Troxerutin

Product Name: Troxerutin
CAS No.: 7085-55-4
Chemical Name: Troxerutin
Synonyms: Troxerutine;Venoruton;Troxerutin CRS;RUVEN;95%UV;Z-6000;95% UV;Qucrutin;Rufen P-4;VASTRIBIL
CBNumber: CB2317568
Molecular Formula: C33H42O19
Formula Weight: 742.68
MOL File: 7085-55-4.mol

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Troxerutin Property

Melting point:: 181°C
Boiling point:: 1058.4±65.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
form: Solid
pka: 5.92±0.40(Predicted)
color: Light Yellow to Yellow
Merck: 14,9789
BRN: 4778232
InChI: InChI=1/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/s3
InChIKey: KMPBUGGPUQOWMJ-NXPSPVSKSA-N
SMILES: O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O1)O)C1C(C2=C(C=C(OCCO)C=C2OC=1C1C=CC(OCCO)=C(OCCO)C=1)O)=O |&1:1,2,3,5,7,10,12,14,16,18,r|
CAS DataBase Reference: 7085-55-4(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: LK8331500
HS Code: 2938100000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000497
Product name: Troxerutin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 20 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3724
Product name: Troxerutin
Purity: ≥97% (HPLC)
Packaging: 50 mg
Price: $81.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2815
Product name: Troxerutin
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $375
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000497
Product name: Troxerutin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000497
Price: $220
Updated: 2024/03/01

TCI Chemical

Product number: T3541
Product name: Troxerutin
Purity: >90.0%(HPLC)
Packaging: 5g
Price: $55
Updated: 2025/07/31

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Troxerutin Chemical Properties,Usage,Production

Chemical Properties

Yellow Powder

Originator

Venoruton,Novartis Co

Uses

vasoprotectant

Uses

Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.

Uses

Used in the treatment of venous disorders

Manufacturing Process

In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland

Therapeutic Function

Topical venotonic

Biological Activity

Troxerutin is a brain penetrant, vasoprotective flavonol isolated from Sophora japonica, which is present in many other plants including grains, fruits, and vegetables. Troxerutin exhibits multiple biological activities including anti-oxidative, anti-radiation, and anti-inflammatory. Recent study indicates th at troxerutin improves the synaptic failure induced by Aβ peptide. It appears th at Troxerutin could promote radioprotection by stimulating NEAT1 to upregulate PDPK1 expression by suppressing miR-147.

target

VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt

References

[1] Patent: CN104478972, 2017, B. Location in patent: Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0031
[2] Patent: CN106892950, 2017, A. Location in patent: Paragraph 0018-0026
[3] Chinese Chemical Letters, 2013, vol. 24, # 3, p. 223 - 226
[4] Patent: CN103601772, 2016, B. Location in patent: Paragraph 0011-0014
[5] Patent: CN104447914, 2017, B. Location in patent: Paragraph 0013; 0014

Troxerutin Preparation Products And Raw materials

Raw materials

2-Chloroethanol

Preparation Products

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Troxerutin Suppliers

Canada 2 CHINA 447 Europe 3 France 2 Germany 2 India 9 Japan 1 Switzerland 1 United Kingdom 10 United States 32 Global 509

NANJING DORRA PHARMACEUTICAL TECHNOLOGY CO.,LTD.

Tel: 025-82232968 15250951870
Email: sales@dorrapharma.com
Country: China
ProdList: 20
Advantage: 58

Wuhan Beileye Biomedical Technology Co., Ltd.

Tel: 18086118078
Email: 2696158611@qq.com
Country: China
ProdList: 4277
Advantage: 58

XI'AN RONGBAI BIOTECHNOLOGY CO., LTD.

Tel: 029-029-81629930 13227736008
Email: rb@xarbkj.com
Country: China
ProdList: 349
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

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View Lastest Price from Troxerutin manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Troxerutin 7085-55-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Troxerutin 7085-55-4
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min; EP
Supply Ability: 500KG
Release date: 2021-06-02

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Troxerutin 7085-55-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-14

7085-55-4, TroxerutinRelated Search:

Hydroxyethyl Cellulose Tricine 2-Hydroxyethanesulphonic acid Methyl 2-hydroxyethyl cellulose Hydroxyethyl starch BIS-Tris 2-(METHYLSULFONYL)ETHANOL 2-(2-Aminoethylamino)ethanol Sodium isethionate BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE) Thiamine hydrochloride VITAMIN CK3 Retinyl acetate Vitamin K1 Nicotinic acid Tris(hydroxymethyl)aminomethane Vitamin D3 LITHIUM CITRATE TETRAHYDRATE

3μ,4μ,7-Tris[O-(2-hydroxyethyl)]rutin, Troxerutin

Troxerutin，Trihydroxyethylrutin

3',4',7-Tris(hydroxyethyl)rutin

3,5-Dihydroxy-3',4',7-tris(2-hydroxyethoxy)flavone 3-rutinoside

Factor-P-zyma

2-[3,4-BIS(2-HYDROXYETHOXY)PHENYL]-3-[[6-O-(6-O-DEOXY-A-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-5-HYDROXY-7-(2-HYDROXYETHOXY)-4H-1-BENZOPYRAN-4-ONE

Trihydroxylrutin

Trihydroxyethylrutoside

Trioxyethylrutin

2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-a-L-mannopyranosyl)-B-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one, Posorutin, Ruven, Vastribil,

4H-1-Benzopyran-4-one, 2-3,4-bis(2-hydroxyethoxy)phenyl-3-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-5-hydroxy-7-(2-hydroxyethoxy)-

Venoruton

Troxerutine

VITAMIN P4 (TROXERUTIN)

7,3’,4’-tris[O-(2-hydroxyethyl)]rutin

2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-o

Tris-O-(2-hydroxyethyl)rutin

Trihydroxyethylrutin, CP

Tris(hydroxyethyl)rutin

Tris(hydroxyethyl)rutoside

Rufen P-4

Venoruton P-4

Z-6000

TROXERUTIN(P)

2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-α-L-Mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one

Trihydroxyethylrutin, 3',4',7-Tris[O-(2-hydroxyethyl)]rutin

4H-1-Benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-

Hydroxyetbylrutin

TROXERUTIN

TRIHYDROXYETHYLRUTIN

VASTRIBIL

RUVEN

POSORUTIN

3',4',7-TRIS-O-(2-HYDROXYETHYL)RUTIN

Troxerutin CRS

Troxerutin (85%)

2-(3,4-Bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

Troxerutin USP/EP/BP

Natural Sophora Japonica Extract 98% CAS?7085-55-4?Troxerutin

Natural Herbal Extract Troxerutin (CAS 7085-55-4)

Qucrutin

TroxerutinQ: What is Troxerutin Q: What is the CAS Number of Troxerutin Q: What is the storage condition of Troxerutin Q: What are the applications of Troxerutin

QuKe rutin

Trihydroxyethylrutin Troxerutin-P OT15980 OT-15980

Troxrutin

95% UV

95%UV

Qu Ke Lu Ding

4H-1-Benzopyran-4-one,2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-

Tris-O-(2-hydroxyethyl)rutin-RM

Troxerutin(Oral/Injection)

Troxerutin, 10 mM in DMSO

7085-55-4

C33H42O19

Natural Dyes

BioChemical

Biochemicals and Reagents

Intermediates & Fine Chemicals