packaging
100mg
Price
$765
Updated
2021/12/16
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K-Ras(G12C) inhibitor 6 Chemical Properties,Usage,Production

Uses

N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide is an irreversible and allosteric inhibitor of the K-Ras(G12C) mutant. This compound has potential therapeutic application for diseases related to Ras signaling.

Biological Activity

k-ras (g12c) inhibitor 6 is an allosterical inhibitor of oncogenic mutation k-ras g12c [1].k-ras (g12c) inhibitor 6 is a cysteine-reactive small molecule. it irreversibly binds to the g12c mutantion of gtpase k-ras but not the wild-type k-ras with the relative potency value of 4.2. the binding pocket of k-ras for k-ras (g12c) inhibitor 6 is a new allosteric pocket, s-iip. binding of this pocket results in a change of the relative nucleotide affinity of ras to favour gdp over gtp, leading to an accumulation of inactive ras. since the mutation of k-ras is quite common in human cancers, the inhibitor of k-ras g12c should exert suppression activities in tumor cells. it has been reported that, some of the k-ras g12c inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines [1].

References

[1] ostrem j m, peters u, sos m l, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions. nature, 2013, 503(7477): 548-551.

K-Ras(G12C) inhibitor 6 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from K-Ras(G12C) inhibitor 6 manufacturers

Career Henan Chemical Co
Product
K-Ras(G12C) inhibitor 6 2060530-16-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

2060530-16-5, K-Ras(G12C) inhibitor 6Related Search:

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  • K-Ras(G12C) inhibitor 6
  • N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide
  • CS-2013
  • MDK30165
  • Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-
  • K-Ras(G12C) inhibitor 6 USP/EP/BP
  • N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide
  • Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6
  • 2060530-16-5
  • Inhibitors
  • API