(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid

Product Name: (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
CAS No.: 1335316-40-9
Chemical Name: (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
Synonyms: PLV-09-40;Velpatasvir Impurity 6;Velpatasvir Intermediate 5;(2S,5S)-1-(2-Methoxycarbonylamino-;(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline;(5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline;(2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl);L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)-;(5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline;(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic
CBNumber: CB22750330
Molecular Formula: C13H22N2O5
Formula Weight: 286.32
MOL File: 1335316-40-9.mol

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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Property

Melting point:: 134 - 136°C
Boiling point:: 489.9±40.0 °C(Predicted)
Density: 1.198±0.06 g/cm3(Predicted)
refractive index: 1.502
Flash point:: 250.1 ± 27.3 °C
storage temp.: -20°C, Inert atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.61±0.40(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C13H22N2O5/c1-7(2)10(14-13(19)20-4)11(16)15-8(3)5-6-9(15)12(17)18/h7-10H,5-6H2,1-4H3,(H,14,19)(H,17,18)/t8-,9-,10-/m0/s1
InChIKey: PNAXKGVRCAXIJK-GUBZILKMSA-N
SMILES: C(O)(=O)[C@@H]1CC[C@H](C)N1C(=O)[C@H](C(C)C)NC(OC)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M261343
Product name: (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
Packaging: 1g
Price: $55
Updated: 2021/12/16

Crysdot

Product number: CD22004812
Product name: (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid
Purity: 97%
Packaging: 1g
Price: $130
Updated: 2021/12/16

Chemenu

Product number: CM101923
Product name: (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
Purity: 97%
Packaging: 5g
Price: $224
Updated: 2021/12/16

Chemenu

Product number: CM101923
Product name: (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
Purity: 97%
Packaging: 10g
Price: $370
Updated: 2021/12/16

Crysdot

Product number: CD22004812
Product name: (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid
Purity: 97%
Packaging: 5g
Price: $400
Updated: 2021/12/16

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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production

Uses

(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline is an antiviral agent and Velpatasvir (V116000) intermediate. Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Synthesis

To an ice-cold stirred solution of ethyl (2S,5S)-1 -[(2S)-2- (methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidine-2- carboxylate (5.6 g, 17.8 mmol) in ethanol (18 ml) is added a solution of lithium hydroxide monohydrate (17.8 mL of 1.7 M, 30.3 mmol). The reaction mixture is stirred for 5 hours at rt. The reaction mixture is concentrated, diluted with water, washed with ether. The aqueous solution is acidified with aq. 1 N HCl, extracted with CH2CI2. The combined extracts are washed with brine, dried (Na2S04), concentrated to afford (2S,5S)-1 -[(2S)-2-(methoxycarbonylamino)-3- methyl-butanoyl]-5-methyl-pyrrolidine-2-carboxylic acid (5g, 94%) as a white solid.

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Suppliers

China 159 India 6 United States 3 Global 168

Kendal Chemicals

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Pharmaffiliates Analytics and Synthetics P. Ltd

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View Lastest Price from (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid manufacturers

Anhui Ruihan Technology Co., Ltd

Product: (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-08

Henan Aochuang Chemical Co.,Ltd.

Product: (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline 1335316-40-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

1335316-40-9, (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acidRelated Search:

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) 9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one Aprepitant (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir intermediate Velpatasvir Velpatasvir intermediate Velpatasvir intermediate (R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Co Povidone Velpatasvir intermediate BOC-L-PYROGLUTAMIC ACID BENZYL ESTER Velpatasvir-A12 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one Velpatasvir intermediate -II-RS isomer (2S,4R)-4-(Methoxymethyl)-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid

(2S,4S)-1-((R)-2-((methoxycarbonyl) amino)-2-phenylacetyl)-4-(methoxy methyl)pyrrolidine-2-carboxylic acid

(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline

(2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid

3. (2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3- methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl)

(2S,5S)-1-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-methyl-pyrrolidine-2-carboxylic acid

N-[2-(S)-[(Methoxycarbonyl)amino]-3-methylbutyryl]-(5S)-5-Methyl-L-proline

(2S,5S)-1-((S)-2-METHOXYCARBONYLAMINO)-3-METHYLBUTYRYL)-5-METHYLPYRROLIDINE-2-CARBOXYLIC ACID

(2S,5S)-1-(2-Methoxycarbonylamino-

Velpatasvir Intermediate 5

Velpatasvir Impurity 6

(5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline

L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)-

(5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic

PLV-09-40

(2R,5R)-1-((S)-2-(Methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid

1335316-40-9

1416134-40-9