ChemicalBook > CAS DataBase List > Di-o-tolylguanidine

Di-o-tolylguanidine

Product Name
Di-o-tolylguanidine
CAS No.
97-39-2
Chemical Name
Di-o-tolylguanidine
Synonyms
DTG;DOTG;NSC 473;DOTG（DT）;Nsc132023;VANAX DOTG;eveitedotg;usafa-6598;Anchor DOTG;Eveite DOTG
CBNumber
CB2290261
Molecular Formula
C15H17N3
Formula Weight
239.32
MOL File
97-39-2.mol
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Di-o-tolylguanidine Property

Melting point:
176-178 °C(lit.)
Boiling point:
371.98°C (rough estimate)
Density 
1.1000
vapor pressure 
0Pa at 25℃
refractive index 
1.4560 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
water: soluble70mg/mL at 20°C
pka
10.32±0.10(Predicted)
form 
solid
color 
White
Water Solubility 
70mg/L at 20℃
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
LogP
2.9 at 25℃
CAS DataBase Reference
97-39-2(CAS DataBase Reference)
NIST Chemistry Reference
Guanidine, 1,3-di-o-tolyl-(97-39-2)
EPA Substance Registry System
1,3-Di-o-tolylguanidine (97-39-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
26-36
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
MF1400000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29252900
Hazardous Substances Data
97-39-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
207713
Product name
1,3-Di-o-tolylguanidine
Purity
99%
Packaging
5g
Price
$30.2
Updated
2024/03/01
Sigma-Aldrich
Product number
207713
Product name
1,3-Di-o-tolylguanidine
Purity
99%
Packaging
100g
Price
$36.68
Updated
2024/03/01
TCI Chemical
Product number
D0953
Product name
1,3-Di-o-tolylguanidine
Purity
>99.0%(T)
Packaging
25g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
D0953
Product name
1,3-Di-o-tolylguanidine
Purity
>99.0%(T)
Packaging
500g
Price
$163
Updated
2024/03/01
Alfa Aesar
Product number
B25127
Product name
1,3-Di-o-tolylguanidine, 99%
Packaging
100g
Price
$55.65
Updated
2024/03/01
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Di-o-tolylguanidine Chemical Properties,Usage,Production

Description

DTG (97-39-2) is an agonist of the sigma (σ) receptor1?with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2.

Uses

DTG is a selective ligand for the sigma-binding site. DTG has high binding affinity.

Definition

ChEBI: 1,2-bis(2-methylphenyl)guanidine is a member of toluenes.

General Description

1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.

Flammability and Explosibility

Non flammable

Biological Activity

Displays high and roughly equal affinity for both σ 1 and σ 2 receptors.

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The guanidine crystallises from aqueous EtOH. The sulfate has m 253-254o(dec, H2O). [Beilstein 12 H 803, 12 II 445, 12 III 1871, 16 IV 1764]

References

1) Weber?et al.?(1986),?1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc. Natl. Acad. Sci. USA,?83?8784 2) Scherz?et al.?(1990),?Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J. Med. Chem.,?33?2421

Di-o-tolylguanidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Di-o-tolylguanidine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Di-o-tolylguanidine 97-39-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-20
Hebei Weibang Biotechnology Co., Ltd
Product
Di-o-tolylguanidine 97-39-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
Di-o-tolylguanidine 97-39-2
Price
US $40.00-9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-26

97-39-2, Di-o-tolylguanidineRelated Search:

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  • 2,2'-DIMETHYLIMINOCARBANILIDE
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  • dotgaccelerator
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  • N,N’-bis(2-Methylphenyl)-Guanidine
  • n,n’-di-o-tolylguanidine
  • N,N'-Di-o-toluene guanidine
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