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Troxerutin

Product Name
Troxerutin
CAS No.
7085-55-4
Chemical Name
Troxerutin
Synonyms
Troxerutine;Venoruton;Troxerutin CRS;RUVEN;95%UV;Z-6000;95% UV;Qucrutin;Rufen P-4;VASTRIBIL
CBNumber
CB2317568
Molecular Formula
C33H42O19
Formula Weight
742.68
MOL File
7085-55-4.mol
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Troxerutin Property

Melting point:
181°C
Boiling point:
1058.4±65.0 °C(Predicted)
Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
form 
Solid
pka
5.92±0.40(Predicted)
color 
Light Yellow to Yellow
Merck 
14,9789
BRN 
4778232
InChI
InChI=1/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/s3
InChIKey
KMPBUGGPUQOWMJ-NXPSPVSKSA-N
SMILES
O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O1)O)C1C(C2=C(C=C(OCCO)C=C2OC=1C1C=CC(OCCO)=C(OCCO)C=1)O)=O |&1:1,2,3,5,7,10,12,14,16,18,r|
CAS DataBase Reference
7085-55-4(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
LK8331500
HS Code 
2938100000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000497
Product name
Troxerutin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000497
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2815
Product name
Troxerutin
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$365
Updated
2024/03/01
TCI Chemical
Product number
T3541
Product name
Troxerutin
Purity
>90.0%(HPLC)
Packaging
5g
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
T3541
Product name
Troxerutin
Purity
>90.0%(HPLC)
Packaging
25g
Price
$154
Updated
2024/03/01
Cayman Chemical
Product number
27220
Product name
Troxerutin
Packaging
10g
Price
$55
Updated
2024/03/01
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Troxerutin Chemical Properties,Usage,Production

Chemical Properties

Yellow Powder

Originator

Venoruton,Novartis Co

Uses

Used in the treatment of venous disorders

Uses

vasoprotectant

Uses

Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.

Manufacturing Process

In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland

Therapeutic Function

Topical venotonic

Biological Activity

Troxerutin is a brain penetrant, vasoprotective flavonol isolated from Sophora japonica, which is present in many other plants including grains, fruits, and vegetables. Troxerutin exhibits multiple biological activities including anti-oxidative, anti-radiation, and anti-inflammatory. Recent study indicates th at troxerutin improves the synaptic failure induced by Aβ peptide. It appears th at Troxerutin could promote radioprotection by stimulating NEAT1 to upregulate PDPK1 expression by suppressing miR-147.

target

VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt

Troxerutin Preparation Products And Raw materials

Raw materials

2-Chloroethanol

Preparation Products

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View Lastest Price from Troxerutin manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Troxerutin 7085-55-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Troxerutin 7085-55-4
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min; EP
Supply Ability
500KG
Release date
2021-06-02
Hebei Lingding Biotechnology Co., Ltd.
Product
Troxerutin 7085-55-4
Price
US $100.00/KG
Min. Order
0.5KG
Purity
99%
Supply Ability
1 T
Release date
2025-01-20

7085-55-4, TroxerutinRelated Search:

Hydroxyethyl Cellulose Tricine 2-Hydroxyethanesulphonic acid Methyl 2-hydroxyethyl cellulose Hydroxyethyl starch BIS-Tris 2-(METHYLSULFONYL)ETHANOL 2-(2-Aminoethylamino)ethanol Sodium isethionate BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE) Tris(hydroxymethyl)aminomethane Vitamin D3 Retinyl acetate Vitamin K1 Nicotinic acid VITAMIN CK3 Thiamine hydrochloride LITHIUM CITRATE TETRAHYDRATE

  • 3μ,4μ,7-Tris[O-(2-hydroxyethyl)]rutin, Troxerutin
  • Troxerutin，Trihydroxyethylrutin
  • 3',4',7-Tris(hydroxyethyl)rutin
  • 3,5-Dihydroxy-3',4',7-tris(2-hydroxyethoxy)flavone 3-rutinoside
  • Factor-P-zyma
  • 2-[3,4-BIS(2-HYDROXYETHOXY)PHENYL]-3-[[6-O-(6-O-DEOXY-A-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-5-HYDROXY-7-(2-HYDROXYETHOXY)-4H-1-BENZOPYRAN-4-ONE
  • Trihydroxylrutin
  • Trihydroxyethylrutoside
  • Trioxyethylrutin
  • 2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-a-L-mannopyranosyl)-B-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one, Posorutin, Ruven, Vastribil,
  • 4H-1-Benzopyran-4-one, 2-3,4-bis(2-hydroxyethoxy)phenyl-3-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-5-hydroxy-7-(2-hydroxyethoxy)-
  • Venoruton
  • Troxerutine
  • VITAMIN P4 (TROXERUTIN)
  • 7,3’,4’-tris[O-(2-hydroxyethyl)]rutin
  • 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-o
  • Tris-O-(2-hydroxyethyl)rutin
  • Trihydroxyethylrutin, CP
  • Tris(hydroxyethyl)rutin
  • Tris(hydroxyethyl)rutoside
  • Rufen P-4
  • Venoruton P-4
  • Z-6000
  • TROXERUTIN(P)
  • 2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-α-L-Mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one
  • Trihydroxyethylrutin, 3',4',7-Tris[O-(2-hydroxyethyl)]rutin
  • 4H-1-Benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-
  • Hydroxyetbylrutin
  • TROXERUTIN
  • TRIHYDROXYETHYLRUTIN
  • VASTRIBIL
  • RUVEN
  • POSORUTIN
  • 3',4',7-TRIS-O-(2-HYDROXYETHYL)RUTIN
  • Troxerutin CRS
  • Troxerutin (85%)
  • 2-(3,4-Bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
  • Troxerutin USP/EP/BP
  • Natural Sophora Japonica Extract 98% CAS?7085-55-4?Troxerutin
  • Natural Herbal Extract Troxerutin (CAS 7085-55-4)
  • Qucrutin
  • TroxerutinQ: What is Troxerutin Q: What is the CAS Number of Troxerutin Q: What is the storage condition of Troxerutin Q: What are the applications of Troxerutin
  • QuKe rutin
  • Trihydroxyethylrutin Troxerutin-P OT15980 OT-15980
  • Troxrutin
  • 95% UV
  • 95%UV
  • Qu Ke Lu Ding
  • 4H-1-Benzopyran-4-one,2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-
  • Tris-O-(2-hydroxyethyl)rutin-RM
  • Troxerutin(Oral/Injection)
  • Troxerutin, 10 mM in DMSO
  • 7085-55-4
  • C33H42O19
  • Natural Dyes
  • BioChemical
  • Biochemicals and Reagents
  • Intermediates & Fine Chemicals