(S)-1-(2-FLUOROPHENYL)ETHANOL
- Product Name
- (S)-1-(2-FLUOROPHENYL)ETHANOL
- CAS No.
- 171032-87-4
- Chemical Name
- (S)-1-(2-FLUOROPHENYL)ETHANOL
- Synonyms
- S-OF-PEL;(S)-1-(2-FLUOROPHENYL)ETHANOL;(S)-2'-Fluorophenylethan-1-ol;(S)-1-(o-Fluorophenyl)ethanol;(S)-1-(2-Ffluorophenyl)ethanol;(1S)-1-(2-Fluorophenyl)ethanol;(1S)-1-(2-Fluorophenyl)ethan-1-ol;(S)-2-Fluoro-alpha-methylbenzyl alcohol;Benzenemethanol,2-fluoro-a-methyl-, (aS)-;Benzenemethanol, 2-fluoro-α-methyl-, (αS)-
- CBNumber
- CB2274384
- Molecular Formula
- C8H9FO
- Formula Weight
- 140.15
- MOL File
- 171032-87-4.mol
(S)-1-(2-FLUOROPHENYL)ETHANOL Property
- Boiling point:
- 193℃
- Density
- 1.123
- Flash point:
- 88℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.95±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F593623
- Product name
- (S)-1-(2-Fluorophenyl)ethanol
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- F593623
- Product name
- (S)-1-(2-Fluorophenyl)ethanol
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- PC0605
- Product name
- (1S)-1-(2-Fluorophenyl)ethan-1-ol
- Packaging
- 1g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- 2602-3-S2
- Product name
- (S)-1-(2-Fluorophenyl)ethanol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- HCH0014718
- Product name
- (S)-1-(2-FLUOROPHENYL)ETHANOL
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $721.88
- Updated
- 2021/12/16
(S)-1-(2-FLUOROPHENYL)ETHANOL Chemical Properties,Usage,Production
Uses
(S)?-?1-?(2-?Fluorophenyl)?ethanol is a building block used in organic synthesis such as JN403, a novel nicotinic acetylcholine receptor α7 agonist.
Synthesis
445-27-2
171032-87-4
General procedure for the synthesis of (S)-1-(2-fluorophenyl)ethanol from o-fluoroacetophenone: (R)-methyloxazole borane (0.32 g, 1.2 mmol) was dissolved in tert-butanol (60 mL) under the protection of nitrogen, N,N-diethylanilinoborane (2.6 g, 16 mmol) was added followed by a slow, titrative addition of 1-(2-fluorophenyl)ethanone at 45 °C ( 2.0 g, 14 mmol) in tert-butanol solution (150 mL) and the reaction mixture was stirred. After 1 hour of reaction, the mixture was cooled to room temperature, methanol was added and concentrated. To the concentrate, 1.0 N hydrochloric acid was added and extracted with ethyl acetate, the organic layer was washed with saturated brine and dried with anhydrous sodium sulfate sequentially, and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane to hexane/ethyl acetate=85/15) to afford the title compound (S)-1-(2-fluorophenyl)ethanol (1.9 g, 92% yield) as a colorless liquid.1H-NMR (400 MHz, CDCl3) δ: 1.52 (3H, d, J=6.8 Hz), 5.17-5.24 (1H, m ), 6.98-7.05 (1H, m), 7.15 (1H, ddd, J=1.2, 7.6, 7.6 Hz), 7.21-7.28 (1H, m), 7.49 (1H, ddd, J=1.6, 7.6, 7.6 Hz).
References
[1] Journal of the American Chemical Society, 1998, vol. 120, # 51, p. 13529 - 13530
[2] Tetrahedron: Asymmetry, 2003, vol. 14, # 6, p. 710 - 716
[3] Patent: US2018/162868, 2018, A1. Location in patent: Paragraph 1572-1573
[4] Tetrahedron Asymmetry, 2002, vol. 13, # 13, p. 1347 - 1349
[5] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4619 - 4622
(S)-1-(2-FLUOROPHENYL)ETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-1-(2-FLUOROPHENYL)ETHANOL manufacturers
- Product
- (1S)-1-(2-Fluorophenyl)ethanol 171032-87-4
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- (S)-1-(2-FLUOROPHENYL)ETHANOL 171032-87-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-02