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K-Ras inhibitor

Product Name
K-Ras inhibitor
CAS No.
1469338-01-9
Chemical Name
K-Ras inhibitor
Synonyms
6H05;CS-1817;K-Ras inhibitor;6H05/K-Ras inhibitor;6H05 trifluoroacetate;K-Ras inhibitor USP/EP/BP;6H05 trifluoroacetate 1469338-01-9(free base);1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide;4-Piperidinecarboxamide, 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-;1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide,2,2,2-trifluoroacetate (1:1)
CBNumber
CB92729348
Molecular Formula
C20H30ClN3O2S3
Formula Weight
476.12
MOL File
1469338-01-9.mol
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K-Ras inhibitor Property

Boiling point:
669.3±55.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥29.5 mg/mL in DMSO; ≥14.3 mg/mL in H2O; ≥24.15 mg/mL in EtOH
form 
solid
pka
15.05±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A8902
Product name
6H05
Packaging
5mg
Price
$140
Updated
2021/12/16
Crysdot
Product number
CD31003405
Product name
6H05
Purity
98+%
Packaging
5mg
Price
$360
Updated
2021/12/16
DC Chemicals
Product number
DC7736
Product name
6H05
Purity
>98%
Packaging
100mg
Price
$500
Updated
2021/12/16
DC Chemicals
Product number
DC7736
Product name
6H05
Purity
>98%
Packaging
250mg
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
DC7736
Product name
6H05
Purity
>98%
Packaging
1g
Price
$1800
Updated
2021/12/16
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K-Ras inhibitor Chemical Properties,Usage,Production

Biological Activity

6h05 is a selective inhibitorof the common oncogenic mutant k-ras (g12c). 6h05 allosterically modifies and inhibits the oncogenic g12c mutant of highly homologous protein h-ras, not affecting the wild-type k-ras [1].k-ras plays an important role in human cancer, cause mutations in k-ras are the most common activating lesions in human cancer[2]. 6h05 modifies the gdp-bound k-ras (g12c) the most, which can be and be applied as the starting point for drug-discovery efforts targeting k-ras (g12c) and eventually other alleles of k-ras. 6h05 can be used as an intermediate for the synthesis of oncogenic k-ras (g12c) inhibitors [3, 4].although it’s necessary to perform continued chemical optimization of 6h05 to be assessed in vivo, preliminary evaluation of 6h05 in lung cancer cell lines suggests that 6h05 shows allele-specific impairment of k-ras function[1]. there are questions still need to be illustrated that the selectivity and efficiency of 6h05 in vivo, as well as its effects on the subcellular localization of other farnesylated gtpases should be assessed further[1, 3].questions still need to be answered surrounding the in vivo selectivity and efficacy of 6h05, including its effects on the subcellular localization of other farnesylated gtpases [3].

References

[1] ostrem jm, peters u, sos ml, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions[j]. nature, 2013, 503(7477): 548-551.
[2] mccormick f. kras as a therapeutic target[j]. clinical cancer research, 2015, 21(8): 1797-1801.
[3] milroy l-g,ottmann c. the renaissance of ras[j]. acs chemical biology, 2014, 9(11): 2447-2458.
[4] lu sy, li s,zhang j. harnessing allostery: a novel approach to drug discovery[j]. medicinal research reviews, 2014, 34(6): 1242-1285.

K-Ras inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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K-Ras inhibitor Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
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China
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2923
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Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
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61
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
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Shanghai Qinghang Chemical Co. Ltd.
Tel
021-50840321, 18601625411
Fax
021-50840321
Email
thomasleehz@hotmail.com
Country
China
ProdList
216
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LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
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China
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2384
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4153
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YouCoChem (Beijing) Chemical Technology Co., Ltd.
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18800159827
Email
youcochem@163.com
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China
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D&C Chemicals
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+86-21-58447131
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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China
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1469338-01-9, K-Ras inhibitorRelated Search:


  • 1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide
  • 6H05 trifluoroacetate
  • K-Ras inhibitor
  • 6H05/K-Ras inhibitor
  • 6H05
  • CS-1817
  • 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide,2,2,2-trifluoroacetate (1:1)
  • 6H05 trifluoroacetate 1469338-01-9(free base)
  • 4-Piperidinecarboxamide, 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-
  • K-Ras inhibitor USP/EP/BP
  • 1469338-01-9
  • C20H30ClN3O2S3
  • C22H31ClF3N3O4S3
  • C20H30ClN3O2S3CF3COOH
  • Inhibitors