K-Ras(G12C) inhibitor 6
- Product Name
- K-Ras(G12C) inhibitor 6
- CAS No.
- 2060530-16-5
- Chemical Name
- K-Ras(G12C) inhibitor 6
- Synonyms
- CS-2013;MDK30165;K-Ras(G12C) inhibitor 6;K-Ras(G12C) inhibitor 6 USP/EP/BP;N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide;Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-;N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide;Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6
- CBNumber
- CB22728650
- Molecular Formula
- C17H22Cl2N2O3S
- Formula Weight
- 405.34
- MOL File
- 2060530-16-5.mol
K-Ras(G12C) inhibitor 6 Property
- Boiling point:
- 643.4±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO
- form
- solid
- pka
- 10.21±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- D438295
- Product name
- N-[1-[2-(2,4-Dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-butanamide
- Packaging
- 10mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- orb181272
- Product name
- K-Ras(G12C) inhibitor 6
- Purity
- >98%
- Packaging
- 100mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- orb181272
- Product name
- K-Ras(G12C) inhibitor 6
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1431.4
- Updated
- 2021/12/16
- Product number
- orb181272
- Product name
- K-Ras(G12C) inhibitor 6
- Purity
- >98%
- Packaging
- 1000mg
- Price
- $2691.1
- Updated
- 2021/12/16
- Product number
- B3694
- Product name
- K-Ras(G12C)inhibitor6
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $130
- Updated
- 2021/12/16
K-Ras(G12C) inhibitor 6 Chemical Properties,Usage,Production
Uses
N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide is an irreversible and allosteric inhibitor of the K-Ras(G12C) mutant. This compound has potential therapeutic application for diseases related to Ras signaling.
Biological Activity
k-ras (g12c) inhibitor 6 is an allosterical inhibitor of oncogenic mutation k-ras g12c [1].k-ras (g12c) inhibitor 6 is a cysteine-reactive small molecule. it irreversibly binds to the g12c mutantion of gtpase k-ras but not the wild-type k-ras with the relative potency value of 4.2. the binding pocket of k-ras for k-ras (g12c) inhibitor 6 is a new allosteric pocket, s-iip. binding of this pocket results in a change of the relative nucleotide affinity of ras to favour gdp over gtp, leading to an accumulation of inactive ras. since the mutation of k-ras is quite common in human cancers, the inhibitor of k-ras g12c should exert suppression activities in tumor cells. it has been reported that, some of the k-ras g12c inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines [1].
References
[1] ostrem j m, peters u, sos m l, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions. nature, 2013, 503(7477): 548-551.
K-Ras(G12C) inhibitor 6 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from K-Ras(G12C) inhibitor 6 manufacturers
- Product
- K-Ras(G12C) inhibitor 6 2060530-16-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25