Hydroxy-PEG1-CH2CO2tBu

Product Name: Hydroxy-PEG1-CH2CO2tBu
CAS No.: 287174-32-7
Chemical Name: Hydroxy-PEG1-CH2CO2tBu
Synonyms: tert-Butyl 2-(2-hydroxyethoxy)acetate;HO-PEG1-CH2COOtBu;OH-PEG1-CH2COOtBu;Hydroxy-PEG1-CH2-Boc;Hydroxy-PEG1-CH2COOtBu;Hydroxy-PEG1-CH2CO2tBu;Hydroxy-PEG1-t-butyl acetate;tert-Butyl (2-hydroxyethoxy)acetate;tert-butyl 2-(2-hydroxyethoxy)acetate(WXPC0081);Acetic acid, 2-(2-hydroxyethoxy)-, 1,1-dimethylethyl ester
CBNumber: CB23062506
Molecular Formula: C8H16O4
Formula Weight: 176.21
MOL File: 287174-32-7.mol

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Hydroxy-PEG1-CH2CO2tBu Property

Boiling point:: 257.0±15.0 °C(Predicted)
Density: 1.048±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
form: liquid
pka: 14.26±0.10(Predicted)
color: Colourless
InChI: InChI=1S/C8H16O4/c1-8(2,3)12-7(10)6-11-5-4-9/h9H,4-6H2,1-3H3
InChIKey: GIDDJWYPWOFCCS-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)COCCO

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H953278
Product name: Hydroxy-PEG1-CH2CO2tBu
Packaging: 100mg
Price: $310
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1435
Product name: Hydroxy-PEG1-CH2CO2tBu
Packaging: 1g
Price: $334
Updated: 2021/12/16

BroadPharm

Product number: BP-22058
Product name: Hydroxy-PEG1-CH2CO2tBu
Purity: 95%
Packaging: 500mg
Price: $380
Updated: 2021/12/16

AK Scientific

Product number: 7470DN
Product name: Tert-butyl2-(2-hydroxyethoxy)acetate
Packaging: 1g
Price: $579
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1435
Product name: Hydroxy-PEG1-CH2CO2tBu
Packaging: 250mg
Price: $109
Updated: 2021/12/16

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Hydroxy-PEG1-CH2CO2tBu Chemical Properties,Usage,Production

Description

Hydroxy-PEG1-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Hydroxy-PEG1-CH2CO2tBu Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxy-PEG1-CH2CO2tBu Suppliers

China 70 India 1 United Kingdom 1 United States 5 Global 77

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287174-32-7, Hydroxy-PEG1-CH2CO2tBuRelated Search:

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Hydroxy-PEG1-CH2COOtBu

HO-PEG1-CH2COOtBu

tert-Butyl 2-(2-hydroxyethoxy)acetate

OH-PEG1-CH2COOtBu

tert-butyl 2-(2-hydroxyethoxy)acetate(WXPC0081)

Hydroxy-PEG1-CH2CO2tBu

Hydroxy-PEG1-t-butyl acetate

tert-Butyl (2-hydroxyethoxy)acetate

Hydroxy-PEG1-CH2-Boc

Acetic acid, 2-(2-hydroxyethoxy)-, 1,1-dimethylethyl ester

287174-32-7

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