METHACHOLINE CHLORIDE
- Product Name
- METHACHOLINE CHLORIDE
- CAS No.
- 62-51-1
- Chemical Name
- METHACHOLINE CHLORIDE
- Synonyms
- amechol;mecholyl;Methacloline;MECHOLYL CHLORIDE;Mecholine chloride;methylacetylcholine;Methacoline chloride;METHACHOLINE CHLORIDE;methacholiniumchloride;MethacholineChloride>
- CBNumber
- CB2316248
- Molecular Formula
- C8H18ClNO2
- Formula Weight
- 195.69
- MOL File
- 62-51-1.mol
METHACHOLINE CHLORIDE Property
- Melting point:
- 171-173 °C(lit.)
- Density
- 1.1028 (rough estimate)
- refractive index
- 1.5790 (estimate)
- storage temp.
- -20°C
- solubility
- H2O: 50 mg/mL, clear, colorless
- form
- powder
- color
- White to Almost white
- PH
- 3.0～7.0 (50g/l, 25℃)
- Water Solubility
- almost transparency
- Merck
- 14,5940
- BRN
- 4162373
- Stability:
- Unstable - moisture sensitive. Incompatible with oxidizing agents.
- LogP
- -3.957 (est)
- CAS DataBase Reference
- 62-51-1
- EPA Substance Registry System
- 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- BR5250000
- F
- 3-10-21
- HS Code
- 29239000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2251
- Product name
- Acetyl-β-methylcholine chloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 25g
- Price
- $163
- Updated
- 2024/03/01
- Product number
- A2251
- Product name
- Acetyl-β-methylcholine chloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 100g
- Price
- $541
- Updated
- 2024/03/01
- Product number
- M0073
- Product name
- Methacholine Chloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $89
- Updated
- 2024/03/01
- Product number
- M0073
- Product name
- Methacholine Chloride
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $851
- Updated
- 2024/03/01
- Product number
- 23092
- Product name
- Acetyl-β-methylcholine (chloride)
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $37
- Updated
- 2024/03/01
METHACHOLINE CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
colourless to white crystalline powder with a slight
Uses
antihypertensive, antianginal
Uses
Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.
Definition
ChEBI: Methacholine chloride is a quaternary ammonium salt. It contains a methacholine.
General Description
Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.
Biochem/physiol Actions
Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.
Clinical Use
Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.
Purification Methods
It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]
METHACHOLINE CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
METHACHOLINE CHLORIDE Suppliers
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- --
- Fax
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- Country
- United Kingdom
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- 4521
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View Lastest Price from METHACHOLINE CHLORIDE manufacturers
- Product
- METHACHOLINE CHLORIDE 62-51-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-27