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K-Ras(G12C) inhibitor 9

Product Name
K-Ras(G12C) inhibitor 9
CAS No.
1469337-91-4
Chemical Name
K-Ras(G12C) inhibitor 9
Synonyms
K-RAS inhibitor 9;K-Ras(G12C) inhibitor 9;K-Ras(GI2C) Inhibitor 9;K-Ras(G12C) inhibitor 9 USP/EP/BP;K RAS INHIBITOR-9; KRAS INHIBITOR 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide;Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-;K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9
CBNumber
CB32722367
Molecular Formula
C16H21ClIN3O4S
Formula Weight
513.78
MOL File
1469337-91-4.mol
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K-Ras(G12C) inhibitor 9 Property

Boiling point:
656.3±65.0 °C(Predicted)
Density 
1.68±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
9.68±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18005
Product name
K-Ras(G12C) Inhibitor 9
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18005
Product name
K-Ras(G12C) Inhibitor 9
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18005
Product name
K-Ras(G12C) Inhibitor 9
Purity
≥98%
Packaging
10mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
18005
Product name
K-Ras(G12C) Inhibitor 9
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
C367445
Product name
N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide
Packaging
5mg
Price
$185
Updated
2021/12/16
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K-Ras(G12C) inhibitor 9 Chemical Properties,Usage,Production

Description

K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.

Uses

N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide is an allosteric inhibitor of tumor-promoting K-Ras(G12c).

in vitro

k-ras(g12c) inhibitor 9 belongs to a series of small molecules, which irreversibly compete with gtp and gdp for binding to a common oncogenic k-ras(g12c) mutant and blocked the association of b-raf and c-raf with k-ras(g12c). k-ras(g12c) inhibitor 9 (10 μm) decreased viability and increased apoptosis of g12c mutations-containing lung cancer cell lines (h1792, calu-1, h358, and h23) [1].

target

k-ras(g12c)

References

1. ostrem jm, peters u, sos ml, wells ja, shokat km. k-ras(g12c) inhibitors allosterically control gtp affinity and effector interactions. nature. 2013;503(7477):548-51. 2. hunter jc, gurbani d, ficarro sb, carrasco ma, lim sm, choi hg, et al. in situ selectivity profiling and crystal structure of sml-8-73-1, an active site inhibitor of oncogenic k-ras g12c. proc natl acad sci u s a. 2014;111(24):8895-900. 3. lim sm, westover kd, ficarro sb, harrison ra, choi hg, pacold me, et al. therapeutic targeting of oncogenic k-ras by a covalent catalytic site inhibitor. angew chem int ed engl. 2014;53(1):199-204.

K-Ras(G12C) inhibitor 9 Preparation Products And Raw materials

Raw materials

Preparation Products

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K-Ras(G12C) inhibitor 9 Suppliers

AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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United States
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ShangHai KenEn Chemical Technology Co., Ltd.
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13120367189
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021-50315529
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China
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Target molecule Corp.
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1469337-91-4, K-Ras(G12C) inhibitor 9Related Search:


  • K-Ras(G12C) inhibitor 9
  • N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide
  • K RAS INHIBITOR-9; KRAS INHIBITOR 9
  • K-RAS inhibitor 9
  • Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-
  • K-Ras(G12C) inhibitor 9 USP/EP/BP
  • K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9
  • K-Ras(GI2C) Inhibitor 9
  • 1469337-91-4
  • C16H21ClIN3O4S
  • Inhibitors