ChemicalBook > CAS DataBase List > PQR620

PQR620

Product Name: PQR620
CAS No.: 1927857-56-4
Chemical Name: PQR620
Synonyms: PQR620;PQR620 ，S8784;PQR-620;PQR 620;PQR620, 10 mM in DMSO;PQR620;PQR-620;PQR 620;mTOR,PQR-620,PQR 620,PQR620,Mammalian target of Rapamycin,Inhibitor,inhibit;5-[4,6-Bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine;2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-;5-(4,6-Di((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl)-4-(difluoromethyl)pyridin-2-amine;5-(4-((1r,5s)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl)-4-(difluoromethyl)pyridin-2-amine
CBNumber: CB23152087
Molecular Formula: C21H25F2N7O2
Formula Weight: 445.47
MOL File: 1927857-56-4.mol

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PQR620 Property

Boiling point:: 706.8±70.0 °C(Predicted)
Density: 1.403±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6.4 mg/mL (14.37 mM)
form: Solid
pka: 5.12±0.10(Predicted)
color: White to yellow

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5948
Product name: PQR620
Purity: 98.06%
Packaging: 1mg
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-5948
Product name: PQR620
Purity: 98.06%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5948
Product name: PQR620
Purity: 98.06%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-5948
Product name: PQR620
Purity: 98.06%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573404
Product name: PQR620
Purity: >98%
Packaging: 250mg
Price: $2395.3
Updated: 2021/12/16

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PQR620 Chemical Properties,Usage,Production

Uses

PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2[1].

in vivo

The physico-chemical properties of PQR620 result in good oral bioavailability and excellent brain penetration^[1]. The activity of PQR620 as single agent undergoes in vivo evaluation in two DLBCL models, the germinal center B cell type DLBCL (GCB-DLBCL) SU-DHL-6 and the acivated B cell-like DLBCL (ABC-DLBCL) RIVA. Treatments with PQR620 (100 mg/kg dose per day, Qd×7/w) start with 100-150 mm³ tumors and are carried for 14 (SU-DHL-6) or 21 days (RIVA). In both models, PQR620 determines a 2-fold decrease of the tumor volumes in comparison with control, with significant differences in both SU-DHL-6 (D7, D9, D11, D14; P<0.005) and RIVA (D14, D16, D19, D21; P<0.005)^[2].

IC 50

mTORC1; mTORC2

References

[1] Florent Beaufils, et al. Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research; 2016 Apr 16-20.
[2] Chiara Tarantelli, et al. Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax. Blood 2016 128:3017.

PQR620 Preparation Products And Raw materials

Raw materials

Preparation Products

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1927857-56-4, PQR620Related Search:

PPQ-102 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea PQR530

PQR620

PQR-620;PQR 620

PQR620;PQR-620;PQR 620

2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-

mTOR,PQR-620,PQR 620,PQR620,Mammalian target of Rapamycin,Inhibitor,inhibit

5-(4,6-Di((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl)-4-(difluoromethyl)pyridin-2-amine

5-[4,6-Bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine

PQR620, 10 mM in DMSO

PQR620 ，S8784

5-(4-((1r,5s)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl)-4-(difluoromethyl)pyridin-2-amine

1927857-56-4

C21H25F2N7O2