ChemicalBook > CAS DataBase List > Diethyl pyrocarbonate

Diethyl pyrocarbonate

Product Name
Diethyl pyrocarbonate
CAS No.
1609-47-8
Chemical Name
Diethyl pyrocarbonate
Synonyms
DEPC;DIETHYL DICARBONATE;Ethyl pyrocarbonate;DKD;Piref;Baycovin;DEP／DEPC;ethylpyrocarbonate;Diethylpyrokarbonat;iethylpyrocarbonate
CBNumber
CB2300384
Molecular Formula
C6H10O5
Formula Weight
162.14
MOL File
1609-47-8.mol
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Diethyl pyrocarbonate Property

Melting point:
69℃
Boiling point:
93-94 °C18 mm Hg(lit.)
Density 
1.12 g/mL at 20 °C
refractive index 
n20/D 1.398(lit.)
Flash point:
157 °F
storage temp. 
2-8°C
solubility 
95% ethanol: soluble4.5g/10 mL, clear, colorless
form 
Liquid
color 
APHA: ≤20
Water Solubility 
slow decomposition
Sensitive 
Moisture Sensitive
Merck 
14,7998
BRN 
637031
Stability:
Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia.
InChIKey
FFYPMLJYZAEMQB-UHFFFAOYSA-N
LogP
1.101 (est)
CAS DataBase Reference
1609-47-8(CAS DataBase Reference)
NIST Chemistry Reference
Diethyl pyrocarbonate(1609-47-8)
EPA Substance Registry System
Dicarbonic acid, diethyl ester (1609-47-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36-37/39
RIDADR 
2810
WGK Germany 
3
RTECS 
LQ9350000
F 
4.4-9-21
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29209085
Toxicity
LD50 orally in Rabbit: 850 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41751
Product name
Diethyl dicarbonate
Purity
for synthesis
Packaging
5ml
Price
$35.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41751
Product name
Diethyl dicarbonate
Purity
for synthesis
Packaging
25mL
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
298711
Product name
Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem
Purity
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.
Packaging
25g
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
3660-OP
Product name
OmniPur DEPC - CAS 1609-47-8 - Calbiochem
Packaging
25g
Price
$269
Updated
2024/03/01
Sigma-Aldrich
Product number
298711
Product name
Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem
Purity
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.
Packaging
100g
Price
$547
Updated
2024/03/01
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Diethyl pyrocarbonate Chemical Properties,Usage,Production

Chemical Properties

liquid

Uses

Modification reagent for His and Tyr residues in proteins. Robust probe for structural disruptions in dsDNA, reacting with fully or partially unstacked bases.1

Uses

Diethyl pyrocarbonate may be used in the following studies:

  • For the modification of histidyl residues in proteins.
  • As a nuclease inhibitor, for the extraction of undegraded nucleic acids from etiolated and green plant tissues.
  • For the modification of linear and supercoiled plasmid DNAs.
  • As a chemical probe to investigate the secondary structure in negatively supercoiled DNA.
  • For cabethoxylation of histidine residues of actin.

Uses

Gentle esterifying agent. Preservative for wines, soft drinks, fruit juices.

Definition

ChEBI: The diethyl ester of dicarbonic acid.

General Description

Diethyl pyrocarbonate (DEP) is a bactericidal agent and decomposes in water to CO2 and ethanol. DEP inhibits enzymes such as DNase and RNase without affecting nucleic acids. It is useful for the preparation of mRNA from tissues.

Biochem/physiol Actions

Inactivates RNase in solution at about 0.1% (v/v), thus protecting RNA against degradation.

Safety Profile

Poison by ingestion, inhalation, and intraperitoneal routes. Concentrated DEPC is irritating to eyes, mucous membranes, and sh. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS.

Purification Methods

Dissolve the ester in Et2O, wash it with dilute HCl, H2O, dry over Na2SO4, filter, evaporate and distil the residue first in vacuo then at atmospheric pressure. It is soluble in alcohols, esters, ketones and hydrocarbon solvents. A 50% w/w solution is usually prepared for general use. Treat with great CAUTION as DEP irritates the eyes, mucous membranes and skin. [Boehm & Mehta Chem Ber 71 1797 1938, Thoma & Rinke Justus Liebigs Ann Chem 624 30 1959, Beilstein 3 IV 18.]

Diethyl pyrocarbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diethyl pyrocarbonate manufacturers

Hebei Kingfiner Technology Development Co.Ltd
Product
Diethyl pyrocarbonate 1609-47-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG
Release date
2024-03-26
Hebei Kingfiner Technology Development Co.Ltd
Product
Diethyl pyrocarbonate 1609-47-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-03-26
Hebei Mojin Biotechnology Co., Ltd
Product
Diethyl pyrocarbonate 1609-47-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30

1609-47-8, Diethyl pyrocarbonateRelated Search:

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