ChemicalBook > CAS DataBase List > (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid

Product Name
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
CAS No.
1335316-40-9
Chemical Name
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
Synonyms
PLV-09-40;Velpatasvir Impurity 6;Velpatasvir Intermediate 5;(2S,5S)-1-(2-Methoxycarbonylamino-;(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline;(5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline;(2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl);L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)-;(5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline;(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic
CBNumber
CB22750330
Molecular Formula
C13H22N2O5
Formula Weight
286.32
MOL File
1335316-40-9.mol
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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Property

Melting point:
134 - 136°C
Boiling point:
489.9±40.0 °C(Predicted)
Density 
1.198±0.06 g/cm3(Predicted)
refractive index 
1.502
Flash point:
250.1 ± 27.3 °C
storage temp. 
-20°C, Inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.61±0.40(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C13H22N2O5/c1-7(2)10(14-13(19)20-4)11(16)15-8(3)5-6-9(15)12(17)18/h7-10H,5-6H2,1-4H3,(H,14,19)(H,17,18)/t8-,9-,10-/m0/s1
InChIKey
PNAXKGVRCAXIJK-GUBZILKMSA-N
SMILES
C(O)(=O)[C@@H]1CC[C@H](C)N1C(=O)[C@H](C(C)C)NC(OC)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M261343
Product name
(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
Packaging
1g
Price
$55
Updated
2021/12/16
Crysdot
Product number
CD22004812
Product name
(2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid
Purity
97%
Packaging
1g
Price
$130
Updated
2021/12/16
Chemenu
Product number
CM101923
Product name
(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
Purity
97%
Packaging
5g
Price
$224
Updated
2021/12/16
Chemenu
Product number
CM101923
Product name
(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
Purity
97%
Packaging
10g
Price
$370
Updated
2021/12/16
Crysdot
Product number
CD22004812
Product name
(2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid
Purity
97%
Packaging
5g
Price
$400
Updated
2021/12/16
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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production

Uses

(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline is an antiviral agent and Velpatasvir (V116000) intermediate. Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Synthesis

To an ice-cold stirred solution of ethyl (2S,5S)-1 -[(2S)-2- (methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidine-2- carboxylate (5.6 g, 17.8 mmol) in ethanol (18 ml) is added a solution of lithium hydroxide monohydrate (17.8 mL of 1.7 M, 30.3 mmol). The reaction mixture is stirred for 5 hours at rt. The reaction mixture is concentrated, diluted with water, washed with ether. The aqueous solution is acidified with aq. 1 N HCl, extracted with CH2CI2. The combined extracts are washed with brine, dried (Na2S04), concentrated to afford (2S,5S)-1 -[(2S)-2-(methoxycarbonylamino)-3- methyl-butanoyl]-5-methyl-pyrrolidine-2-carboxylic acid (5g, 94%) as a white solid.

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Suppliers

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View Lastest Price from (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid manufacturers

Anhui Ruihan Technology Co., Ltd
Product
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-08
Henan Aochuang Chemical Co.,Ltd.
Product
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline 1335316-40-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

1335316-40-9, (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acidRelated Search:

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) 9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one Aprepitant (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir intermediate Velpatasvir Velpatasvir intermediate Velpatasvir intermediate (R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Co Povidone Velpatasvir intermediate BOC-L-PYROGLUTAMIC ACID BENZYL ESTER Velpatasvir-A12 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one Velpatasvir intermediate -II-RS isomer (2S,4R)-4-(Methoxymethyl)-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester

  • (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
  • (2S,4S)-1-((R)-2-((methoxycarbonyl) amino)-2-phenylacetyl)-4-(methoxy methyl)pyrrolidine-2-carboxylic acid
  • (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
  • (2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid
  • 3. (2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3- methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid
  • (2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl)
  • (2S,5S)-1-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-methyl-pyrrolidine-2-carboxylic acid
  • N-[2-(S)-[(Methoxycarbonyl)amino]-3-methylbutyryl]-(5S)-5-Methyl-L-proline
  • (2S,5S)-1-((S)-2-METHOXYCARBONYLAMINO)-3-METHYLBUTYRYL)-5-METHYLPYRROLIDINE-2-CARBOXYLIC ACID
  • (2S,5S)-1-(2-Methoxycarbonylamino-
  • Velpatasvir Intermediate 5
  • Velpatasvir Impurity 6
  • (5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline
  • L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)-
  • (5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline
  • (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic
  • PLV-09-40
  • (2R,5R)-1-((S)-2-(Methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid
  • 1335316-40-9
  • 1416134-40-9