AMCA-NHS

Product Name: AMCA-NHS
CAS No.: 113721-87-2
Chemical Name: AMCA-NHS
Synonyms: AMCA-OSU;AMCA-NHS;AMCA-H NHS;7-AMCA NHS ester;AMCA N-succinimidyl ester;AMCA-H N-succinimidyl ester;7-AMINO-4-METHYL-3-COUMARINYLACETYL;7-(DiMethylaMino)couMarin-4-aceticcid-NHS;7-(Dimethylamino)coumarin-4-acetic acid-NHS;SUCCINIMIDYL-7-AMINO-4-METHYLCOUMARIN-3-ACETATE
CBNumber: CB2298838
Molecular Formula: C16H14N2O6
Formula Weight: 330.29
MOL File: 113721-87-2.mol

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AMCA-NHS Property

Boiling point:: 559.4±60.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMF: soluble
pka: 1.69±0.20(Predicted)
form: A solid
Appearance: Light yellow solid
ex/em: 353/455 nm
ε(extinction coefficient): 19000 L⋅mol−1⋅cm−1
BRN: 9007679
InChI: InChI=1S/C16H14N2O6/c1-8-10-3-2-9(17)6-12(10)23-16(22)11(8)7-15(21)24-18-13(19)4-5-14(18)20/h2-3,6H,4-5,7,17H2,1H3
InChIKey: ILKQVTIMOGNSAS-UHFFFAOYSA-N
SMILES: C1(=O)OC2=CC(N)=CC=C2C(C)=C1CC(ON1C(=O)CCC1=O)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8-10-21
HS Code: 3212900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 08450
Product name: 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester
Purity: BioReagent, suitable for fluorescence, ≥90% (HPLC)
Packaging: 5mg
Price: $297.35
Updated: 2025/07/31

TRC

Product number: A634433
Product name: 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester
Packaging: 10mg
Price: $385
Updated: 2021/12/16

TRC

Product number: A634433
Product name: 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester
Packaging: 5mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA170610
Product name: 7-Amino-4-methyl-3-coumarinacetic acid?N-succinimidyl ester
Packaging: 100mg
Price: $250
Updated: 2021/12/16

Iris Biotech GmbH

Product number: RL-1005
Product name: AMCA-OSu
Packaging: 250mg
Price: $270
Updated: 2021/12/16

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AMCA-NHS Chemical Properties,Usage,Production

Description

Activated NHS-ester of AMCA (aminomethyl coumarin acetate) dye. This NHS ester is an amine-reactive dye for labeling of amine groups in proteins, peptides, amino-modified oligos, and other target molecules.

AMCA is one of the brightest blue fluorescent dyes. This fluorophore has a relatively large Stoke’s shift, high resistance to photobleaching, and pH-independent fluorescence from pH 4 to 10. AMCA is a widely used fluorophore for multiple-color labeling due to its minimal fluorescence overlap with green- and longer wavelength-emitting fluorescent dyes.

Chemical Properties

Appearance: Pale yellow solid
ex/em: 353/455 nm
Extinction coefficient (ε): 19000 L??mol??1??cm??1

Uses

AMCA-H NHS ester reacts with primary amines at pH 7.0-9.0. Suitable for labeling lysyl residues in proteins.

Abs/Em Maxima

348/435 nm

Fluoresene quantum yield

0.91

Extinction Coefficient

17400

CF260

0.16

CF280

0.13

AMCA-NHS Preparation Products And Raw materials

Raw materials

Preparation Products

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AMCA-NHS Suppliers

China 52 Europe 1 Germany 4 Switzerland 2 United Kingdom 4 United States 8 Global 71

Shanghai Annengjian Biomedical Technology Co., LTD

Tel: 021-68781987 13818305065
Email: sales@energybiopharma.com
Country: China
ProdList: 652
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Tianjin Being Technology Co., Ltd.

Tel: 18622939839
Fax: QQ:343281693
Email: tjby921@163.com
Country: China
ProdList: 884
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

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View Lastest Price from AMCA-NHS manufacturers

Career Henan Chemical Co

Product: (2,5-dioxopyrrolidin-1-yl) 2-(7-amino-4-methyl-2-o 113721-87-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

113721-87-2, AMCA-NHSRelated Search:

N-Acetoxysuccinimide Ammonium succinate 3-METHYL-CHROMEN-2-ONE 4-METHYL-3-PENTENOIC ACID N-Hydroxysuccinimide 4-Phenoxybutanoic acid (E)-Ethylidenesuccinic acid trans-Styrylacetic acid PHENYL METHACRYLATE N-Methoxy-N-methylacetamide 2,5-dioxopyrrolidin-1-yl propanoate 3-(ALLYLOXY)ANILINE N-METHOXY-N-METHYL-PROPIONAMIDE N,N,O-TRIACETYLHYDROXYLAMINE Coumarin 120 CHEMBRDG-BB 4023581 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID AMCA-NHS

AMCA-H NHS

7-(Dimethylamino)coumarin-4-acetic acid-NHS

SUCCINIMIDYL-7-AMINO-4-METHYLCOUMARIN-3-ACETATE

N-SUCCINIMIDYL 7-AMINO-4-METHYL-3-COUMARINYLACETATE

AMCA-NHS

AMCA-OSU

7-AMINO-4-METHYL-3-COUMARINACETIC ACID N-SUCCINIMIDYL ESTER

7-AMINO-4-METHYL-3-COUMARINYLACETYL

7-AMINO-4-METHYL-3-COUMARINYLACETYL SUCCINIMIDYL ESTER

(2,5-dioxopyrrolidin-1-yl) 2-(7-amino-4-methyl-2-o

2,5-Pyrrolidinedione, 1-[[(7-aMino-4-Methyl-2-oxo-2H-1-benzopyran-3-yl)acetyl]oxy]-

7-(DiMethylaMino)couMarin-4-aceticcid-NHS

AMCA NHS, 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester

AMCA-H N-succinimidyl ester

AMCA, SE [7-Amino-4-methyl-3-coumaricetic acid N-succinimidyl ester]

AMCA, SE [7-AMino-4-Methyl-3-couMarinacetic acid N-succiniMidyl ester]

2H-1-Benzopyran-3-acetic acid, 7-amino-4-methyl-2-oxo-, 2,5-dioxo-1-pyrrolidinyl ester

7-AMCA NHS ester

2,5-dioxopyrrolidin-1-yl 2-(7-amino-4-methyl-2-oxo-2H-chromen-3-yl)acetate

AMCA N-succinimidyl ester

7-Amino-4-methyl-3-coumarinacetic acid <i>N</i>-succinimidyl ester

113721-87-2

Biochemicals and Reagents

BioChemical

Fluorescent Probes, Labels, Particles and Stains

Fluorescent Labels

Other Fluorescent Labels

proteinmod