2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL
- Product Name
- 2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL
- CAS No.
- 66158-96-1
- Chemical Name
- 2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL
- Synonyms
- AKOS BB-6927;2-BenzofuranMethanol,2,3-dihydro-;2-HydroxyMethyl-2,3-dihydrobenzofuran;2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL;(2,3-DIHYDRO-BENZOFURAN-2-YL)-METHANOL;2,3-DIHYDRO-2-(HYDROXYMETHYL)BENZOFURAN;2-HYDROXYMETHYL-2,3-DIHYDRO-1-BENZOFURAN;2,3-Dihydro-2-(hydroxymethyl)benzo[b]furan;2,3-Dihydro-2-(hydroxymethyl)benzo[b]furan97%;2-(Hydroxymethyl)-2,3-dihydro-1-benzofuran 97%
- CBNumber
- CB2290988
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 66158-96-1.mol
2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL Property
- Boiling point:
- 120-122
- Density
- 1.181 g/cm3(Temp: 16 °C)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Oil
- pka
- 14.22±0.10(Predicted)
- color
- Colorless
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 2932990090
N-Bromosuccinimide Price
- Product number
- H947870
- Product name
- 2-Hydroxymethyl-2,3-dihydrobenzofuran
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- FD142842
- Product name
- (2,3-Dihydrobenzofuran-2-yl)methanol
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- FD142842
- Product name
- (2,3-Dihydrobenzofuran-2-yl)methanol
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W7718
- Product name
- (2,3-Dihydrobenzofuran-2-yl)methanol
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
- Product number
- FD142842
- Product name
- (2,3-Dihydrobenzofuran-2-yl)methanol
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL Chemical Properties,Usage,Production
Chemical Properties
2,3-dihydrobenzofuran-2-methanol is Colorless Oil
Uses
2-Hydroxymethyl-2,3-dihydrobenzofuran (H947870) is a reactant used in the preparation of thromboxane A2 agonist indane derivatives.
Uses
2,3-dihydrobenzofuran-2-methanol is a reactant used in the preparation of thromboxane A2 agonist indane derivatives.
Synthesis
1745-81-9
66158-96-1
2-Allylphenol (5) (200 mg, 1.49 mmol) was used as a raw material, which was mixed with m-chloroperoxybenzoic acid (616 mg, 3.57 mmol) in dichloromethane (DCM, 30 mL) and the reaction was stirred for 6 hours at room temperature. Subsequently, potassium carbonate (K2CO3, 617 mg, 4.47 mmol) and methanol (25 mL) were added to the reaction system and stirring was continued for 14 hours. After completion of the reaction, the solvent was removed by evaporation and diluted by adding water (15 mL). The mixture was extracted with dichloromethane (3 x 20 mL), the organic phases were combined, washed with brine (10 mL), dried over anhydrous sodium sulfate (Na2SO4), and the solvent was evaporated again. The crude product was purified by fast column chromatography (eluent: ethyl acetate/hexane=1:7) to afford the target compound (2,3-dihydrobenzofuran-2-yl)methanol (6) (195 mg, 87% yield) as a light yellow oil. The structure of the product was confirmed by 1H NMR (CDCl3, 300 MHz) and FTIR (neat): 1H NMR δ 7.17 (d, 1H, J = 7.4 Hz), 7.11 (t, 1H, J = 7.6 Hz), 6.85 (t, 1H, J = 7.4 Hz), 6.79 (d, 1H, J = 7.4 Hz), 4.91 (m, 1H) , 3.85 (dd, 1H, J = 12.0, 3.2 Hz), 3.74 (dd, 1H, J = 12.0, 6.3 Hz), 3.25 (dd, 1H, J = 15.5, 9.4 Hz), 3.01 (dd, 1H, J = 15.5, 7.4 Hz); FTIR 3391, 3049, 1047 cm-1.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 12, p. 2545 - 2549
[2] Advanced Synthesis and Catalysis, 2007, vol. 349, # 17-18, p. 2685 - 2689
[3] Bioorganic and medicinal chemistry letters, 1999, vol. 9, # 3, p. 401 - 406
[4] Tetrahedron Asymmetry, 2000, vol. 11, # 16, p. 3375 - 3393
[5] Synthesis (Germany), 2017, vol. 49, # 18, p. 4254 - 4260
2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL Preparation Products And Raw materials
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- Product
- 2,3-DIHYDRO-1-BENZOFURAN-2-YLMETHANOL 66158-96-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18