ChemicalBook > CAS DataBase List > Neocryptotanshinone

Neocryptotanshinone

Product Name
Neocryptotanshinone
CAS No.
109664-02-0
Chemical Name
Neocryptotanshinone
Synonyms
Neocryptotanshinone;(R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione;5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione;1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-
CBNumber
CB23037421
Molecular Formula
C19H22O4
Formula Weight
314.38
MOL File
109664-02-0.mol
More
Less

Neocryptotanshinone Property

Boiling point:
517.1±50.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
4.50±1.00(Predicted)
color 
Light yellow to yellow
InChI
InChI=1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20,22H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChIKey
PKEGICXVZMKJPR-JTQLQIEISA-N
SMILES
C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1[C@@H](C)CO
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0077856
Product name
Neocryptotanshinone
Purity
98.82%
Packaging
5mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0077856
Product name
Neocryptotanshinone
Purity
98.82%
Packaging
10mg
Price
$920
Updated
2021/12/16
Arctom
Product number
CFN92181
Product name
Neocryptotanshinone
Purity
≥98%
Packaging
10mg
Price
$398
Updated
2021/12/16
More
Less

Neocryptotanshinone Chemical Properties,Usage,Production

Uses

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

in vivo

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3].

Animal Model:MSU-induced pain model in male ICR mice (weighing 20-25 g)[2]
Dosage:10, 25, 50 or 100 mg/kg
Administration:Oral gavage; for 30, 60, 120 min
Result:Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

IC 50

iNOS

References

[1] Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9. DOI:10.1016/j.apsb.2015.01.010
[2] H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. DOI:10.1021/np000345v
[3] FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226. PMID:33825401

Neocryptotanshinone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Neocryptotanshinone Suppliers

China 66 United States 4 Global 70
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

109664-02-0, NeocryptotanshinoneRelated Search:

Tanshinone IIA Salvianolic acid Salvianolicacid C 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid magnessium lithospermate B 9'''-MethyllithosperMate B 9'''-MethyllithosperMate B Sodium danshensu TanshinoneIIA 7-Ethyl-10-hydroxycamptothecin 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione 1,2-Didehydrocryptotanshinone (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione TANSHINONE ⅡA Cryptotanshinone

  • Neocryptotanshinone
  • 5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione
  • 1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-
  • (R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione
  • 109664-02-0