Di-o-tolylguanidine
- Product Name
- Di-o-tolylguanidine
- CAS No.
- 97-39-2
- Chemical Name
- Di-o-tolylguanidine
- Synonyms
- DTG;DOTG;NSC 473;DOTG（DT）;Nsc132023;VANAX DOTG;eveitedotg;usafa-6598;Anchor DOTG;Eveite DOTG
- CBNumber
- CB2290261
- Molecular Formula
- C15H17N3
- Formula Weight
- 239.32
- MOL File
- 97-39-2.mol
Di-o-tolylguanidine Property
- Melting point:
- 176-178 °C(lit.)
- Boiling point:
- 371.98°C (rough estimate)
- Density
- 1.1000
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.4560 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- water: soluble70mg/mL at 20°C
- pka
- 10.32±0.10(Predicted)
- form
- solid
- color
- White
- Water Solubility
- 70mg/L at 20℃
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- LogP
- 2.9 at 25℃
- CAS DataBase Reference
- 97-39-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Guanidine, 1,3-di-o-tolyl-(97-39-2)
- EPA Substance Registry System
- 1,3-Di-o-tolylguanidine (97-39-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 26-36
- RIDADR
- UN 2811
- WGK Germany
- 3
- RTECS
- MF1400000
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29252900
- Hazardous Substances Data
- 97-39-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 207713
- Product name
- 1,3-Di-o-tolylguanidine
- Purity
- 99%
- Packaging
- 5g
- Price
- $30.2
- Updated
- 2024/03/01
- Product number
- 207713
- Product name
- 1,3-Di-o-tolylguanidine
- Purity
- 99%
- Packaging
- 100g
- Price
- $36.68
- Updated
- 2024/03/01
- Product number
- D0953
- Product name
- 1,3-Di-o-tolylguanidine
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- D0953
- Product name
- 1,3-Di-o-tolylguanidine
- Purity
- >99.0%(T)
- Packaging
- 500g
- Price
- $163
- Updated
- 2024/03/01
- Product number
- B25127
- Product name
- 1,3-Di-o-tolylguanidine, 99%
- Packaging
- 100g
- Price
- $55.65
- Updated
- 2024/03/01
Di-o-tolylguanidine Chemical Properties,Usage,Production
Description
DTG (97-39-2) is an agonist of the sigma (σ) receptor1?with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2.
Uses
DTG is a selective ligand for the sigma-binding site. DTG has high binding affinity.
Definition
ChEBI: 1,2-bis(2-methylphenyl)guanidine is a member of toluenes.
General Description
1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.
Flammability and Explosibility
Non flammable
Biological Activity
Displays high and roughly equal affinity for both σ 1 and σ 2 receptors.
Safety Profile
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
The guanidine crystallises from aqueous EtOH. The sulfate has m 253-254o(dec, H2O). [Beilstein 12 H 803, 12 II 445, 12 III 1871, 16 IV 1764]
References
1) Weber?et al.?(1986),?1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc. Natl. Acad. Sci. USA,?83?8784 2) Scherz?et al.?(1990),?Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J. Med. Chem.,?33?2421
Di-o-tolylguanidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Di-o-tolylguanidine manufacturers
- Product
- Di-o-tolylguanidine 97-39-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-20
- Product
- Di-o-tolylguanidine 97-39-2
- Price
- US $40.00-9.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-26
- Product
- Di-o-tolylguanidine 97-39-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-11-13