XY1

Product Name: XY1
CAS No.: 1624117-53-8
Chemical Name: XY1
Synonyms: XY1;XY1 NEW;CS-2431;XY1; XY 1;XY1;XY-1;XY 1;XY1, 10 mM in DMSO;XY-1 (Negative of SGC-707);N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea;Inhibitor,XY 1,inhibit,XY-1,Histone Methyltransferase,XY1;Urea, N-2-naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-
CBNumber: CB23060845
Molecular Formula: C17H19N3O2
Formula Weight: 297.35
MOL File: 1624117-53-8.mol

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XY1 Property

Boiling point:: 514.8±42.0 °C(Predicted)
Density: 1.284±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 12.62±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17518
Product name: XY1
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 17518
Product name: XY1
Purity: ≥98%
Packaging: 10mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 17518
Product name: XY1
Purity: ≥98%
Packaging: 25mg
Price: $467
Updated: 2024/03/01

Cayman Chemical

Product number: 17518
Product name: XY1
Purity: ≥98%
Packaging: 50mg
Price: $826
Updated: 2024/03/01

Tocris

Product number: 5450
Product name: XY1
Purity: ≥98%(HPLC)
Packaging: 50
Price: $645
Updated: 2021/12/16

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XY1 Chemical Properties,Usage,Production

Description

Protein arginine N-methyltransferase 3 (PRMT3, ) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 is a potent, selective allosteric inhibitor of PRMT3 (IC₅₀ = 50 nM). It inhibits the methylation of histones in cells with an IC₅₀ value below 1 μM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 μM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.

Uses

XY1 acts as a close analog of SGC707 that is completely inactive against PRMT3, inhibiting the methylation of histones in cells.

storage

Store at +4°C

References

[1] J TANG. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation.[J]. The Journal of Biological Chemistry, 1998, 273 27: 16935-16945. DOI: 10.1074/jbc.273.27.16935
[2] WOLF S S. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans.[J]. Cellular and Molecular Life Sciences, 2009, 66 13: 2109-2121. DOI: 10.1007/s00018-009-0010-x
[3] DR. H. üMIT KANISKAN. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)?[J]. Angewandte Chemie International Edition, 2015, 54 17: 5166-5170. DOI: 10.1002/anie.201412154

XY1 Preparation Products And Raw materials

Raw materials

Preparation Products

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XY1 Suppliers

China 71 India 1 United Kingdom 1 United States 10 Global 83

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4795
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 983
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
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Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
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ProdList: 646
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ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

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View Lastest Price from XY1 manufacturers

Career Henan Chemical Co

Product: N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea 1624117-53-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1624117-53-8, XY1Related Search:

1-Methylpyrrole (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 1-Methylpyrrolidine N-ethyl-pyrrolidone N-(2-Hydroxyethyl)-2-pyrrolidone

XY1

XY-1 (Negative of SGC-707)

XY1;XY-1;XY 1

CS-2431

1-(naphthalen-2-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

XY1 NEW

N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea

XY1; XY 1

Urea, N-2-naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-

Inhibitor,XY 1,inhibit,XY-1,Histone Methyltransferase,XY1

XY1, 10 mM in DMSO

1624117-53-8

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