6-Methyl-2-pyridinecarboxaldehyde
- Product Name
- 6-Methyl-2-pyridinecarboxaldehyde
- CAS No.
- 1122-72-1
- Chemical Name
- 6-Methyl-2-pyridinecarboxaldehyde
- Synonyms
- 6-METHYLPICOLINALDEHYDE;6-METHYL-2-PYRIDINECARBALDEHYDE;dehyde, 6-methyL;6-ForMyl-2-picoline;TIMTEC-BB SBB004287;2-FORMYL-6-PICOLINE;Chlorpyrifos Impurity 53;2-FORMYL-6-METHYLPYRIDINE;6-Methyl-2-picolinaldehyde;2-picoline-6-carboxaldehyde
- CBNumber
- CB2290089
- Molecular Formula
- C7H7NO
- Formula Weight
- 121.14
- MOL File
- 1122-72-1.mol
6-Methyl-2-pyridinecarboxaldehyde Property
- Melting point:
- 31-33 °C(lit.)
- Boiling point:
- 105-108°C/12mm
- Density
- 1.1344 (rough estimate)
- refractive index
- n20/D 1.527(lit.)
- Flash point:
- 155 °F
- storage temp.
- 2-8°C
- form
- Low Melting Solid
- pka
- 3.96±0.10(Predicted)
- color
- Light yellow to brown
- Water Solubility
- 750 g/L (20 ºC)
- Sensitive
- Light Sensitive/Air Sensitive
- BRN
- 107476
- InChIKey
- AHISYUZBWDSPQL-UHFFFAOYSA-N
- CAS DataBase Reference
- 1122-72-1(CAS DataBase Reference)
- EPA Substance Registry System
- 6-Methyl-2-pyridinecarboxaldehyde (1122-72-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- RIDADR
- UN 1325
- WGK Germany
- 3
- F
- 8-9-23
- TSCA
- Yes
- HazardClass
- IRRITANT, LIGHT SENSITIVE, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M78208
- Product name
- 6-Methylpyridine-2-carboxaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $204
- Updated
- 2025/07/31
- Product number
- M78208
- Product name
- 6-Methylpyridine-2-carboxaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $1240
- Updated
- 2024/03/01
- Product number
- M1157
- Product name
- 6-Methyl-2-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- M1157
- Product name
- 6-Methyl-2-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $304
- Updated
- 2025/07/31
- Product number
- M326685
- Product name
- 6-Methyl-2-pyridinecarboxaldehyde
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
6-Methyl-2-pyridinecarboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
light yellow to brown low melting solid
Uses
6-Methyl-2-pyridinecarboxaldehyde was used in the synthesis of 1-(10-cyano- and -10-bromo-5H-dibenzo[a,d]cyclohepten-5-yl)-4-[(arylmethylene)amino]piperazines which are compounds that exhibits anticon vulsant properties. 6-Methylpyridine-2-carboxaldehyde is used to produce 1-(6-methyl-pyridin-2-yl)-hexan-1-one with pent-1-ene at temperature of 100°C. This reaction will need reagent 2-amino-3-picoline and catalysts (Ph3P)3RhCl, Cp2ZrCl2.
Synthesis
1122-71-0
1122-72-1
Under stirring conditions, 10.47 g (0.081 mol) of selenite was dissolved in 30 mL of water and the resulting solution was slowly added to a 150 mL solution of 1,4-dioxane containing 20 g (0.162 mol) of 6-methyl-2-pyridinemethanol (3a). The reaction mixture was stirred continuously at 100 °C for 6 hours. Upon completion of the reaction, the resulting metallic selenium was removed by filtration. The filtrate was distilled under reduced pressure to remove the solvent and the residue was treated by extraction with hot hexane (3 x 150 mL). After combining the extracts, the solvents were again removed by distillation under reduced pressure and the resulting product did not require further purification. Finally, 14.76 g (0.121 mol, 75% yield) of 6-methyl-2-pyridinecarboxaldehyde was obtained with a melting point of 31-33 °C. The product structure was determined by 1H NMR. The structure of the product was determined by 1H NMR (DMSO-d6, δ, ppm): 2.61 (s, 3H, Me), 7.49 (d, 1H, 5-H, J = 7.5 Hz), 7.71 (d, 1H, 3-H, J = 7.5 Hz), 7.86 (dd, 1H, 4-H, J = 7.5, 7.5 Hz), 9.93 (s, 1H, CHO) and mass spectrum (m/z 122.06, I rel 100% [M + H]+) confirmed that the calculated molecular weight was 122.06.
References
[1] Tetrahedron Letters, 1999, vol. 40, # 9, p. 1635 - 1636
[2] Organometallics, 2016, vol. 35, # 10, p. 1505 - 1513
[3] Russian Journal of Organic Chemistry, 2017, vol. 53, # 7, p. 963 - 970
[4] Zh. Org. Khim., 2017, vol. 53, # 7, p. 951 - 958,8
[5] Dalton Transactions, 2012, vol. 41, # 22, p. 6661 - 6670
6-Methyl-2-pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methyl-2-pyridinecarboxaldehyde manufacturers
- Product
- 6-Methyl-2-pyridinecarboxaldehyde 1122-72-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-03
- Product
- 6-Methyl-2-pyridinecarboxaldehyde 1122-72-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2025-02-28
- Product
- 6-Methyl-2-pyridinecarboxaldehyde 1122-72-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14