Neocryptotanshinone

Product Name: Neocryptotanshinone
CAS No.: 109664-02-0
Chemical Name: Neocryptotanshinone
Synonyms: Neocryptotanshinone;(R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione;5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione;1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-
CBNumber: CB23037421
Molecular Formula: C19H22O4
Formula Weight: 314.38
MOL File: 109664-02-0.mol

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Neocryptotanshinone Property

Boiling point:: 517.1±50.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.50±1.00(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20,22H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChIKey: PKEGICXVZMKJPR-JTQLQIEISA-N
SMILES: C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1[C@@H](C)CO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077856
Product name: Neocryptotanshinone
Purity: 98.82%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0077856
Product name: Neocryptotanshinone
Purity: 98.82%
Packaging: 10mg
Price: $920
Updated: 2021/12/16

Arctom

Product number: CFN92181
Product name: Neocryptotanshinone
Purity: ≥98%
Packaging: 10mg
Price: $398
Updated: 2021/12/16

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Neocryptotanshinone Chemical Properties,Usage,Production

Uses

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

in vivo

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)^[3].

Animal Model:	MSU-induced pain model in male ICR mice (weighing 20-25 g)^[2]
Dosage:	10, 25, 50 or 100 mg/kg
Administration:	Oral gavage; for 30, 60, 120 min
Result:	Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

IC 50

iNOS

References

[1] Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9. DOI:10.1016/j.apsb.2015.01.010
[2] H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. DOI:10.1021/np000345v
[3] FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226. PMID:33825401

Neocryptotanshinone Preparation Products And Raw materials

Raw materials

Preparation Products

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Neocryptotanshinone Suppliers

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109664-02-0, NeocryptotanshinoneRelated Search:

Tanshinone IIA Salvianolic acid Salvianolicacid C 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid magnessium lithospermate B 9'''-MethyllithosperMate B 9'''-MethyllithosperMate B Sodium danshensu TanshinoneIIA 7-Ethyl-10-hydroxycamptothecin 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione 1,2-Didehydrocryptotanshinone (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione TANSHINONE ⅡA Cryptotanshinone

Neocryptotanshinone

5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione

1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-

(R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione

109664-02-0