K-Ras(G12C) inhibitor 9
- Product Name
- K-Ras(G12C) inhibitor 9
- CAS No.
- 1469337-91-4
- Chemical Name
- K-Ras(G12C) inhibitor 9
- Synonyms
- K-RAS inhibitor 9;K-Ras(G12C) inhibitor 9;K-Ras(GI2C) Inhibitor 9;K-Ras(G12C) inhibitor 9 USP/EP/BP;K RAS INHIBITOR-9; KRAS INHIBITOR 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide;Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-;K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9
- CBNumber
- CB32722367
- Molecular Formula
- C16H21ClIN3O4S
- Formula Weight
- 513.78
- MOL File
- 1469337-91-4.mol
K-Ras(G12C) inhibitor 9 Property
- Boiling point:
- 656.3±65.0 °C(Predicted)
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 9.68±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18005
- Product name
- K-Ras(G12C) Inhibitor 9
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18005
- Product name
- K-Ras(G12C) Inhibitor 9
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 18005
- Product name
- K-Ras(G12C) Inhibitor 9
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 18005
- Product name
- K-Ras(G12C) Inhibitor 9
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- C367445
- Product name
- N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
K-Ras(G12C) inhibitor 9 Chemical Properties,Usage,Production
Description
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.
Uses
N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide is an allosteric inhibitor of tumor-promoting K-Ras(G12c).
in vitro
k-ras(g12c) inhibitor 9 belongs to a series of small molecules, which irreversibly compete with gtp and gdp for binding to a common oncogenic k-ras(g12c) mutant and blocked the association of b-raf and c-raf with k-ras(g12c). k-ras(g12c) inhibitor 9 (10 μm) decreased viability and increased apoptosis of g12c mutations-containing lung cancer cell lines (h1792, calu-1, h358, and h23) [1].
target
k-ras(g12c)
References
1. ostrem jm, peters u, sos ml, wells ja, shokat km. k-ras(g12c) inhibitors allosterically control gtp affinity and effector interactions. nature. 2013;503(7477):548-51. 2. hunter jc, gurbani d, ficarro sb, carrasco ma, lim sm, choi hg, et al. in situ selectivity profiling and crystal structure of sml-8-73-1, an active site inhibitor of oncogenic k-ras g12c. proc natl acad sci u s a. 2014;111(24):8895-900. 3. lim sm, westover kd, ficarro sb, harrison ra, choi hg, pacold me, et al. therapeutic targeting of oncogenic k-ras by a covalent catalytic site inhibitor. angew chem int ed engl. 2014;53(1):199-204.
K-Ras(G12C) inhibitor 9 Preparation Products And Raw materials
Raw materials
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