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METHACHOLINE CHLORIDE

Product Name
METHACHOLINE CHLORIDE
CAS No.
62-51-1
Chemical Name
METHACHOLINE CHLORIDE
Synonyms
amechol;mecholyl;Methacloline;MECHOLYL CHLORIDE;Mecholine chloride;methylacetylcholine;Methacoline chloride;METHACHOLINE CHLORIDE;methacholiniumchloride;MethacholineChloride>
CBNumber
CB2316248
Molecular Formula
C8H18ClNO2
Formula Weight
195.69
MOL File
62-51-1.mol
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METHACHOLINE CHLORIDE Property

Melting point:
171-173 °C(lit.)
Density 
1.1028 (rough estimate)
refractive index 
1.5790 (estimate)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
powder
color 
White to Almost white
PH
3.0～7.0 (50g/l, 25℃)
Water Solubility 
almost transparency
Merck 
14,5940
BRN 
4162373
Stability:
Unstable - moisture sensitive. Incompatible with oxidizing agents.
LogP
-3.957 (est)
CAS DataBase Reference
62-51-1
EPA Substance Registry System
1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
BR5250000
F 
3-10-21
HS Code 
29239000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2251
Product name
Acetyl-β-methylcholine chloride
Purity
≥98% (TLC), powder
Packaging
25g
Price
$163
Updated
2024/03/01
Sigma-Aldrich
Product number
A2251
Product name
Acetyl-β-methylcholine chloride
Purity
≥98% (TLC), powder
Packaging
100g
Price
$541
Updated
2024/03/01
TCI Chemical
Product number
M0073
Product name
Methacholine Chloride
Purity
>98.0%(T)
Packaging
25g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
M0073
Product name
Methacholine Chloride
Purity
>98.0%(T)
Packaging
500g
Price
$851
Updated
2024/03/01
Cayman Chemical
Product number
23092
Product name
Acetyl-β-methylcholine (chloride)
Purity
≥95%
Packaging
5g
Price
$37
Updated
2024/03/01
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METHACHOLINE CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

colourless to white crystalline powder with a slight

Uses

antihypertensive, antianginal

Uses

Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.

Definition

ChEBI: Methacholine chloride is a quaternary ammonium salt. It contains a methacholine.

General Description

Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.

Biochem/physiol Actions

Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.

Clinical Use

Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.

Purification Methods

It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]

METHACHOLINE CHLORIDE Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Trimethylamine 1-Chloro-2-propanol Diethyl ether Isopropyl alcohol

Preparation Products

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METHACHOLINE CHLORIDE Suppliers

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J & K SCIENTIFIC LTD.
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View Lastest Price from METHACHOLINE CHLORIDE manufacturers

Dideu Industries Group Limited
Product
METHACHOLINE CHLORIDE 62-51-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27

62-51-1, METHACHOLINE CHLORIDERelated Search:

ACETYL-D-CARNITINE CHLORIDE Palmitoyl-L-Carnitine Chloride METHACHOLINE CHLORIDE O-Acetyl-L-carnitine hydrochloride (+/-)-OCTANOYLCARNITINE CHLORIDE BUTYRYL-L-CARNITINE CHLORIDE Choline chloride β-Methylcholine Chloride CHOLINE MYRISTOYL-DL-CARNITINE CHLORIDE PALMITOYL-DL-CARNITINE CHLORIDE BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H] (-)-BICUCULLINE METHOCHLORIDE DL-DECANOYLCARNITINE CHLORIDE DL-LAUROYLCARNITINE CHLORIDE (+/-)-PROPIONYLCARNITINE CHLORIDE ACETYL-DL-CARNITINE HYDROCHLORIDE DL-STEAROYL CARNITINE CHLORIDE

  • beta-methylacetylcholinechloride
  • mecholyl
  • (2-ACETOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE
  • 1-PROPANAMINIUM 2-(ACETYLOXY)-N,N,N-TRIMETHYL CHLORIDE
  • O-ACETYL-BETA-METHYLCHOLINE CHLORIDE
  • TRIMETHYL-B-ACETOXYPROPYLAMMONIUM CHLORIDE
  • TRIMETHYL-BETA-ACETOXYPROPYLAMMONIUM CHLORIDE
  • 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminiuchloride
  • amechol
  • ammonium,(2-hydroxypropyl)trimethyl-,chloride,acetate
  • Mecholine chloride
  • O-Acetyl-β-methylcholine chloride
  • Acetyl-beta-methylcholine chloride,98%
  • Acetyl b-methylcholine chloride 98%+
  • O-Acetyl-beta-methylcholine Chloride Mecholyl Chloride
  • 2-acetoxy-N,N,N-triMethylpropan-1-aMiniuM chloride
  • Methacholine Chloride (AS)
  • Methacholine Chloride (500 mg) (AS)
  • 2-acetyloxypropyl(trimethyl)ammonium chloride
  • methacholiniumchloride
  • methylacetylcholine
  • Acetyl-β-methylcholine chloride
  • ACETYL-B-METHYLCHOLINE CHLORIDECRYSTALLI NE
  • METHACHOLINE CHLORIDE ACETYL-B-METHYLCHO LIN
  • METHACHOLINE CHLORIDE 98+%
  • METHACHOLINE CHLORIDE CRYSTALLINE
  • Methacloline
  • METHACHOLINECHLORIDE,CRYSTAL
  • METHACHOLINECHLORIDE,CRYSTAL,USP
  • METHACHOLINECHLORIDE,HIGHPURITY
  • Methacoline chloride
  • (2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride
  • ACETYL-2-METHYLCHOLINE CHLORIDE
  • ACETYL-BETA-METHYLCHOLINE CHLORIDE
  • ACETYL-B-METHYLCHOLINE CHLORIDE
  • METHACHOLINE CHLORIDE
  • MECHOLYL CHLORIDE
  • (2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE ACETATE
  • 2-(ACETYLOXY)-N,N,N-TRIMETHYL-1-PROPANAMINIUM CHLORIDE
  • MethacholineChloride&gt
  • Acetyl-β-methylcholine chloride
  • METHACHOLINE CHLORIDE USP/EP/BP
  • Methacholine Chloride (AS) (1396364)
  • O-Acetyl-β-methylcholine Chloride
  • 62-51-1
  • C8H18NO2Cl
  • C8H18ClNO2
  • CH3COOCHCH3CH2NClCH33
  • Ammonium Chlorides (Quaternary)
  • Quaternary Ammonium Compounds
  • LOPRESSOR
  • inhibitor
  • Ammonium Chlorides (Quaternary)
  • Quaternary Ammonium Compounds