ChemicalBook > CAS DataBase List > Phenytoin sodium

Phenytoin sodium

Product Name
Phenytoin sodium
CAS No.
630-93-3
Chemical Name
Phenytoin sodium
Synonyms
DILANTIN;di-len;ditoin;epelin;epinat;eptoin;enkefal;tacosal;alepsin;dihydan
CBNumber
CB2304645
Molecular Formula
C15H13N2NaO2
Formula Weight
276.27
MOL File
630-93-3.mol
More
Less

Phenytoin sodium Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
aqueous base: soluble
form 
Crystalline Powder
color 
White to almost white
Merck 
14,7322
BCS Class
2
Stability:
Hygroscopic
InChIKey
FJPYVLNWWICYDW-UHFFFAOYSA-M
CAS DataBase Reference
630-93-3(CAS DataBase Reference)
EPA Substance Registry System
Diphenylhydantoin sodium (630-93-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-43-62-63
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
MU1400000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29332100
Toxicity
LD50 orally in mice: 490 mg/kg (Fink, Swinyard)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4505
Product name
5,5-Diphenylhydantoin sodium salt
Purity
≥99%
Packaging
25g
Price
$63.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1535507
Product name
Phenytoin sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
D1331
Product name
5,5-Diphenylhydantoin Sodium Salt
Purity
>98.0%(T)
Packaging
25g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D1331
Product name
5,5-Diphenylhydantoin Sodium Salt
Purity
>98.0%(T)
Packaging
500g
Price
$271
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1492
Product name
Phenytoin sodium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$105
Updated
2024/03/01
More
Less

Phenytoin sodium Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder, slightly hygroscopic.

Uses

antibacterial

Uses

Antiepileptic

Uses

5,5-Diphenylhydantoin sodium salt has been used:

  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

brand name

Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].

General Description

Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.

Clinical Use

Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.

Safety Profile

Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.

Carcinogenicity

Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.

Solubility in water

1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.

Phenytoin sodium Preparation Products And Raw materials

Raw materials

Benzil

Preparation Products

More
Less

Phenytoin sodium Suppliers

Americas 1 Belgium 2 Brazil 2 Canada 4 China 252 Cyprus 1 Czech Republic 1 Europe 3 France 2 Germany 6 India 97 Indonesia 1 Italy 4 Japan 2 Malaysia 1 Mexico 1 Nigeria 1 South Korea 1 Switzerland 1 The Netherlands 3 United Arab Emirates 1 United Kingdom 10 United States 47 Venezuela 1 Global 445
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
Advantage
60
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
Alcon Biosciences Private Limited
Tel
--
Fax
--
Country
India
ProdList
8
Advantage
58
Royal Trading Corporation
Tel
--
Fax
--
Country
India
ProdList
135
Advantage
58
Merit International
Tel
--
Fax
--
Email
meritasia2@gmail.com
Country
India
ProdList
226
Advantage
58
Shree Ganesh Pharmaceuticals
Tel
--
Fax
--
Country
India
ProdList
20
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Euro-India Chems Pvt., Ltd.
Tel
--
Fax
--
Email
euroindiachems@gmail.com
Country
India
ProdList
31
Advantage
58
Aquatic Remedies Private Ltd
Tel
--
Fax
--
Country
India
ProdList
33
Advantage
58
Zeon Pharma (Div. of Zeon. Health Ind.)
Tel
--
Fax
--
Email
info@zeonpharma.com
Country
India
ProdList
38
Advantage
58
Novas International
Tel
--
Fax
--
Email
info@novasinternational.com
Country
India
ProdList
210
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
Ayon PharmaChem
Tel
--
Fax
--
Email
bhargav@ayonpharmachem.com
Country
India
ProdList
303
Advantage
58
Unimax Chemicals Pvt. Ltd.
Tel
--
Fax
--
Email
info@unimax.co.in
Country
India
ProdList
39
Advantage
58
Polydrug Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
polydrug@polydrug.com
Country
India
ProdList
131
Advantage
58
Tradeimpex International
Tel
--
Fax
--
Email
info@tradeimpexintl.com
Country
India
ProdList
64
Advantage
58
Opulent Pharma
Tel
--
Fax
--
Country
India
ProdList
810
Advantage
58
Samchem India
Tel
--
Fax
--
Email
varun@samchem.in
Country
India
ProdList
48
Advantage
58
Newedge Overseas
Tel
--
Fax
--
Email
info@newedgeoverseas.com
Country
India
ProdList
109
Advantage
58
Doshil
Tel
--
Fax
--
Country
India
ProdList
117
Advantage
58
SWATI SPENTOSE PRIVATE LTD
Tel
--
Fax
--
Email
info@spentose.com
Country
India
ProdList
34
Advantage
58
Siddharth International
Tel
--
Fax
--
Country
India
ProdList
107
Advantage
58
Luconic Chemicals
Tel
--
Fax
--
Country
India
ProdList
72
Advantage
58
Exim-Pharm International
Tel
--
Fax
--
Email
devdhar65@gmail.com
Country
India
ProdList
112
Advantage
58
Mesha Pharma Private Limited
Tel
--
Fax
--
Country
India
ProdList
133
Advantage
58
Gemini Exports
Tel
--
Fax
--
Email
uiry@geminiexpor
Country
India
ProdList
140
Advantage
58
Bridge Chem Pvt., Ltd.
Tel
--
Fax
--
Email
exports@bridgechem.com
Country
India
ProdList
128
Advantage
58
Metro Exporters Pvt. Ltd.
Tel
--
Fax
--
Email
metro@metroexporters.net
Country
India
ProdList
204
Advantage
58
Aastrid International Pvt., Ltd.
Tel
--
Fax
--
Email
anu.jagtap@aastrid.com
Country
India
ProdList
113
Advantage
58
Genpharma International Pvt. Ltd
Tel
--
Fax
--
Country
India
ProdList
10
Advantage
58
Aligns International
Tel
--
Fax
--
Email
info@aligns.in
Country
India
ProdList
137
Advantage
58
HiMedia Laboratories
Tel
--
Fax
--
Email
o@himedialabs.com
Country
India
ProdList
1841
Advantage
58
Unicorn Pharmachem Private Limited.
Tel
--
Fax
--
Email
falguni.g@unicornpharmachem.com
Country
India
ProdList
114
Advantage
58
Megha Health Care Pvt., Ltd.
Tel
--
Fax
--
Email
meghahealthcare@hotmail.com
Country
India
ProdList
126
Advantage
58
Innovative Synthetic Molecules
Tel
--
Fax
--
Country
India
ProdList
526
Advantage
58
Orgamine Chemicals(I) Pvt., Ltd.
Tel
--
Fax
--
Email
info@orgamine.com
Country
India
ProdList
7
Advantage
58
Vitalchemie Exim Pvt., Ltd.
Tel
--
Fax
--
Email
enquiries@vitalchemie.com
Country
India
ProdList
85
Advantage
58
A. S. Joshi & Company
Tel
--
Fax
--
Country
India
ProdList
69
Advantage
58
PR Pharma Source Pvt Ltd
Tel
--
Fax
--
Email
info@prpharmasource.in
Country
India
ProdList
37
Advantage
58
Parth Overseas
Tel
--
Fax
--
Email
sales@parthoverseas.in
Country
India
ProdList
50
Advantage
58
Shubham Pharmachem Pvt., Ltd.
Tel
--
Fax
--
Email
shubham@shubham.co.in
Country
India
ProdList
97
Advantage
58
Ralington Pharma.
Tel
--
Fax
--
Email
info@ralingtonpharma.com
Country
India
ProdList
311
Advantage
58
Dolace Solutions Private Limited
Tel
--
Fax
--
Email
info@dolacesolutions.com
Country
India
ProdList
240
Advantage
58
Unichem Laboratories Ltd.
Tel
--
Fax
--
Email
pankaj.manjrekar@unichemlabs.com
Country
India
ProdList
35
Advantage
58
Anzen Exports
Tel
--
Fax
--
Email
info@anzen.co.in
Country
India
ProdList
164
Advantage
58
Unisource Chemicals Private Limited
Tel
--
Fax
--
Country
India
ProdList
289
Advantage
58
Inchem Laboratories Pvt. Ltd
Tel
--
Fax
--
Country
India
ProdList
6
Advantage
58
Rawia International HealthCare Pvt. Ltd.
Tel
--
Fax
--
Email
info@rawia.in
Country
India
ProdList
170
Advantage
58
More
Less

View Lastest Price from Phenytoin sodium manufacturers

Sinoway Industrial co., ltd.
Product
Phenytoin sodium 630-93-3
Price
US $0.00/kg
Min. Order
2kg
Purity
99%
Supply Ability
20tons
Release date
2024-03-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Phenytoin sodium 630-93-3
Price
US $1.00/Kg/Bag
Min. Order
1KG
Purity
98.0%~102.0%,USP40
Supply Ability
5ton/month
Release date
2021-06-05
Hangzhou Hyper Chemicals Limited
Product
Phenytoin sodium 630-93-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
USP, BP, EP
Supply Ability
5,000KG
Release date
2024-06-28

630-93-3, Phenytoin sodiumRelated Search:

Sodium citrate Sodium hydroxide Sodium acetate Diphenylmethane Sodium chloride Sodium bicarbonate DIPHENYLCYCLOPROPENONE Chlorodiphenylphosphine Sodium benzoate Diphenylphosphine Imidazolidinyl urea Trisodium phosphate Sodium alginate tert-Butylchlorodiphenylsilane Biphenyl Diclofenac sodium 5,5-Diphenylhydantoin 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

  • solantoin
  • solantyl
  • 5,5-DIPHENYLHYDANTOIN SODIUM
  • 5,5-DIPHENYLHYDANTOIN SODIUM SALT
  • 4-imidazolidinedione,5,5-diphenyl-monosodiumsalt
  • 5,5-diphenyl-hydantoimonosodiumsalt
  • 5,5-diphenylhydantoinsodiumsigmaultra
  • dilantinsodium
  • di-len
  • diphenin
  • diphenine
  • dipheninesodium
  • diphentoin
  • diphenylansodium
  • diphenylhydantoinsodium
  • ditoin
  • enkefal
  • epanutin
  • epelin
  • epilan-d
  • epinat
  • eptoin
  • fenitoinsodium
  • hidantalsodium
  • hydantin
  • hydantoinal
  • lepitoinsodium
  • novodiphenyl
  • sodium 5,5-diphenyl-2,4-imidazolidinedione
  • SODIUM 5,5-DIPHENYLHYDANTOIN
  • SODIUM DIPHENYLHYDANTOIN
  • PHENYTOIN SODIUM
  • PHENYTOIN SODIUM SALT
  • PHENYLTOIN SODIUM
  • DIPHENYLHYDANTOIN SODIUM SALT
  • DILANTIN
  • PHENYTOIN SODIUM (5,5-DIPHENYLIMIDAZOLIDINE-2,4-DIONE SODIUM)
  • 5,5-Diphenylhydantoin sodium salt, 98%, a potent multi-channel blocker
  • 5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE, 5,5-DIPHENYLHYDANTOIN SODIUM SALT
  • 5,5-Diphenylhydantoin sodium salt Solution, 100ppm
  • 2,4-Imidazolidinedione, 5,5-diphenyl-, sodium salt (1:1)
  • solublephenytoin
  • tacosal
  • 5,5-Diphenylhydatoin sodium salt
  • PHENYTOINUM NATRICUM
  • 2,4-Imidazolidinedione, 5,5-diphenyl-, monosodium salt
  • PHENYTOINSODIUM,USP
  • DIPHENYLHYDANTOINESODIUM
  • 5,5-Diphenyl-2,4
  • 5,5-DIPHENYLHYDANTOIN SODIUM SALT 98+%
  • 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
  • 5,5-diphenyl-2,4-imidazolidinedione monosodium salt
  • 5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE SODIUM SALT
  • 5,5-diphenyl-hydantoisodiumsalt
  • alepsin
  • aleviatinsodium
  • auranile
  • denylsodium