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Troxerutin

Product Name
Troxerutin
CAS No.
7085-55-4
Chemical Name
Troxerutin
Synonyms
Troxerutine;Venoruton;Troxerutin CRS;RUVEN;Z-6000;Qucrutin;Rufen P-4;VASTRIBIL;POSORUTIN;Troxrutin
CBNumber
CB2317568
Molecular Formula
C33H42O19
Formula Weight
742.68
MOL File
7085-55-4.mol
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Troxerutin Property

Melting point:
181°C
Boiling point:
1058.4±65.0 °C(Predicted)
Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
pka
5.92±0.40(Predicted)
color 
Light Yellow to Yellow
Merck 
14,9789
BRN 
4778232
InChI
InChI=1/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/s3
InChIKey
KMPBUGGPUQOWMJ-NXPSPVSKSA-N
SMILES
O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O1)O)C1C(C2=C(C=C(OCCO)C=C2OC=1C1C=CC(OCCO)=C(OCCO)C=1)O)=O |&1:1,2,3,5,7,10,12,14,16,18,r|
CAS DataBase Reference
7085-55-4(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
LK8331500
HS Code 
2938100000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000497
Product name
Troxerutin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000497
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2815
Product name
Troxerutin
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$365
Updated
2024/03/01
TCI Chemical
Product number
T3541
Product name
Troxerutin
Purity
>90.0%(HPLC)
Packaging
5g
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
T3541
Product name
Troxerutin
Purity
>90.0%(HPLC)
Packaging
25g
Price
$154
Updated
2024/03/01
Cayman Chemical
Product number
27220
Product name
Troxerutin
Packaging
10g
Price
$55
Updated
2024/03/01
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Troxerutin Chemical Properties,Usage,Production

Chemical Properties

Yellow Powder

Originator

Venoruton,Novartis Co

Uses

Used in the treatment of venous disorders

Uses

vasoprotectant

Uses

Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.

Manufacturing Process

In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland

Therapeutic Function

Topical venotonic

target

VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt

Troxerutin Preparation Products And Raw materials

Raw materials

Preparation Products

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Troxerutin Suppliers

Wuhan Beileye Biomedical Technology Co., Ltd.
Tel
18086118078
Email
2696158611@qq.com
Country
China
ProdList
4280
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2895
Advantage
58
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View Lastest Price from Troxerutin manufacturers

Liaoning Pharmaceutical Innovation Co., Ltd
Product
Troxerutin 7085-55-4
Price
US $100.00-50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20000tons
Release date
2024-03-07
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Troxerutin 7085-55-4
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-21
Wuhan Boyuan Import & Export Co., LTD
Product
Troxerutin 7085-55-4
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000ton
Release date
2023-12-18

7085-55-4, TroxerutinRelated Search:


  • 3μ,4μ,7-Tris[O-(2-hydroxyethyl)]rutin, Troxerutin
  • Troxerutin,Trihydroxyethylrutin
  • 3',4',7-Tris(hydroxyethyl)rutin
  • 3,5-Dihydroxy-3',4',7-tris(2-hydroxyethoxy)flavone 3-rutinoside
  • Factor-P-zyma
  • 2-[3,4-BIS(2-HYDROXYETHOXY)PHENYL]-3-[[6-O-(6-O-DEOXY-A-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-5-HYDROXY-7-(2-HYDROXYETHOXY)-4H-1-BENZOPYRAN-4-ONE
  • Trihydroxylrutin
  • Trihydroxyethylrutoside
  • Trioxyethylrutin
  • 2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-a-L-mannopyranosyl)-B-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one, Posorutin, Ruven, Vastribil,
  • 4H-1-Benzopyran-4-one, 2-3,4-bis(2-hydroxyethoxy)phenyl-3-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-5-hydroxy-7-(2-hydroxyethoxy)-
  • Venoruton
  • Troxerutine
  • VITAMIN P4 (TROXERUTIN)
  • 7,3’,4’-tris[O-(2-hydroxyethyl)]rutin
  • 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-o
  • Tris-O-(2-hydroxyethyl)rutin
  • Trihydroxyethylrutin, CP
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  • Rufen P-4
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  • Trihydroxyethylrutin, 3',4',7-Tris[O-(2-hydroxyethyl)]rutin
  • 4H-1-Benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-
  • Hydroxyetbylrutin
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