K-Ras inhibitor

ChemicalBook > CAS DataBase List > K-Ras inhibitor

Product Name: K-Ras inhibitor
CAS No.: 1469338-01-9
Chemical Name: K-Ras inhibitor
Synonyms: 6H05;CS-1817;K-Ras inhibitor;6H05/K-Ras inhibitor;6H05 trifluoroacetate;K-Ras inhibitor USP/EP/BP;6H05 trifluoroacetate 1469338-01-9(free base);1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide;4-Piperidinecarboxamide, 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-;1-{2-[(4-chlorophenyl)sulfanyl]acetyl}-N-(2-{[2-(dimethylamino)ethyl]disulfanyl}ethyl)piperidine-4-carboxamide
CBNumber: CB92729348
Molecular Formula: C20H30ClN3O2S3
Formula Weight: 476.12
MOL File: 1469338-01-9.mol

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K-Ras inhibitor Property

Boiling point:: 669.3±55.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥29.5 mg/mL in DMSO; ≥14.3 mg/mL in H2O; ≥24.15 mg/mL in EtOH
form: solid
pka: 15.05±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A8902
Product name: 6H05
Packaging: 5mg
Price: $140
Updated: 2021/12/16

Crysdot

Product number: CD31003405
Product name: 6H05
Purity: 98+%
Packaging: 5mg
Price: $360
Updated: 2021/12/16

DC Chemicals

Product number: DC7736
Product name: 6H05
Purity: >98%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

DC Chemicals

Product number: DC7736
Product name: 6H05
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC7736
Product name: 6H05
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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K-Ras inhibitor Chemical Properties,Usage,Production

Biological Activity

6h05 is a selective inhibitorof the common oncogenic mutant k-ras (g12c). 6h05 allosterically modifies and inhibits the oncogenic g12c mutant of highly homologous protein h-ras, not affecting the wild-type k-ras [1].k-ras plays an important role in human cancer, cause mutations in k-ras are the most common activating lesions in human cancer[2]. 6h05 modifies the gdp-bound k-ras (g12c) the most, which can be and be applied as the starting point for drug-discovery efforts targeting k-ras (g12c) and eventually other alleles of k-ras. 6h05 can be used as an intermediate for the synthesis of oncogenic k-ras (g12c) inhibitors [3, 4].although it’s necessary to perform continued chemical optimization of 6h05 to be assessed in vivo, preliminary evaluation of 6h05 in lung cancer cell lines suggests that 6h05 shows allele-specific impairment of k-ras function[1]. there are questions still need to be illustrated that the selectivity and efficiency of 6h05 in vivo, as well as its effects on the subcellular localization of other farnesylated gtpases should be assessed further[1, 3].questions still need to be answered surrounding the in vivo selectivity and efficacy of 6h05, including its effects on the subcellular localization of other farnesylated gtpases [3].

References

[1] ostrem jm, peters u, sos ml, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions[j]. nature, 2013, 503(7477): 548-551.
[2] mccormick f. kras as a therapeutic target[j]. clinical cancer research, 2015, 21(8): 1797-1801.
[3] milroy l-g,ottmann c. the renaissance of ras[j]. acs chemical biology, 2014, 9(11): 2447-2458.
[4] lu sy, li s,zhang j. harnessing allostery: a novel approach to drug discovery[j]. medicinal research reviews, 2014, 34(6): 1242-1285.

K-Ras inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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1469338-01-9, K-Ras inhibitorRelated Search:

K-Ras(G12C) inhibitor 9 LB 42708 K-Ras(G12C) inhibitor 6 1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one Momelotinib Fedratinib

1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide

6H05 trifluoroacetate

K-Ras inhibitor

6H05/K-Ras inhibitor

6H05

CS-1817

1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide,2,2,2-trifluoroacetate (1:1)

6H05 trifluoroacetate 1469338-01-9(free base)

4-Piperidinecarboxamide, 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-

K-Ras inhibitor USP/EP/BP

1-{2-[(4-chlorophenyl)sulfanyl]acetyl}-N-(2-{[2-(dimethylamino)ethyl]disulfanyl}ethyl)piperidine-4-carboxamide

1469338-01-9

C20H30ClN3O2S3

C22H31ClF3N3O4S3

C20H30ClN3O2S3CF3COOH

Inhibitors